A clinical drug library screen identifies astemizole as an antimalarial agent

Curtis R. Chong, Xiaochun Chen, Lirong Shi, Jun O. Liu, David J. Sullivan

Research output: Contribution to journalArticle

Abstract

The high cost and protracted time line of new drug discovery are major roadblocks to creating therapies for neglected diseases. To accelerate drug discovery we created a library of 2,687 existing drugs and screened for inhibitors of the human malaria parasite Plasmodium falciparum. The antihistamine astemizole and its principal human metabolite are promising new inhibitors of chloroquine-sensitive and multidrug-resistant parasites, and they show efficacy in two mouse models of malaria.

Original languageEnglish (US)
Pages (from-to)415-416
Number of pages2
JournalNature chemical biology
Volume2
Issue number8
DOIs
StatePublished - Aug 2006

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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