A brain-specific transcription activator

Mira Korner; Amir Rattner; Fabienne Mauxion; Ranjan Sen; Yoav Citri

doi:10.1016/0896-6273(89)90266-3

A brain-specific transcription activator

Mira Korner, Amir Rattner, Fabienne Mauxion, Ranjan Sen, Yoav Citri

Research output: Contribution to journal › Article › peer-review

Abstract

We have identified a DNA binding protein, named BETA, that interacts with the same (B) transcriptional regulatory sequence as the known transcription factor NF-κB. BETA is found only in gray matter throughout the brain, and not in a variety of other rat tissues. Two binding sites for BETA are present adjacent to the promoter of the rat proenkephalin gene. Transfection of primary brain cultures that express BETA, with a reporter gene driven by the SV40 promoter linked to BETA DNA binding sites, results in transcriptional activation. We infer that that BETA is a brain-specific transcription activator.

Original language	English (US)
Pages (from-to)	563-572
Number of pages	10
Journal	Neuron
Volume	3
Issue number	5
DOIs	https://doi.org/10.1016/0896-6273(89)90266-3
State	Published - Nov 1989
Externally published	Yes

ASJC Scopus subject areas

Neuroscience(all)

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abstract = "We have identified a DNA binding protein, named BETA, that interacts with the same (B) transcriptional regulatory sequence as the known transcription factor NF-κB. BETA is found only in gray matter throughout the brain, and not in a variety of other rat tissues. Two binding sites for BETA are present adjacent to the promoter of the rat proenkephalin gene. Transfection of primary brain cultures that express BETA, with a reporter gene driven by the SV40 promoter linked to BETA DNA binding sites, results in transcriptional activation. We infer that that BETA is a brain-specific transcription activator.",

author = "Mira Korner and Amir Rattner and Fabienne Mauxion and Ranjan Sen and Yoav Citri",

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AU - Mauxion, Fabienne

AU - Sen, Ranjan

AU - Citri, Yoav

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N2 - We have identified a DNA binding protein, named BETA, that interacts with the same (B) transcriptional regulatory sequence as the known transcription factor NF-κB. BETA is found only in gray matter throughout the brain, and not in a variety of other rat tissues. Two binding sites for BETA are present adjacent to the promoter of the rat proenkephalin gene. Transfection of primary brain cultures that express BETA, with a reporter gene driven by the SV40 promoter linked to BETA DNA binding sites, results in transcriptional activation. We infer that that BETA is a brain-specific transcription activator.

AB - We have identified a DNA binding protein, named BETA, that interacts with the same (B) transcriptional regulatory sequence as the known transcription factor NF-κB. BETA is found only in gray matter throughout the brain, and not in a variety of other rat tissues. Two binding sites for BETA are present adjacent to the promoter of the rat proenkephalin gene. Transfection of primary brain cultures that express BETA, with a reporter gene driven by the SV40 promoter linked to BETA DNA binding sites, results in transcriptional activation. We infer that that BETA is a brain-specific transcription activator.

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