A charge-deficient analogue of spermine with chelating properties

A. R. Khomutov; N. A. Grigorenko; S. G. Skuridin; A. V. Demin; J. Vepsalainen; R. A. Casero; P. M. Woster

doi:10.1007/s11171-005-0037-1

A charge-deficient analogue of spermine with chelating properties

A. R. Khomutov, N. A. Grigorenko, S. G. Skuridin, A. V. Demin, J. Vepsalainen, R. A. Casero, P. M. Woster

School of Medicine

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

1,12-Diamino-3,6,9-triazadodecane, a new isosteric and charge-deficient analogue of spermine, is synthesized. Unlike spermine, the new analogue is an excellent chelator of Cu²⁺ ions. Possible applications of this compound for studying enzymes of polyamine metabolism and cellular functions of spermine are discussed.

Original language	English (US)
Pages (from-to)	271-278
Number of pages	8
Journal	Russian Journal of Bioorganic Chemistry
Volume	31
Issue number	3
DOIs	https://doi.org/10.1007/s11171-005-0037-1
State	Published - May 2005

Keywords

DNA
Polyamines
Spermine

ASJC Scopus subject areas

Biochemistry
Organic Chemistry

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10.1007/s11171-005-0037-1

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@article{e29d99229d20445890afa14a1cbb2aac,

title = "A charge-deficient analogue of spermine with chelating properties",

abstract = "1,12-Diamino-3,6,9-triazadodecane, a new isosteric and charge-deficient analogue of spermine, is synthesized. Unlike spermine, the new analogue is an excellent chelator of Cu2+ ions. Possible applications of this compound for studying enzymes of polyamine metabolism and cellular functions of spermine are discussed.",

keywords = "DNA, Polyamines, Spermine",

author = "Khomutov, {A. R.} and Grigorenko, {N. A.} and Skuridin, {S. G.} and Demin, {A. V.} and J. Vepsalainen and Casero, {R. A.} and Woster, {P. M.}",

note = "Funding Information: This work was supported by the Russian Foundation for Basic Research, project nos. 03-04-49080 and 03-04-48212, and NCI grant R01 CA 85509.",

year = "2005",

month = may,

doi = "10.1007/s11171-005-0037-1",

language = "English (US)",

volume = "31",

pages = "271--278",

journal = "Russian Journal of Bioorganic Chemistry",

issn = "1068-1620",

publisher = "Maik Nauka-Interperiodica Publishing",

number = "3",

}

TY - JOUR

T1 - A charge-deficient analogue of spermine with chelating properties

AU - Khomutov, A. R.

AU - Grigorenko, N. A.

AU - Skuridin, S. G.

AU - Demin, A. V.

AU - Vepsalainen, J.

AU - Casero, R. A.

AU - Woster, P. M.

N1 - Funding Information: This work was supported by the Russian Foundation for Basic Research, project nos. 03-04-49080 and 03-04-48212, and NCI grant R01 CA 85509.

PY - 2005/5

Y1 - 2005/5

N2 - 1,12-Diamino-3,6,9-triazadodecane, a new isosteric and charge-deficient analogue of spermine, is synthesized. Unlike spermine, the new analogue is an excellent chelator of Cu2+ ions. Possible applications of this compound for studying enzymes of polyamine metabolism and cellular functions of spermine are discussed.

AB - 1,12-Diamino-3,6,9-triazadodecane, a new isosteric and charge-deficient analogue of spermine, is synthesized. Unlike spermine, the new analogue is an excellent chelator of Cu2+ ions. Possible applications of this compound for studying enzymes of polyamine metabolism and cellular functions of spermine are discussed.

KW - DNA

KW - Polyamines

KW - Spermine

UR - http://www.scopus.com/inward/record.url?scp=21544473835&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=21544473835&partnerID=8YFLogxK

U2 - 10.1007/s11171-005-0037-1

DO - 10.1007/s11171-005-0037-1

M3 - Article

AN - SCOPUS:21544473835

SN - 1068-1620

VL - 31

SP - 271

EP - 278

JO - Russian Journal of Bioorganic Chemistry

JF - Russian Journal of Bioorganic Chemistry

IS - 3

ER -

A charge-deficient analogue of spermine with chelating properties

Abstract

Keywords

ASJC Scopus subject areas

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