A case control study of proximal calciphylaxis

Anthony J. Bleyer, Michael J Choi, Benjamin Igwemezie, Ernesto De La Torre, Wain L. White

Research output: Contribution to journalArticle

Abstract

The purpose of this investigation was to describe the clinical presentation of nine patients with calciphylaxis involving the proximal lower extremities or trunk and to compare the clinical characteristics of these patients with those of 347 hemodialysis patients from the same geographic area. Patients were identified primarily through a computer search of pathology records, identifying patients with the term 'calciphylaxis' in the biopsy report. All patients had pathologic specimens consistent with calciphylaxis. All the calciphylaxis patients were white and were markedly obese. While two patients had markedly elevated parathyroid hormone levels, most patients did not show severe derangements of calcium phosphate metabolism compared with other dialysis patients. A logistic regression model identified body mass index and low serum albumin 3 months before diagnosis as being highly associated with a diagnosis of calciphylaxis. Diabetes mellitus and parameters of calcium-phosphate metabolism were not significantly associated with proximal calciphylaxis. These findings suggest that white race, morbid obesity, and poor nutritional status are associated with proximal calciphylaxis in dialysis patients.

Original languageEnglish (US)
Pages (from-to)376-383
Number of pages8
JournalAmerican Journal of Kidney Diseases
Volume32
Issue number3
StatePublished - Sep 1998
Externally publishedYes

Fingerprint

Calciphylaxis
Case-Control Studies
Dialysis
Logistic Models
Morbid Obesity
Nutritional Status
Parathyroid Hormone
Serum Albumin
Renal Dialysis
Lower Extremity
Diabetes Mellitus

Keywords

  • Calciphylaxis
  • Hemodialysis
  • Human
  • Obesity
  • Proximal

ASJC Scopus subject areas

  • Nephrology

Cite this

Bleyer, A. J., Choi, M. J., Igwemezie, B., De La Torre, E., & White, W. L. (1998). A case control study of proximal calciphylaxis. American Journal of Kidney Diseases, 32(3), 376-383.

A case control study of proximal calciphylaxis. / Bleyer, Anthony J.; Choi, Michael J; Igwemezie, Benjamin; De La Torre, Ernesto; White, Wain L.

In: American Journal of Kidney Diseases, Vol. 32, No. 3, 09.1998, p. 376-383.

Research output: Contribution to journalArticle

Bleyer, AJ, Choi, MJ, Igwemezie, B, De La Torre, E & White, WL 1998, 'A case control study of proximal calciphylaxis', American Journal of Kidney Diseases, vol. 32, no. 3, pp. 376-383.
Bleyer AJ, Choi MJ, Igwemezie B, De La Torre E, White WL. A case control study of proximal calciphylaxis. American Journal of Kidney Diseases. 1998 Sep;32(3):376-383.
Bleyer, Anthony J. ; Choi, Michael J ; Igwemezie, Benjamin ; De La Torre, Ernesto ; White, Wain L. / A case control study of proximal calciphylaxis. In: American Journal of Kidney Diseases. 1998 ; Vol. 32, No. 3. pp. 376-383.
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