TY - JOUR
T1 - A case control etiologic study of sarcoidosis
T2 - Environmental and occupational risk factors
AU - Newman, Lee S.
AU - Rose, Cecile S.
AU - Bresnitz, Eddy A.
AU - Rossman, Milton D.
AU - Barnard, Juliana
AU - Frederick, Margaret
AU - Terrin, Michael L.
AU - Weinberger, Steven E.
AU - Moller, David R.
AU - McLennan, Geoffrey
AU - Hunninghake, Gary
AU - DePalo, Louis
AU - Baughman, Robert P.
AU - Iannuzzi, Michael C.
AU - Judson, Marc A.
AU - Knatterud, Genell L.
AU - Thompson, Bruce W.
AU - Teirstein, Alvin S.
AU - Yeager, Henry
AU - Johns, Carol J.
AU - Rabin, David L.
AU - Rybicki, Benjamin A.
AU - Cherniack, Reuben
PY - 2004/12/15
Y1 - 2004/12/15
N2 - Past research suggests that environmental factors may be associated with sarcoidosis risk. We conducted a case control study to test a priori hypotheses that environmental and occupational exposures are associated with sarcoidosis. Ten centers recruited 706 newly diagnosed patients with sarcoidosis and an equal number of age-, race-, and sex-matched control subjects. Interviewers administered questionnaires containing questions regarding occupational and nonoccupational exposures that we assessed in univariable and multivariable analyses. We observed positive associations between sarcoidosis and specific occupations (e.g., agricultural employment, odds ratio [OR] 1.46, confidence interval [CI] 1.13-1.89), exposures (e.g., insecticides at work, OR 1.52, CI 1.14-2.04, and work environments with mold/mildew exposures [environments with possible exposures to microbial bioaerosols], OR 1.61, CI 1.13-2.31). A history of ever smoking cigarettes was less frequent among cases than control subjects (OR 0.62, CI 0.50-0.77). In multivariable modeling, we observed elevated ORs for work in areas with musty odors (OR 1.62, CI 1.24-2.11) and with occupational exposure to insecticides (OR 1.61, CI 1.13-2.28), and a decreased OR related to ever smoking cigarettes (OR 0.65, CI 0.51-0.82). The study did not identify a single, predominant cause of sarcoidosis. We identified several exposures associated with sarcoidosis risk, including insecticides, agricultural employment, and microbial bioaerosols.
AB - Past research suggests that environmental factors may be associated with sarcoidosis risk. We conducted a case control study to test a priori hypotheses that environmental and occupational exposures are associated with sarcoidosis. Ten centers recruited 706 newly diagnosed patients with sarcoidosis and an equal number of age-, race-, and sex-matched control subjects. Interviewers administered questionnaires containing questions regarding occupational and nonoccupational exposures that we assessed in univariable and multivariable analyses. We observed positive associations between sarcoidosis and specific occupations (e.g., agricultural employment, odds ratio [OR] 1.46, confidence interval [CI] 1.13-1.89), exposures (e.g., insecticides at work, OR 1.52, CI 1.14-2.04, and work environments with mold/mildew exposures [environments with possible exposures to microbial bioaerosols], OR 1.61, CI 1.13-2.31). A history of ever smoking cigarettes was less frequent among cases than control subjects (OR 0.62, CI 0.50-0.77). In multivariable modeling, we observed elevated ORs for work in areas with musty odors (OR 1.62, CI 1.24-2.11) and with occupational exposure to insecticides (OR 1.61, CI 1.13-2.28), and a decreased OR related to ever smoking cigarettes (OR 0.65, CI 0.51-0.82). The study did not identify a single, predominant cause of sarcoidosis. We identified several exposures associated with sarcoidosis risk, including insecticides, agricultural employment, and microbial bioaerosols.
KW - Environment
KW - Etiology
KW - Granuloma
KW - Occupation
KW - Risk factors
KW - Sarcoidosis
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U2 - 10.1164/rccm.200402-249OC
DO - 10.1164/rccm.200402-249OC
M3 - Article
C2 - 15347561
AN - SCOPUS:10644294658
VL - 170
SP - 1324
EP - 1330
JO - American Review of Respiratory Disease
JF - American Review of Respiratory Disease
SN - 1073-449X
IS - 12
ER -