@article{04c971f3a846476182890bb2ef795c65,
title = "A brain-specific transcription activator",
abstract = "We have identified a DNA binding protein, named BETA, that interacts with the same (B) transcriptional regulatory sequence as the known transcription factor NF-κB. BETA is found only in gray matter throughout the brain, and not in a variety of other rat tissues. Two binding sites for BETA are present adjacent to the promoter of the rat proenkephalin gene. Transfection of primary brain cultures that express BETA, with a reporter gene driven by the SV40 promoter linked to BETA DNA binding sites, results in transcriptional activation. We infer that that BETA is a brain-specific transcription activator.",
author = "Mira Korner and Amir Rattner and Fabienne Mauxion and Ranjan Sen and Yoav Citri",
note = "Funding Information: We would especially llke to thank Michael Schramm of the Hebrew University of Jerusalem for his encouragement, support, and advice and for his Invaluable help and the use of his laboratory to obtain the primary cultures employed in this study. We would also like to thank Yoram Salomon, Michael Walker, Rafael Malach, Menahem Segal, Varda Grlnberger, Haim Rosen, Yinon Ben-Neriah, Dana Hevroni. Dorit Naot, and Nava Nevo for reagents, cells, and plasmids and for helpful discussions and comments on the manuscript and Rona Levln and Malka Kopelowltz for typing it. This work was supported by grants from the Israel-American Binational Science Foundation, The Israel Cancer Research Fund, the Center for Neurosciences at the Weizmann Institute, and the Minerva and Kekst Foundations (to Y. C.). Y. C. IS the incumbent of the Freedman Career Development Chair.",
year = "1989",
month = nov,
doi = "10.1016/0896-6273(89)90266-3",
language = "English (US)",
volume = "3",
pages = "563--572",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "5",
}