Abstract
Photoreceptors of the lizard parietal eye, unlike rods and cones but like most invertebrate photoreceptors, respond to light under dark-adapted conditions with a depolarization. Using excised-patch recordings: we have nonetheless found a cGMP-gated, non-selective cation channel present at high density at the presumptive light-sensitive part (the outer segment) of these cells. This channel resembles the rod cGMP-gated channel in its activation characteristics, and by showing a relative non-selectivity among alkali monovalent cations, a high permeability to Ca2+, a high sensitivity to L-cis-diltiazem, as well as a negative modulation by Ca2+-calmodulin. This channel appears to mediate phototransduction by opening in the light to produce the depolarizing response.
Original language | English (US) |
---|---|
Pages (from-to) | 1353-1357 |
Number of pages | 5 |
Journal | Vision Research |
Volume | 38 |
Issue number | 10 |
DOIs | |
State | Published - May 1998 |
Keywords
- Parietal eye
- Photoreceptor
- Phototransduction
- cGMP
- cGMP-gated channel
ASJC Scopus subject areas
- Ophthalmology
- Sensory Systems