A monoclonal antibody, elicited by a α,α,α′, α′-tetrafluoroketone hapten, acted as an enzyme-like catalyst for the hydrolysis of an analogous carbonate, demonstrating that the difluoromethylene unit can been used as an isostere and isoelectronic mimic for the oxygen atom in an ether.
|Original language||English (US)|
|Number of pages||2|
|Journal||Journal of the Chemical Society, Chemical Communications|
|State||Published - Dec 1 1994|
ASJC Scopus subject areas
- Molecular Medicine