A case-control study of aplastic anemia

Martha S. Linet, Jan A. Markowitz, Lyle L. Sensenbrenner, Steven G. Warm, Sally Weida, Mark L. Van Natta, Moyses Szklo

Research output: Contribution to journalArticle

Abstract

A case-control interview study of aplastic anemia was conducted to evaluate suspected risk factors. Cases (N = 59) newly diagnosed during 1975-1982 at 25 Baltimore area hospitals were compared with 59 individually matched (on age, sex and race) controls selected by random digit dialing. The average educational level was less for cases than controls. The major job-related findings were a significant excess for occupational exposure to paint (OR = 6.1; 95% C.I. = 1.2-29.7), further substantiated by a positive dose-response relationship, although painters were not at excess risk. An increased risk of occupational exposure to viruses (OR = 9.0; 95% C.I. = 0.8-105.6) was noted. Additional evidence implicating viral factors included a significant association with prior history of hepatitis (OR = 9.0; 95% C.I. = 1.0, 84.2) and an elevated risk for pre-diagnostic receipt of blood transfusions (OR = 7.1; 95% C.I. = 0.7-68.4). Risks were not increased for other occupational, residential, personal, or medical treatment exposures or for other viral infections, medical conditions, smoking or alcohol consumption prior to diagnosis. Because of the small number of subjects studied and the multiple comparisons examined, these findings should be interpreted cautiously and confirmation should be undertaken in larger, population-based studies.

Original languageEnglish (US)
Pages (from-to)3-11
Number of pages9
JournalLeukemia Research
Volume13
Issue number1
DOIs
StatePublished - 1989

Keywords

  • Aplastic anemia
  • etiology
  • retrospective study

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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  • Cite this

    Linet, M. S., Markowitz, J. A., Sensenbrenner, L. L., Warm, S. G., Weida, S., Van Natta, M. L., & Szklo, M. (1989). A case-control study of aplastic anemia. Leukemia Research, 13(1), 3-11. https://doi.org/10.1016/0145-2126(89)90025-8