TY - JOUR
T1 - A Cholinergic Mechanism for Reward Timing within Primary Visual Cortex
AU - Chubykin, Alexander A.
AU - Roach, Emma B.
AU - Bear, Mark F.
AU - Shuler, Marshall G.Hussain
N1 - Funding Information:
We thank Harel Shouval, Jeff Gavornik, and Arnold Heynen for insightful comments and critiques. We are grateful to Jill McGaughy, Weidong Hu, and Peter Holland for sharing their histological expertise. We thank Tanya Marton, Vijay M.K. Namboodiri, and Camila Zold for helpful discussions of the experimental design. We also thank Hannah Joo and Shelby Hecht for their assistance with data collection, electrode drive assembly, and histology and Kathleen Oram, Erik Sklar, and Suzanne Meagher for technical and administrative support. This work was funded by NIMH (R01 MH084911) and start-up funds provided by the Johns Hopkins University to M.G.H.S, NIDA (F31 DA026687) to E.B.R., and grants from NEI (R01 EYO12309) and NICHD (R01 HD046943) to M.F.B.
PY - 2013/2/20
Y1 - 2013/2/20
N2 - Neurons in rodent primary visual cortex (V1) relate operantly conditioned stimulus-reward intervals with modulated patterns of spiking output, but little is known about the locus or mechanism of this plasticity. Here we show that cholinergic basal forebrain projections to V1 are necessary for the neural acquisition, but not the expression, of reward timing in the visual cortex of awake, behaving animals. We then mimic reward timing in vitro by pairing white matter stimulation with muscarinic receptor activation at a fixed interval and show that this protocol results in the prolongation of electrically evoked spike train durations out to the conditioned interval. Together, these data suggest that V1 possesses the circuitry and plasticity to support reward time prediction learning and the cholinergic system serves as an important reinforcement signal which, in vivo, conveys to the cortex the outcome of behavior
AB - Neurons in rodent primary visual cortex (V1) relate operantly conditioned stimulus-reward intervals with modulated patterns of spiking output, but little is known about the locus or mechanism of this plasticity. Here we show that cholinergic basal forebrain projections to V1 are necessary for the neural acquisition, but not the expression, of reward timing in the visual cortex of awake, behaving animals. We then mimic reward timing in vitro by pairing white matter stimulation with muscarinic receptor activation at a fixed interval and show that this protocol results in the prolongation of electrically evoked spike train durations out to the conditioned interval. Together, these data suggest that V1 possesses the circuitry and plasticity to support reward time prediction learning and the cholinergic system serves as an important reinforcement signal which, in vivo, conveys to the cortex the outcome of behavior
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U2 - 10.1016/j.neuron.2012.12.039
DO - 10.1016/j.neuron.2012.12.039
M3 - Article
C2 - 23439124
AN - SCOPUS:84874226821
SN - 0896-6273
VL - 77
SP - 723
EP - 735
JO - Neuron
JF - Neuron
IS - 4
ER -