A chemiluminescent probe specific for singlet oxygen

Gary H. Posner, John R. Lever, Kyo Miura, Carol Lisek, Howard H. Seliger, Ambler Thompson

Research output: Contribution to journalArticlepeer-review

Abstract

We have synthesized a methoxyvinylpyrene (MVP) in order to model the mechanism for the observed microsomal chemiluminescence of benzo[a]pyrene 7,8-dihydrodiol, the proximate carcinogenic metabolite of benzo[a]pyrene. This MVP analog has been found to be a highly efficient and specific chemiluminescent probe for picomole quantities of singlet oxygen and singlet oxygen equivalents, and it produces significant chemiluminescence when reacted with cytochrome P-450 enzymes.

Original languageEnglish (US)
Pages (from-to)869-873
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume123
Issue number2
DOIs
StatePublished - Sep 17 1984

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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