A case in which TS-1, an orally-administered 5-FU chemotherapeutic agent, showed marked effectiveness against scirrhous type gastric cancer with multiple organ metastases

Osamu Yanagida, Masanori Teruya, Kaoru Kobayashi, Akihiko Itou, Jun ichi Naganuma, Reiji Asakura, Shunji Araki

Research output: Contribution to journalArticle

Abstract

A 67-year-old woman with anorexia and weight loss was referred to our hospital with a diagnosis of type 4 gastric cancer. Since metastases to the liver, left adrenal gland, and Douglas' pouch were detected in addition to ascites and bilateral hydronephrosis, the tumor was judged unresectable and systemic chemotherapy with TS-1 was begun. Symptoms began to improve after the first course, and the patient was discharged and followed as an outpatient. An upper GI series showed improvement of the primary lesion, and cancer cells became undetectable under biopsy. At the end of the third course, computed tomography confirmed that metastases to the liver, the lymph nodes, and the adrenal gland had disappeared. The ascites diminished significantly, and hydronephrosis began to ameliorate. The effectiveness of the drug continued until the end of the eleventh course, and the patient is currently in her seventeenth month as an outpatient. This case shows the effectiveness of TS-1 against scirrhous type gastric cancer, a cancer generally considered resistant to chemotherapy. Furthermore, treatment on an outpatient basis has greatly improved her quality of life.

Original languageEnglish (US)
Pages (from-to)761-764
Number of pages4
JournalJapanese Journal of Cancer and Chemotherapy
Volume29
Issue number5
StatePublished - May 2002
Externally publishedYes

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Fluorouracil
Stomach Neoplasms
Outpatients
Hydronephrosis
Adrenal Glands
Neoplasm Metastasis
Ascites
Douglas' Pouch
Drug Therapy
Neoplasms
Liver
Anorexia
Weight Loss
Lymph Nodes
Tomography
Quality of Life
Biopsy
Pharmaceutical Preparations
titanium silicide
Therapeutics

ASJC Scopus subject areas

  • Cancer Research
  • Pharmacology

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A case in which TS-1, an orally-administered 5-FU chemotherapeutic agent, showed marked effectiveness against scirrhous type gastric cancer with multiple organ metastases. / Yanagida, Osamu; Teruya, Masanori; Kobayashi, Kaoru; Itou, Akihiko; Naganuma, Jun ichi; Asakura, Reiji; Araki, Shunji.

In: Japanese Journal of Cancer and Chemotherapy, Vol. 29, No. 5, 05.2002, p. 761-764.

Research output: Contribution to journalArticle

Yanagida, Osamu ; Teruya, Masanori ; Kobayashi, Kaoru ; Itou, Akihiko ; Naganuma, Jun ichi ; Asakura, Reiji ; Araki, Shunji. / A case in which TS-1, an orally-administered 5-FU chemotherapeutic agent, showed marked effectiveness against scirrhous type gastric cancer with multiple organ metastases. In: Japanese Journal of Cancer and Chemotherapy. 2002 ; Vol. 29, No. 5. pp. 761-764.
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