TY - JOUR
T1 - A case of equine granulocytic ehrlichiosis provides molecular evidence for the presence of pathogenic Anaplasma phagocytophilum (HGE agent) in Germany
AU - Von Loewenich, F. D.
AU - Stumpf, G.
AU - Baumgarten, B. U.
AU - Röllinghoff, M.
AU - Dumler, J. S.
AU - Bogdan, C.
N1 - Funding Information:
Acknowledgements This work was supported by grants from the German Ministry for Education and Research, the Interdisciplinary Center for Clinical Research of the Friedrich-Alexander University Erlangen (Project A14) and from the German Research Foundation (SFB263 project A5).
PY - 2003/5/1
Y1 - 2003/5/1
N2 - Based on seroprevalence studies and tick infection rates, tick-borne human granulocytic ehrlichiosis (HGE) is thought to occur in Germany, but to date no clinical case has been detected. Reported here are the first ehrlichial sequences derived from a German horse that fell ill with granulocytic ehrlichiosis. The analysis of three different genes (16S rRNA gene, groESL, and ankA) revealed up to 100% identity with ehrlichial sequences derived from patients with HGE in other countries or from infected ticks in Germany. Thus, the current lack of clinical cases of HGE in Germany is unlikely to result from the absence of pathogenic granulocytic ehrlichiae strains in German ticks.
AB - Based on seroprevalence studies and tick infection rates, tick-borne human granulocytic ehrlichiosis (HGE) is thought to occur in Germany, but to date no clinical case has been detected. Reported here are the first ehrlichial sequences derived from a German horse that fell ill with granulocytic ehrlichiosis. The analysis of three different genes (16S rRNA gene, groESL, and ankA) revealed up to 100% identity with ehrlichial sequences derived from patients with HGE in other countries or from infected ticks in Germany. Thus, the current lack of clinical cases of HGE in Germany is unlikely to result from the absence of pathogenic granulocytic ehrlichiae strains in German ticks.
UR - http://www.scopus.com/inward/record.url?scp=0037523346&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037523346&partnerID=8YFLogxK
U2 - 10.1007/s10096-003-0935-1
DO - 10.1007/s10096-003-0935-1
M3 - Article
C2 - 12740667
AN - SCOPUS:0037523346
SN - 0934-9723
VL - 22
SP - 303
EP - 305
JO - European Journal of Clinical Microbiology and Infectious Diseases
JF - European Journal of Clinical Microbiology and Infectious Diseases
IS - 5
ER -