A blinded, crossover study of the efficacy of the ketogenic diet

John M. Freeman, Eileen P.G. Vining, Eric H Kossoff, Paula L. Pyzik, Xiaobu Ye, Steven N. Goodman

Research output: Contribution to journalArticle

Abstract

Despite over 80 years of use, the ketogenic diet (KD) has never been tested in a blinded manner. Twenty children with intractable Lennox-Gastaut syndrome (LGS) were fasted 36 h and then randomized to receive the classic KD in conjunction with a solution containing either 60 g/day of glucose or saccharin. Parents and physicians were blinded to both the solution composition and level of ketosis. A crossover to the KD with the alternate solution occurred following the sixth day and a repeat fast. A 24-h electroencephalography (EEG) was obtained at baseline and after each arm. After administration of the solution, there was moderate evidence of a reduction in parent-reported seizures between the glucose and saccharin arms, with a median difference of 1.5 seizures per day (p = 0.07). There was no reduction in the number of EEG-identified events, with a median reduction of 7 events per day (p = 0.33). Ketosis was not completely eliminated in the glucose-added arm.

Original languageEnglish (US)
Pages (from-to)322-325
Number of pages4
JournalEpilepsia
Volume50
Issue number2
DOIs
StatePublished - Feb 2009

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Ketogenic Diet
Cross-Over Studies
Saccharin
Ketosis
Glucose
Electroencephalography
Seizures
Parents
Physicians

Keywords

  • Children
  • Epilepsy
  • Fasting
  • Ketogenic diet
  • Randomized crossover trial

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

A blinded, crossover study of the efficacy of the ketogenic diet. / Freeman, John M.; Vining, Eileen P.G.; Kossoff, Eric H; Pyzik, Paula L.; Ye, Xiaobu; Goodman, Steven N.

In: Epilepsia, Vol. 50, No. 2, 02.2009, p. 322-325.

Research output: Contribution to journalArticle

Freeman, John M. ; Vining, Eileen P.G. ; Kossoff, Eric H ; Pyzik, Paula L. ; Ye, Xiaobu ; Goodman, Steven N. / A blinded, crossover study of the efficacy of the ketogenic diet. In: Epilepsia. 2009 ; Vol. 50, No. 2. pp. 322-325.
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