A clonal CD4-positive T-cell line established from the blood of a patient with Sézary syndrome

J. Todd Abrams, Stuart Lessin, Subrata K. Ghosh, William Ju, Eric C. Vonderheid, Peter Nowell, George Murphy, Bruce Elfenbein, Elaine Defreitas

Research output: Contribution to journalArticle

Abstract

The reported inability to establish long-term T-cell lines from the blood of cutaneous T-cell lymphoma patients with circulating neoplastic T cells has hindered the development of an in vitro system to investigate Sézary syndrome. We have established a rapidly proliferating T-cell line from the peripheral blood of a patient with Sezary syndrome, which expresses a mature helper T-cell phenotype and contains cytogenetic abnormalities and T-cell receptor gene rearrangements identical to those in the patient's blood. The method of establishment and characteristics of this line are described.

Original languageEnglish (US)
Pages (from-to)31-37
Number of pages7
JournalJournal of Investigative Dermatology
Volume96
Issue number1
StatePublished - Jan 1991
Externally publishedYes

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T-cells
Blood
T-Lymphocytes
Cell Line
T-Lymphocyte Gene Rearrangement
Sezary Syndrome
Circulating Neoplastic Cells
T-Cell Receptor Genes
Cutaneous T-Cell Lymphoma
Helper-Inducer T-Lymphocytes
Chromosome Aberrations
Phenotype
T-Cell Antigen Receptor
Genes

ASJC Scopus subject areas

  • Dermatology

Cite this

Todd Abrams, J., Lessin, S., Ghosh, S. K., Ju, W., Vonderheid, E. C., Nowell, P., ... Defreitas, E. (1991). A clonal CD4-positive T-cell line established from the blood of a patient with Sézary syndrome. Journal of Investigative Dermatology, 96(1), 31-37.

A clonal CD4-positive T-cell line established from the blood of a patient with Sézary syndrome. / Todd Abrams, J.; Lessin, Stuart; Ghosh, Subrata K.; Ju, William; Vonderheid, Eric C.; Nowell, Peter; Murphy, George; Elfenbein, Bruce; Defreitas, Elaine.

In: Journal of Investigative Dermatology, Vol. 96, No. 1, 01.1991, p. 31-37.

Research output: Contribution to journalArticle

Todd Abrams, J, Lessin, S, Ghosh, SK, Ju, W, Vonderheid, EC, Nowell, P, Murphy, G, Elfenbein, B & Defreitas, E 1991, 'A clonal CD4-positive T-cell line established from the blood of a patient with Sézary syndrome', Journal of Investigative Dermatology, vol. 96, no. 1, pp. 31-37.
Todd Abrams J, Lessin S, Ghosh SK, Ju W, Vonderheid EC, Nowell P et al. A clonal CD4-positive T-cell line established from the blood of a patient with Sézary syndrome. Journal of Investigative Dermatology. 1991 Jan;96(1):31-37.
Todd Abrams, J. ; Lessin, Stuart ; Ghosh, Subrata K. ; Ju, William ; Vonderheid, Eric C. ; Nowell, Peter ; Murphy, George ; Elfenbein, Bruce ; Defreitas, Elaine. / A clonal CD4-positive T-cell line established from the blood of a patient with Sézary syndrome. In: Journal of Investigative Dermatology. 1991 ; Vol. 96, No. 1. pp. 31-37.
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