A bioreducible linear poly(β-amino ester) for siRNA delivery

Kristen L. Kozielski, Stephany Y. Tzeng, Jordan J. Green

Research output: Contribution to journalArticle

Abstract

Described here is the synthesis and characterization of a novel, bioreducible linear poly(β-amino ester) designed to condense siRNA into nanoparticles and efficiently release it upon entering the cytoplasm. Delivery of siRNA using this polymer achieved near-complete knockdown of a fluorescent marker gene in primary human glioblastoma cells with no cytotoxicity.

Original languageEnglish (US)
Pages (from-to)5319-5321
Number of pages3
JournalChemical Communications
Volume49
Issue number46
DOIs
StatePublished - May 14 2013

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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