A clonal CD4-positive T-cell line established from the blood of a patient with Sézary syndrome

J. Todd Abrams, Stuart Lessin, Subrata K. Ghosh, William Ju, Eric C. Vonderheid, Peter Nowell, George Murphy, Bruce Elfenbein, Elaine Defreitas

Research output: Contribution to journalArticle

Abstract

The reported inability to establish long-term T-cell lines from the blood of cutaneous T-cell lymphoma patients with circulating neoplastic T cells has hindered the development of an in vitro system to investigate Sézary syndrome. We have established a rapidly proliferating T-cell line from the peripheral blood of a patient with Sezary syndrome, which expresses a mature helper T-cell phenotype and contains cytogenetic abnormalities and T-cell receptor gene rearrangements identical to those in the patient's blood. The method of establishment and characteristics of this line are described.

Original languageEnglish (US)
Pages (from-to)31-37
Number of pages7
JournalJournal of Investigative Dermatology
Volume96
Issue number1
StatePublished - Jan 1991
Externally publishedYes

ASJC Scopus subject areas

  • Dermatology

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