A biomechanical model of soft tissue deformation, with applications to non-rigid registration of brain images with tumor pathology

Stelios K. Kyriacou, Christos Davatzikos

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The finite element method is applied to the biomechanics of brain tissue deformation. Emphasis is given to the deformations induced by the growth of tumors, and to the deformable registration of anatomical atlases with patient images. A uniform contraction of the tumor is first used to obtain an estimate of the shape of the brain prior to the growth of the tumor. A subsequent nonlinear regression method is used to improve on the above estimate. The resulting deformation mapping is finally applied to an atlas, yielding the registration of the atlas with the tumor-deformed anatomy. A preliminary 2D implementation that includes inhomogeneity and a nonlinear elastic material model is tested on simulated data as well as a patient image. The long-term scope of this work is its application to surgical planning systems.

Original languageEnglish (US)
Title of host publicationMedical Image Computing and Computer-Assisted Intervention ─ MICCAI 1998 - 1st International Conference, Proceedings
EditorsWilliam M. Wells, Alan Colchester, Scott Delp
PublisherSpringer Verlag
Pages531-538
Number of pages8
ISBN (Print)3540651365, 9783540651369
DOIs
StatePublished - 1998
Event1st International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 1998 - Cambridge, United States
Duration: Oct 11 1998Oct 13 1998

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume1496
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Other

Other1st International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 1998
CountryUnited States
CityCambridge
Period10/11/9810/13/98

Keywords

  • Biomechanics
  • Brain atlas
  • Inverse methods
  • Registration

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)

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  • Cite this

    Kyriacou, S. K., & Davatzikos, C. (1998). A biomechanical model of soft tissue deformation, with applications to non-rigid registration of brain images with tumor pathology. In W. M. Wells, A. Colchester, & S. Delp (Eds.), Medical Image Computing and Computer-Assisted Intervention ─ MICCAI 1998 - 1st International Conference, Proceedings (pp. 531-538). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 1496). Springer Verlag. https://doi.org/10.1007/bfb0056238