A canine model of acute coronary artery thrombosis for the evaluation of reperfusion strategies

Paul A. Gurbel, Christopher S. MacCord, R. David Anderson, Helen Scott, Dan Atar, Wolfgang Mergner, William R. Herzog

Research output: Contribution to journalArticlepeer-review

Abstract

A model of coronary artery thrombosis which: (1) provides a stable thrombus; (2) incorporates intimal injury; (3) has a low mortality rate; (4) responds predictably to thrombolytic therapy, and (5) is technically simple, was developed. Intimal injury was produced proximal to a critical stenosis and followed by the infusion of a blood and thrombin mixture into the injured segment. After thrombus formation flow remained absent in all control animals (n = 7). Microscopy showed intimal injury and coronary thrombosis with platelets adherent to the subendothelium. In animals treated with tissue plasminogen activator (n = 7) flow returned to > 60% of baseline at 20.2 ± 7.7 min and was cyclical. Mortality and complications were infrequent. This model is useful in investigations of reperfusion therapy.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalCardiology (Switzerland)
Volume84
Issue number1
DOIs
StatePublished - Jan 1 1994

Keywords

  • Coronary thrombosis
  • Model
  • Reperfusion
  • Thrombolysis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pharmacology (medical)

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