A case of orbital apex syndrome caused by localized invasive aspergillosis successfully treated with voriconazole

Atsushi Kuga, Kenichi Oishi, Haruhiko Ishida, Fumio Kanda

Research output: Contribution to journalArticle

Abstract

A 71-year-old man with left periorbital pain and diplopia was hospitalized for evaluation and treatment. He had a past history of untreated diabetes mellitus. Shortly after admission, the patient experienced rapid onset of visual loss in the left eye. MRI and CT showed a lesion expanding from the left orbital apex to the left pterygopalatine fossa. Invasive aspergillosis was diagnosed by open biopsy of intrasinus mucosa via the left maxillary sinus. The patient was treated with voriconazole, an antifungal agent, and marked improvements in left periorbital pain and eye movement were subsequently obtained, although visual acuity was not recovered. This is the first report documenting the clinical utility of voriconazole for sino-orbital invasive aspergillosis.

Original languageEnglish (US)
Pages (from-to)207-210
Number of pages4
JournalClinical Neurology
Volume47
Issue number5
StatePublished - May 2007
Externally publishedYes

Fingerprint

Aspergillosis
Pterygopalatine Fossa
Pain
Diplopia
Maxillary Sinus
Antifungal Agents
Patient Admission
Eye Movements
Visual Acuity
Diabetes Mellitus
Mucous Membrane
Biopsy
Voriconazole
Therapeutics

Keywords

  • Aspergillus
  • Orbital apex syndrome
  • Voriconazole

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

A case of orbital apex syndrome caused by localized invasive aspergillosis successfully treated with voriconazole. / Kuga, Atsushi; Oishi, Kenichi; Ishida, Haruhiko; Kanda, Fumio.

In: Clinical Neurology, Vol. 47, No. 5, 05.2007, p. 207-210.

Research output: Contribution to journalArticle

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