A case of autoimmune retinopathy associated with thyroid carcinoma

Nicole Mahdi; Lisa J. Faia; James Goodwin; Robert B. Nussenblatt; H. Nida Sen

doi:10.3109/09273941003802379

A case of autoimmune retinopathy associated with thyroid carcinoma

Nicole Mahdi, Lisa J. Faia, James Goodwin, Robert B. Nussenblatt, H. Nida Sen

Research output: Contribution to journal › Article › peer-review

Abstract

Purpose: To report a case of autoimmune retinopathy (AIR) associated with a thyroid carcinoma. Design: Case report. Method: A 51-year-old Caucasian woman presented with a rapid decline in vision. Initial visual field and immunohistochemical testing revealed autoimmune retinopathy without an apparent underlying malignancy. Conventional local and systemic immunosuppressive therapies failed to halt the progression. Results: Rituximab treatments were initiated and a slowing of visual loss was seen. Continued surveillance for malignancy revealed a thyroid adenoma, and later a thyroidectomy revealed a thyroid carcinoma. Conclusions: This report highlights the unique presentation of AIR associated with a thyroid carcinoma, the need for continued surveillance for malignancy in cases of AIR, and the possible new use of rituximab for the treatment of AIR.

Original language	English (US)
Pages (from-to)	322-323
Number of pages	2
Journal	Ocular Immunology and Inflammation
Volume	18
Issue number	4
DOIs	https://doi.org/10.3109/09273941003802379
State	Published - Aug 2010
Externally published	Yes

Keywords

Autoantibodies
Autoimmune retinopathy
Electroretinogram (ERG)
Rituxumab
Thyroid carcinoma

ASJC Scopus subject areas

Immunology and Allergy
Ophthalmology

Access to Document

10.3109/09273941003802379

Cite this

@article{514771609b64444c85c6519289025e95,

title = "A case of autoimmune retinopathy associated with thyroid carcinoma",

abstract = "Purpose: To report a case of autoimmune retinopathy (AIR) associated with a thyroid carcinoma. Design: Case report. Method: A 51-year-old Caucasian woman presented with a rapid decline in vision. Initial visual field and immunohistochemical testing revealed autoimmune retinopathy without an apparent underlying malignancy. Conventional local and systemic immunosuppressive therapies failed to halt the progression. Results: Rituximab treatments were initiated and a slowing of visual loss was seen. Continued surveillance for malignancy revealed a thyroid adenoma, and later a thyroidectomy revealed a thyroid carcinoma. Conclusions: This report highlights the unique presentation of AIR associated with a thyroid carcinoma, the need for continued surveillance for malignancy in cases of AIR, and the possible new use of rituximab for the treatment of AIR.",

keywords = "Autoantibodies, Autoimmune retinopathy, Electroretinogram (ERG), Rituxumab, Thyroid carcinoma",

author = "Nicole Mahdi and Faia, {Lisa J.} and James Goodwin and Nussenblatt, {Robert B.} and {Nida Sen}, H.",

year = "2010",

month = aug,

doi = "10.3109/09273941003802379",

language = "English (US)",

volume = "18",

pages = "322--323",

journal = "Ocular Immunology and Inflammation",

issn = "0927-3948",

publisher = "Informa Healthcare",

number = "4",

}

TY - JOUR

T1 - A case of autoimmune retinopathy associated with thyroid carcinoma

AU - Mahdi, Nicole

AU - Faia, Lisa J.

AU - Goodwin, James

AU - Nussenblatt, Robert B.

AU - Nida Sen, H.

PY - 2010/8

Y1 - 2010/8

N2 - Purpose: To report a case of autoimmune retinopathy (AIR) associated with a thyroid carcinoma. Design: Case report. Method: A 51-year-old Caucasian woman presented with a rapid decline in vision. Initial visual field and immunohistochemical testing revealed autoimmune retinopathy without an apparent underlying malignancy. Conventional local and systemic immunosuppressive therapies failed to halt the progression. Results: Rituximab treatments were initiated and a slowing of visual loss was seen. Continued surveillance for malignancy revealed a thyroid adenoma, and later a thyroidectomy revealed a thyroid carcinoma. Conclusions: This report highlights the unique presentation of AIR associated with a thyroid carcinoma, the need for continued surveillance for malignancy in cases of AIR, and the possible new use of rituximab for the treatment of AIR.

AB - Purpose: To report a case of autoimmune retinopathy (AIR) associated with a thyroid carcinoma. Design: Case report. Method: A 51-year-old Caucasian woman presented with a rapid decline in vision. Initial visual field and immunohistochemical testing revealed autoimmune retinopathy without an apparent underlying malignancy. Conventional local and systemic immunosuppressive therapies failed to halt the progression. Results: Rituximab treatments were initiated and a slowing of visual loss was seen. Continued surveillance for malignancy revealed a thyroid adenoma, and later a thyroidectomy revealed a thyroid carcinoma. Conclusions: This report highlights the unique presentation of AIR associated with a thyroid carcinoma, the need for continued surveillance for malignancy in cases of AIR, and the possible new use of rituximab for the treatment of AIR.

KW - Autoantibodies

KW - Autoimmune retinopathy

KW - Electroretinogram (ERG)

KW - Rituxumab

KW - Thyroid carcinoma

UR - http://www.scopus.com/inward/record.url?scp=77954878899&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77954878899&partnerID=8YFLogxK

U2 - 10.3109/09273941003802379

DO - 10.3109/09273941003802379

M3 - Article

C2 - 20662664

AN - SCOPUS:77954878899

SN - 0927-3948

VL - 18

SP - 322

EP - 323

JO - Ocular Immunology and Inflammation

JF - Ocular Immunology and Inflammation

IS - 4

ER -

A case of autoimmune retinopathy associated with thyroid carcinoma

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this