A case of Ollier's disease associated with two intracranial gliomas

C. E. Rawlings, D. E. Bullard, P. C. Burger, A. H. Friedman

Research output: Contribution to journalReview articlepeer-review

Abstract

Ollier's disease or multiple enchondromatosis is a deforming dysplastic disease of cartilage involving primarily the metaphyses and diaphyses of long bone. It is only rarely associated with sarcomatous degeneration of the enchondromas or other generalized neoplasms. A related disease, Maffucci's syndrome, is, however, associated with generalized tumors. We present the case of a 29-year-old, albino, black man with Ollier's disease who, as a child, underwent a number of orthopedic procedures for multiple limb deformities and fractures. At age 25, he developed hydrocephalus, progressive cranial nerve palsies, and a large enchondroma of the skull base. He subsequently underwent multiple shunt procedures and two suboccipital craniectomies. Eighteen months later, a brain computed tomographic (CT) scan revealed an intracerebellar mass, which was found to be an anaplastic astrocytoma. Two years later, he developed a right hemiparesis and sensory dysfunction with a diffuse supratentorial mass on CT scan. A stereotactic biopsy showed this to be a similar anaplastic astrocytoma. The literature concerning Ollier's disease is reviewed, and the intracerebral lesions associated with both Ollier's disease and Maffucci's syndrome are examined.

Original languageEnglish (US)
Pages (from-to)400-403
Number of pages4
JournalNeurosurgery
Volume21
Issue number3
DOIs
StatePublished - Jan 1 1987

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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