A clinical picture of Guillain-Barré Syndrome in children in the United States

Caitlin W. Hicks, Benjamin Kay, Sarah E. Worley, Manikum Moodley

Research output: Contribution to journalArticlepeer-review

Abstract

The authors describe the demographics, clinical presentation, investigation, treatment, and outcomes of pediatric patients with Guillain-Barré syndrome. They identified 35 pediatric patients with Guillain-Barré syndrome presenting to a tertiary academic center over a 20-year period. The most common presenting symptoms were paresthesias (54%), weakness (49%), and myalgias (49%). Sensation was affected in 54% of patients, and hyporeflexia or areflexia was present in 94% of patients. Cranial nerve dysfunction (46%) and autonomic involvement (eg, changes in blood pressure, pulse, bowel/bladder control, or priapism; 46%) were also common. Autonomic dysfunction, cranial nerve involvement, and albuminocytological dissociation were significantly associated with a decreased time to nadir, the point when symptoms peaked (P =.015,.007, and.005, respectively). Although not statistically significant, treatment with plasmapheresis had a better success rate than intravenous immunoglobulin. The authors' results will help to further delineate the clinical picture of Guillain-Barré syndrome in children and refine treatment strategies.

Original languageEnglish (US)
Pages (from-to)1504-1510
Number of pages7
JournalJournal of child neurology
Volume25
Issue number12
DOIs
StatePublished - Dec 2010
Externally publishedYes

Keywords

  • Guillain-Barré syndrome
  • demyelinating disease
  • pediatrics

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

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