A catalytic antibody elicited by a hapten of tetrahedral carbon-type

Tomoya Kitazume, Takashi Tsukamoto, Koutaro Yoshimura

Research output: Contribution to journalArticlepeer-review

Abstract

A monoclonal antibody, elicited by a α,α,α′, α′-tetrafluoroketone hapten, acted as an enzyme-like catalyst for the hydrolysis of an analogous carbonate, demonstrating that the difluoromethylene unit can been used as an isostere and isoelectronic mimic for the oxygen atom in an ether.

Original languageEnglish (US)
Pages (from-to)1355-1356
Number of pages2
JournalJournal of the Chemical Society, Chemical Communications
Issue number11
DOIs
StatePublished - Dec 1 1994
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Medicine

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