A centromere-based genetic map of the short arm of human chromosome 6

Helene Blanché, Huda Y. Zoghbi, Ethylin Wang Jabs, Beatrice de Gouyon, Renata Zunec, Jean Dausset, Howard M. Cann

Research output: Contribution to journalArticlepeer-review

Abstract

A genetic map of the short arm of chromosome 6 (6p) has been constructed with 20 genetic markers that define 16 loci, including a locus at the centromere. The 40 CEPH families and, for 4 loci, 13 additional Utah families were genotyped. All 16 loci form a single linkage group extending from near the telomeric region to the centromere, covering 159 cM (Haldane) on the female map and 94 cM on the male map. Sex differences in recombination frequencies are noted for the 6p map, with an excess occurring in males at the distal end. The genetic order of loci is consistent with their physical localization on 6p. Proximal to the three most distal loci on the map, markers are especially dense, providing an extended region on 6p useful for localizing genes of interest.

Original languageEnglish (US)
Pages (from-to)420-428
Number of pages9
JournalGenomics
Volume9
Issue number3
DOIs
StatePublished - 1991
Externally publishedYes

ASJC Scopus subject areas

  • Genetics

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