A Cholinergic Mechanism for Reward Timing within Primary Visual Cortex

Alexander A. Chubykin, Emma B. Roach, Mark F. Bear, Marshall Shuler

Research output: Contribution to journalArticle

Abstract

Neurons in rodent primary visual cortex (V1) relate operantly conditioned stimulus-reward intervals with modulated patterns of spiking output, but little is known about the locus or mechanism of this plasticity. Here we show that cholinergic basal forebrain projections to V1 are necessary for the neural acquisition, but not the expression, of reward timing in the visual cortex of awake, behaving animals. We then mimic reward timing in vitro by pairing white matter stimulation with muscarinic receptor activation at a fixed interval and show that this protocol results in the prolongation of electrically evoked spike train durations out to the conditioned interval. Together, these data suggest that V1 possesses the circuitry and plasticity to support reward time prediction learning and the cholinergic system serves as an important reinforcement signal which, in vivo, conveys to the cortex the outcome of behavior

Original languageEnglish (US)
Pages (from-to)723-735
Number of pages13
JournalNeuron
Volume77
Issue number4
DOIs
StatePublished - Feb 20 2013

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Visual Cortex
Reward
Cholinergic Agents
Muscarinic Receptors
Rodentia
Learning
Neurons

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

A Cholinergic Mechanism for Reward Timing within Primary Visual Cortex. / Chubykin, Alexander A.; Roach, Emma B.; Bear, Mark F.; Shuler, Marshall.

In: Neuron, Vol. 77, No. 4, 20.02.2013, p. 723-735.

Research output: Contribution to journalArticle

Chubykin, Alexander A. ; Roach, Emma B. ; Bear, Mark F. ; Shuler, Marshall. / A Cholinergic Mechanism for Reward Timing within Primary Visual Cortex. In: Neuron. 2013 ; Vol. 77, No. 4. pp. 723-735.
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