A chronically implanted system for automatic defibrillation in active conscious dogs. Experimental model for treatment of sudden death from ventricular fibrillation

M. Mirowski, Morton Maimon Mower, A. Langer, M. S. Heilman, J. Schreibman

Research output: Contribution to journalArticle

Abstract

Ventricular defibrillation was achieved in active conscious dogs with a chronically implanted automatic system composed of a defibrillator and an alternating current fibrillator. The hermetically sealed defibrillator is encased in titanium, weighs 250 g and has a volume of 145 ml. The sensor continuously monitors ventricular electrical activity and recognizes fibrillation by the absence of isoelectric potential segments. Fibrillation is induced by placing a magnet over the implanted fibrillator. The resulting syncope closely resembles the clinical entity of sudden death, while the defibrillator automatically restores normal rhythm with a truncated exponential pulse of 30 J, 15 seconds after the onset of the arrhythmia. The operational status of the defibrillator can be tested in vitro and noninvasively in vivo with an external analyzer. This experimental model allows for the first time a long-term study of the automatic implantable defibrillator approach to prevent sudden death from ventricular fibrillation under a variety of physiopathologic conditions.

Original languageEnglish (US)
Pages (from-to)90-94
Number of pages5
JournalCirculation
Volume58
Issue number1
StatePublished - 1978

Fingerprint

Defibrillators
Ventricular Fibrillation
Sudden Death
Theoretical Models
Dogs
Magnets
Implantable Defibrillators
Syncope
Titanium
Cardiac Arrhythmias

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

A chronically implanted system for automatic defibrillation in active conscious dogs. Experimental model for treatment of sudden death from ventricular fibrillation. / Mirowski, M.; Mower, Morton Maimon; Langer, A.; Heilman, M. S.; Schreibman, J.

In: Circulation, Vol. 58, No. 1, 1978, p. 90-94.

Research output: Contribution to journalArticle

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