A bioorthogonal 68Ga-labelling strategy for rapid in vivo imaging

Helen L. Evans, Quang Dé Nguyen, Laurence Carroll, Maciej Kaliszczak, Frazer J. Twyman, Alan C. Spivey, Eric O. Aboagye

Research output: Contribution to journalArticle

Abstract

Herein, we describe a fast and robust method for achieving 68Ga-labelling of the EGFR-selective monoclonal antibody (mAb) Cetuximab using the bioorthogonal Inverse-electron-Demand Diels-Alder (IeDDA) reaction. The in vivo imaging of EGFR is demonstrated, as well as the translation of the method within a two-step pretargeting strategy. This journal is

Original languageEnglish (US)
Pages (from-to)9557-9560
Number of pages4
JournalChemical Communications
Volume50
Issue number67
DOIs
StatePublished - Aug 28 2014
Externally publishedYes

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Monoclonal antibodies
Labeling
Monoclonal Antibodies
Imaging techniques
Electrons
Cetuximab

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Cite this

Evans, H. L., Nguyen, Q. D., Carroll, L., Kaliszczak, M., Twyman, F. J., Spivey, A. C., & Aboagye, E. O. (2014). A bioorthogonal 68Ga-labelling strategy for rapid in vivo imaging. Chemical Communications, 50(67), 9557-9560. https://doi.org/10.1039/c4cc03903c

A bioorthogonal 68Ga-labelling strategy for rapid in vivo imaging. / Evans, Helen L.; Nguyen, Quang Dé; Carroll, Laurence; Kaliszczak, Maciej; Twyman, Frazer J.; Spivey, Alan C.; Aboagye, Eric O.

In: Chemical Communications, Vol. 50, No. 67, 28.08.2014, p. 9557-9560.

Research output: Contribution to journalArticle

Evans, HL, Nguyen, QD, Carroll, L, Kaliszczak, M, Twyman, FJ, Spivey, AC & Aboagye, EO 2014, 'A bioorthogonal 68Ga-labelling strategy for rapid in vivo imaging', Chemical Communications, vol. 50, no. 67, pp. 9557-9560. https://doi.org/10.1039/c4cc03903c
Evans HL, Nguyen QD, Carroll L, Kaliszczak M, Twyman FJ, Spivey AC et al. A bioorthogonal 68Ga-labelling strategy for rapid in vivo imaging. Chemical Communications. 2014 Aug 28;50(67):9557-9560. https://doi.org/10.1039/c4cc03903c
Evans, Helen L. ; Nguyen, Quang Dé ; Carroll, Laurence ; Kaliszczak, Maciej ; Twyman, Frazer J. ; Spivey, Alan C. ; Aboagye, Eric O. / A bioorthogonal 68Ga-labelling strategy for rapid in vivo imaging. In: Chemical Communications. 2014 ; Vol. 50, No. 67. pp. 9557-9560.
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