A candidate molecule approach to defining developmental pathology in schizophrenia

Cynthia Shannon Weickert, Daniel R. Weinberger

Research output: Contribution to journalReview article

Abstract

The evidence that schizophrenia may have its origins from early in life, possibly during prenatal brain development, is based primarily on a constellation of nonspecific anatomical findings and on the results of surveys of obstetrical complications and of childhood neurological and psychological adjustment. The developmental processes implicated by this evidence are uncertain, but speculation has centered around abnormalities of neuronal proliferation, migration, and connection formation. These developmental milestones are the results of complicated cellular processes involving molecular interactions between cells and between the extracellular and intracellular milieus. To understand how these abnormalities could relate to schizophrenia, it is necessary to characterize the molecular events that define the processes. In this article, we discuss the potential impact of a number of molecules that are important in the sequence of cellular events implicated in schizophrenia. In particular, we focus on molecular mechanisms related to cell proliferation, axonal outgrowth, cell migration, cell survival, synaptic regression, myelination, and developmental aspects of early adult life. These various candidate molecules regulate different aspects of cell growth and cell-cell interactions and are involved in the regulation of deoxyribonucleic acid (DNA) expression. Very few of these molecules have been studied in the schizophrenic brain.

Original languageEnglish (US)
Pages (from-to)303-316
Number of pages14
JournalSchizophrenia bulletin
Volume24
Issue number2
DOIs
StatePublished - Jan 1 1998
Externally publishedYes

Keywords

  • Growth factors
  • Hormone receptors
  • Myelination
  • Puberty

ASJC Scopus subject areas

  • Psychiatry and Mental health

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