A charge-deficient analogue of spermine with chelating properties

A. R. Khomutov, N. A. Grigorenko, S. G. Skuridin, A. V. Demin, J. Vepsalainen, R. A. Casero, P. M. Woster

Research output: Contribution to journalArticlepeer-review

Abstract

1,12-Diamino-3,6,9-triazadodecane, a new isosteric and charge-deficient analogue of spermine, is synthesized. Unlike spermine, the new analogue is an excellent chelator of Cu2+ ions. Possible applications of this compound for studying enzymes of polyamine metabolism and cellular functions of spermine are discussed.

Original languageEnglish (US)
Pages (from-to)271-278
Number of pages8
JournalRussian Journal of Bioorganic Chemistry
Volume31
Issue number3
DOIs
StatePublished - May 2005

Keywords

  • DNA
  • Polyamines
  • Spermine

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry

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