A bioreducible linear poly(β-amino ester) for siRNA delivery

Kristen L. Kozielski, Stephany Tzeng, Jordan Green

Research output: Contribution to journalArticle

Abstract

Described here is the synthesis and characterization of a novel, bioreducible linear poly(β-amino ester) designed to condense siRNA into nanoparticles and efficiently release it upon entering the cytoplasm. Delivery of siRNA using this polymer achieved near-complete knockdown of a fluorescent marker gene in primary human glioblastoma cells with no cytotoxicity.

Original languageEnglish (US)
Pages (from-to)5319-5321
Number of pages3
JournalChemical Communications
Volume49
Issue number46
DOIs
StatePublished - Jun 11 2013

Fingerprint

Cytotoxicity
Small Interfering RNA
Esters
Genes
Nanoparticles
Polymers

ASJC Scopus subject areas

  • Catalysis
  • Ceramics and Composites
  • Electronic, Optical and Magnetic Materials
  • Surfaces, Coatings and Films
  • Materials Chemistry
  • Metals and Alloys
  • Chemistry(all)

Cite this

A bioreducible linear poly(β-amino ester) for siRNA delivery. / Kozielski, Kristen L.; Tzeng, Stephany; Green, Jordan.

In: Chemical Communications, Vol. 49, No. 46, 11.06.2013, p. 5319-5321.

Research output: Contribution to journalArticle

@article{302933666d0044b8a5fc7152fcc939e4,
title = "A bioreducible linear poly(β-amino ester) for siRNA delivery",
abstract = "Described here is the synthesis and characterization of a novel, bioreducible linear poly(β-amino ester) designed to condense siRNA into nanoparticles and efficiently release it upon entering the cytoplasm. Delivery of siRNA using this polymer achieved near-complete knockdown of a fluorescent marker gene in primary human glioblastoma cells with no cytotoxicity.",
author = "Kozielski, {Kristen L.} and Stephany Tzeng and Jordan Green",
year = "2013",
month = "6",
day = "11",
doi = "10.1039/c3cc40718g",
language = "English (US)",
volume = "49",
pages = "5319--5321",
journal = "Chemical Communications",
issn = "1359-7345",
publisher = "Royal Society of Chemistry",
number = "46",

}

TY - JOUR

T1 - A bioreducible linear poly(β-amino ester) for siRNA delivery

AU - Kozielski, Kristen L.

AU - Tzeng, Stephany

AU - Green, Jordan

PY - 2013/6/11

Y1 - 2013/6/11

N2 - Described here is the synthesis and characterization of a novel, bioreducible linear poly(β-amino ester) designed to condense siRNA into nanoparticles and efficiently release it upon entering the cytoplasm. Delivery of siRNA using this polymer achieved near-complete knockdown of a fluorescent marker gene in primary human glioblastoma cells with no cytotoxicity.

AB - Described here is the synthesis and characterization of a novel, bioreducible linear poly(β-amino ester) designed to condense siRNA into nanoparticles and efficiently release it upon entering the cytoplasm. Delivery of siRNA using this polymer achieved near-complete knockdown of a fluorescent marker gene in primary human glioblastoma cells with no cytotoxicity.

UR - http://www.scopus.com/inward/record.url?scp=84877789856&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84877789856&partnerID=8YFLogxK

U2 - 10.1039/c3cc40718g

DO - 10.1039/c3cc40718g

M3 - Article

C2 - 23646347

AN - SCOPUS:84877789856

VL - 49

SP - 5319

EP - 5321

JO - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

IS - 46

ER -