A Case Report and Systematic Review of Eosinophilic Angiocentric Fibrosis of the Paranasal Sinuses

Molly E. Heft Neal, Nicholas R. Rowan, Thomas J. Willson, Eric W. Wang, Stella E. Lee

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations


Objective: There is a paucity of literature discussing prognostic factors or comparing outcomes in eosinophilic angiocentric fibrosis (EAF). This review aims to analyze tumor and patient characteristics as possible prognostic markers and compare surgical approaches. Methods: Systematic literature review and case report analyzing available cases of EAF located within the paranasal sinuses. Results: The literature search yielded 39 articles meeting criteria for a total of 59 cases (including 1 from our institution). Median patient age was 46 years. The most common presenting symptoms were nasal obstruction (69%, n = 41) and change in external nasal appearance (39%, n = 32). The majority of cases (85%) were treated with surgical resection alone or in combination with medication. Of surgical patients, 62% underwent a complete resection with a recurrence rate of 20%. Median follow-up duration was 2 years. Endoscopic approach showed a significant positive correlation with complete resection (P =.045). Patient sex (P =.6), tumor location (range, P =.32-.98), lateral rhinotomy (P =.26), septoplasty (P =.84), and external rhinoplasty (P =.28) were not significantly correlated with total resection. Insufficient sample size precluded calculation of predictors of recurrence following surgery. Conclusion: This review suggests that an endoscopic approach to EAF tumor is a viable option, frequently yielding complete resection.

Original languageEnglish (US)
Pages (from-to)415-423
Number of pages9
JournalAnnals of Otology, Rhinology and Laryngology
Issue number5
StatePublished - May 1 2017
Externally publishedYes


  • endoscopic sinus surgery
  • eosinophilic angiocentric fibrosis
  • eosinophilic inflammation of nose
  • nasal mass
  • surgical outcomes

ASJC Scopus subject areas

  • Otorhinolaryngology


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