A biomechanical model of soft tissue deformation, with applications to non-rigid registration of brain images with tumor pathology

Stelios K. Kyriacou, Christos Davatzikos

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The finite element method is applied to the biomechanics of brain tissue deformation. Emphasis is given to the deformations induced by the growth of tumors, and to the deformable registration of anatomical atlases with patient images. A uniform contraction of the tumor is first used to obtain an estimate of the shape of the brain prior to the growth of the tumor. A subsequent nonlinear regression method is used to improve on the above estimate. The resulting deformation mapping is finally applied to an atlas, yielding the registration of the atlas with the tumor-deformed anatomy. A preliminary 2D implementation that includes inhomogeneity and a nonlinear elastic material model is tested on simulated data as well as a patient image. The long-term scope of this work is its application to surgical planning systems.

Original languageEnglish (US)
Title of host publicationLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
PublisherSpringer Verlag
Pages531-538
Number of pages8
Volume1496
ISBN (Print)3540651365, 9783540651369
StatePublished - 1998
Event1st International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 1998 - Cambridge, United States
Duration: Oct 11 1998Oct 13 1998

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume1496
ISSN (Print)03029743
ISSN (Electronic)16113349

Other

Other1st International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 1998
CountryUnited States
CityCambridge
Period10/11/9810/13/98

Fingerprint

Non-rigid Registration
Soft Tissue
Pathology
Tumors
Tumor
Atlas
Brain
Tissue
Registration
Biomechanics
Nonlinear Regression
Elastic Material
Anatomy
Inhomogeneity
Model
Estimate
Contraction
Finite Element Method
Planning
Finite element method

Keywords

  • Biomechanics
  • Brain atlas
  • Inverse methods
  • Registration

ASJC Scopus subject areas

  • Computer Science(all)
  • Theoretical Computer Science

Cite this

Kyriacou, S. K., & Davatzikos, C. (1998). A biomechanical model of soft tissue deformation, with applications to non-rigid registration of brain images with tumor pathology. In Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) (Vol. 1496, pp. 531-538). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 1496). Springer Verlag.

A biomechanical model of soft tissue deformation, with applications to non-rigid registration of brain images with tumor pathology. / Kyriacou, Stelios K.; Davatzikos, Christos.

Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). Vol. 1496 Springer Verlag, 1998. p. 531-538 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 1496).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Kyriacou, SK & Davatzikos, C 1998, A biomechanical model of soft tissue deformation, with applications to non-rigid registration of brain images with tumor pathology. in Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). vol. 1496, Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), vol. 1496, Springer Verlag, pp. 531-538, 1st International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 1998, Cambridge, United States, 10/11/98.
Kyriacou SK, Davatzikos C. A biomechanical model of soft tissue deformation, with applications to non-rigid registration of brain images with tumor pathology. In Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). Vol. 1496. Springer Verlag. 1998. p. 531-538. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)).
Kyriacou, Stelios K. ; Davatzikos, Christos. / A biomechanical model of soft tissue deformation, with applications to non-rigid registration of brain images with tumor pathology. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). Vol. 1496 Springer Verlag, 1998. pp. 531-538 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)).
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