A cellular model for hemoglobin switching

B. P. Alter, D. G. Nathan

Research output: Contribution to journalArticlepeer-review


The switch from Hb F to A which occurs during ontogeny in primates is incomplete in the adult. In addition, Hb F may reappear during erythroid stress. Colonies derived in vitro from erythroid progenitors also produce both Hbs F and A. At each stage of normal ontogeny, the relation between the proportion of F synthesized in the colonies derived from progenitors in vitro and in the reticulocytes or erythroblasts (precursors) which developed in vivo is not immediately apparent. There are several possible models to explain the phenomenon of the ontogenic switch. A cellular model is presented.

Original languageEnglish (US)
Pages (from-to)111-116
Number of pages6
JournalBirth Defects: Original Article Series
Issue number7
StatePublished - 1982
Externally publishedYes

ASJC Scopus subject areas

  • Developmental Biology
  • Genetics(clinical)


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