A clinical drug library screen identifies astemizole as an antimalarial agent

Curtis R. Chong, Xiaochun Chen, Lirong Shi, Jun Liu, David J Sullivan

Research output: Contribution to journalArticle

Abstract

The high cost and protracted time line of new drug discovery are major roadblocks to creating therapies for neglected diseases. To accelerate drug discovery we created a library of 2,687 existing drugs and screened for inhibitors of the human malaria parasite Plasmodium falciparum. The antihistamine astemizole and its principal human metabolite are promising new inhibitors of chloroquine-sensitive and multidrug-resistant parasites, and they show efficacy in two mouse models of malaria.

Original languageEnglish (US)
Pages (from-to)415-416
Number of pages2
JournalNature Chemical Biology
Volume2
Issue number8
DOIs
StatePublished - Aug 2006

Fingerprint

Astemizole
Antimalarials
Drug Discovery
Parasites
Neglected Diseases
Falciparum Malaria
Histamine Antagonists
Chloroquine
Pharmaceutical Preparations
Malaria
Costs and Cost Analysis
Therapeutics

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

A clinical drug library screen identifies astemizole as an antimalarial agent. / Chong, Curtis R.; Chen, Xiaochun; Shi, Lirong; Liu, Jun; Sullivan, David J.

In: Nature Chemical Biology, Vol. 2, No. 8, 08.2006, p. 415-416.

Research output: Contribution to journalArticle

Chong, Curtis R. ; Chen, Xiaochun ; Shi, Lirong ; Liu, Jun ; Sullivan, David J. / A clinical drug library screen identifies astemizole as an antimalarial agent. In: Nature Chemical Biology. 2006 ; Vol. 2, No. 8. pp. 415-416.
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