@article{c9e35b3c4cfd4e3c9c809d6c70be1341,
title = "A clinical drug library screen identifies astemizole as an antimalarial agent",
abstract = "The high cost and protracted time line of new drug discovery are major roadblocks to creating therapies for neglected diseases. To accelerate drug discovery we created a library of 2,687 existing drugs and screened for inhibitors of the human malaria parasite Plasmodium falciparum. The antihistamine astemizole and its principal human metabolite are promising new inhibitors of chloroquine-sensitive and multidrug-resistant parasites, and they show efficacy in two mouse models of malaria.",
author = "Chong, {Curtis R.} and Xiaochun Chen and Lirong Shi and Liu, {Jun O.} and Sullivan, {David J.}",
note = "Funding Information: The authors thank T. Shapiro and S. Prigge for manuscript comments and P. Okinedo for advice and encouragement. This work was supported by The Johns Hopkins Malaria Research Institute, Fund for Medical Discovery and Department of Pharmacology and The Keck Foundation. D.J.S. is supported by National Institutes of Health RO1 A145774 and a Pew Scholars Award in Biomedical Sciences. C.R.C. is supported by the Congressionally Directed Breast Cancer Research Program Predoctoral Fellowship and by the National Institutes of Health Medical Scientist Training Program. The culturing of P. falciparum was supported by National Center for Research Resources grant GPDGCRC RR0052.",
year = "2006",
month = aug,
doi = "10.1038/nchembio806",
language = "English (US)",
volume = "2",
pages = "415--416",
journal = "Nature chemical biology",
issn = "1552-4450",
publisher = "Nature Publishing Group",
number = "8",
}