A Case of Mistaken Identity? Nonductal Origins of Pancreatic "Ductal" Cancers

L. Charles Murtaugh, Steven D. Leach

Research output: Contribution to journalShort surveypeer-review

Abstract

In this issue of Cancer Cell, Guerra and colleagues provide important new insights regarding the ability of specific pancreatic cell types to generate invasive pancreatic cancer. First, they demonstrate that classical pancreatic "ductal" neoplasia can be induced by activation of oncogenic Kras in nonductal exocrine cells. Second, they show that, while Kras activation in immature acinar and centroacinar cells is readily able to induce ductal neoplasia, Kras-mediated tumorigenesis in mature exocrine pancreas requires the induction of chronic epithelial injury. The results shed new light on the "cell of origin" of pancreatic ductal cancer and demonstrate that chronic pancreatitis provides a permissive environment for Kras-induced pancreatic neoplasia.

Original languageEnglish (US)
Pages (from-to)211-213
Number of pages3
JournalCancer cell
Volume11
Issue number3
DOIs
StatePublished - Mar 13 2007

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research

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