A case study of a child with chronic hemolytic anemia due to a Donath-Landsteiner positive, IgM anti-I autoantibody

Matthew S. Karafin, R. Sue Shirey, Paul Michael Ness, Karen Eileen King, Jeffrey Keefer

Research output: Contribution to journalArticle

Abstract

In children, paroxysmal cold hemoglobinuria (PCH) is generally considered an acute self-limited autoimmune hemolytic anemia caused by an IgG biphasic auto-anti-P antibody identified by the Donath-Landsteiner (D-L) test. We report a case of a 5-year-old female with a chronic hemolytic anemia. The etiology of the hemolysis appears to be an unusual D-L positive, IgM antibody with specificity for the I antigen. The clinical course is described and a discussion of PCH and the D-L antibody is presented. We also discuss intravenous immunoglobulin infusions as a therapy for children with this form of severe chronic autoimmune hemolytic anemia.

Original languageEnglish (US)
Pages (from-to)953-955
Number of pages3
JournalPediatric Blood and Cancer
Volume59
Issue number5
DOIs
StatePublished - Nov 2012

Fingerprint

Paroxysmal Hemoglobinuria
Autoimmune Hemolytic Anemia
Hemolytic Anemia
Autoantibodies
Antibody Specificity
Intravenous Immunoglobulins
Hemolysis
Intravenous Infusions
Immunoglobulin M
Anti-Idiotypic Antibodies
Immunoglobulin G
anti-IgM
Therapeutics
I-antigen
Donath-Landsteiner antibody

Keywords

  • Anemias
  • Blood bank
  • Hemolytic anemia
  • Immunotherapy
  • IVIG

ASJC Scopus subject areas

  • Oncology
  • Pediatrics, Perinatology, and Child Health
  • Hematology

Cite this

A case study of a child with chronic hemolytic anemia due to a Donath-Landsteiner positive, IgM anti-I autoantibody. / Karafin, Matthew S.; Shirey, R. Sue; Ness, Paul Michael; King, Karen Eileen; Keefer, Jeffrey.

In: Pediatric Blood and Cancer, Vol. 59, No. 5, 11.2012, p. 953-955.

Research output: Contribution to journalArticle

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