A chemiluminescent probe specific for singlet oxygen

Gary H. Posner; John R. Lever; Kyo Miura; Carol Lisek; Howard H. Seliger; Ambler Thompson

doi:10.1016/0006-291X(84)90311-5

A chemiluminescent probe specific for singlet oxygen

Gary H. Posner, John R. Lever, Kyo Miura, Carol Lisek, Howard H. Seliger, Ambler Thompson

School of Medicine

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

We have synthesized a methoxyvinylpyrene (MVP) in order to model the mechanism for the observed microsomal chemiluminescence of benzo[a]pyrene 7,8-dihydrodiol, the proximate carcinogenic metabolite of benzo[a]pyrene. This MVP analog has been found to be a highly efficient and specific chemiluminescent probe for picomole quantities of singlet oxygen and singlet oxygen equivalents, and it produces significant chemiluminescence when reacted with cytochrome P-450 enzymes.

Original language	English (US)
Pages (from-to)	869-873
Number of pages	5
Journal	Biochemical and Biophysical Research Communications
Volume	123
Issue number	2
DOIs	https://doi.org/10.1016/0006-291X(84)90311-5
State	Published - Sep 17 1984

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/0006-291X(84)90311-5

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abstract = "We have synthesized a methoxyvinylpyrene (MVP) in order to model the mechanism for the observed microsomal chemiluminescence of benzo[a]pyrene 7,8-dihydrodiol, the proximate carcinogenic metabolite of benzo[a]pyrene. This MVP analog has been found to be a highly efficient and specific chemiluminescent probe for picomole quantities of singlet oxygen and singlet oxygen equivalents, and it produces significant chemiluminescence when reacted with cytochrome P-450 enzymes.",

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AU - Posner, Gary H.

AU - Lever, John R.

AU - Miura, Kyo

AU - Lisek, Carol

AU - Seliger, Howard H.

AU - Thompson, Ambler

PY - 1984/9/17

Y1 - 1984/9/17

N2 - We have synthesized a methoxyvinylpyrene (MVP) in order to model the mechanism for the observed microsomal chemiluminescence of benzo[a]pyrene 7,8-dihydrodiol, the proximate carcinogenic metabolite of benzo[a]pyrene. This MVP analog has been found to be a highly efficient and specific chemiluminescent probe for picomole quantities of singlet oxygen and singlet oxygen equivalents, and it produces significant chemiluminescence when reacted with cytochrome P-450 enzymes.

AB - We have synthesized a methoxyvinylpyrene (MVP) in order to model the mechanism for the observed microsomal chemiluminescence of benzo[a]pyrene 7,8-dihydrodiol, the proximate carcinogenic metabolite of benzo[a]pyrene. This MVP analog has been found to be a highly efficient and specific chemiluminescent probe for picomole quantities of singlet oxygen and singlet oxygen equivalents, and it produces significant chemiluminescence when reacted with cytochrome P-450 enzymes.

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JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 2

ER -

A chemiluminescent probe specific for singlet oxygen

Abstract

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