A challenging diagnosis of penile sarcomatoid squamous cell carcinoma

Sophia Zhang, Hasan Khosravi, Michael Cardis, Jaroslaw Jedrych, Jonhan Ho, Yuri Bunimovich

Research output: Contribution to journalArticlepeer-review


We report a patient with penile sarcomatoid squamous cell carcinoma (SCC) initially misdiagnosed as condyloma acuminatum. Sarcomatoid SCC is a rare, aggressive, biphasic cancer that often presents a diagnostic challenge and carries a poor prognosis, especially after a delay in diagnosis. Although sarcomatoid SCC may exhibit a broad range of clinical features, the expression of p63 and keratin 34βE12 is a common finding. Our case highlights the importance of accurate clinicopathologic correlation to facilitate a timely diagnosis and management of this rare and highly aggressive malignancy.

Original languageEnglish (US)
Article numberA375
JournalDermatology online journal
Issue number10
StatePublished - 2019
Externally publishedYes


  • Sarcomatoid squamous cell carcinoma
  • Squamous cell carcinoma

ASJC Scopus subject areas

  • Dermatology


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