A 'calcium capacitor' shapes cholinergic inhibition of cochlear hair cells

Research output: Contribution to journalArticle

Abstract

Efferent cholinergic neurons project from the brainstem to inhibit sensory hair cells of the vertebrate inner ear. This inhibitory synapse combines the activity of an unusual class of ionotropic cholinergic receptor with that of nearby calcium-dependent potassium channels to shunt and hyperpolarize the hair cell. Postsynaptic calcium signalling is constrained by a thin near-membrane cistern that is co-extensive with the efferent terminal contacts. The postsynaptic cistern may play an essential role in calcium homeostasis, serving as sink or source, depending on ongoing activity and the degree of buffer saturation. Release of calcium from postsynaptic stores leads to a process of retrograde facilitation via the synthesis of nitric oxide in the hair cell. Activity-dependent synaptic modification may contribute to changes in hair cell innervation that occur during development, and in the aged or damaged cochlea.

Original languageEnglish (US)
Pages (from-to)3393-3401
Number of pages9
JournalJournal of Physiology
Volume592
Issue number16
DOIs
StatePublished - Aug 15 2014

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Auditory Hair Cells
Cholinergic Agents
Calcium
Efferent Neurons
Calcium-Activated Potassium Channels
Cholinergic Neurons
Calcium Signaling
Cochlea
Cholinergic Receptors
Inner Ear
Synapses
Brain Stem
Vertebrates
Buffers
Nitric Oxide
Homeostasis
Membranes

ASJC Scopus subject areas

  • Physiology

Cite this

A 'calcium capacitor' shapes cholinergic inhibition of cochlear hair cells. / Fuchs, Paul Albert.

In: Journal of Physiology, Vol. 592, No. 16, 15.08.2014, p. 3393-3401.

Research output: Contribution to journalArticle

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