A bioorthogonal 68Ga-labelling strategy for rapid in vivo imaging

Helen L. Evans, Quang Dé Nguyen, Laurence Carroll, Maciej Kaliszczak, Frazer J. Twyman, Alan C. Spivey, Eric O. Aboagye

Research output: Contribution to journalArticle


Herein, we describe a fast and robust method for achieving 68Ga-labelling of the EGFR-selective monoclonal antibody (mAb) Cetuximab using the bioorthogonal Inverse-electron-Demand Diels-Alder (IeDDA) reaction. The in vivo imaging of EGFR is demonstrated, as well as the translation of the method within a two-step pretargeting strategy. This journal is

Original languageEnglish (US)
Pages (from-to)9557-9560
Number of pages4
JournalChemical Communications
Issue number67
Publication statusPublished - Aug 28 2014
Externally publishedYes


ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Cite this

Evans, H. L., Nguyen, Q. D., Carroll, L., Kaliszczak, M., Twyman, F. J., Spivey, A. C., & Aboagye, E. O. (2014). A bioorthogonal 68Ga-labelling strategy for rapid in vivo imaging. Chemical Communications, 50(67), 9557-9560. https://doi.org/10.1039/c4cc03903c