A biomaterial approach to cell reprogramming and differentiation

Joseph Long, Hyejin Kim, Dajeong Kim, Jong Bum Lee, Deok Ho Kim

Research output: Contribution to journalReview articlepeer-review

Abstract

The cell reprogramming of somatic cells into pluripotent states and subsequent differentiation into certain phenotypes has helped progress regenerative medicine research and other medical applications. Recent research has used viral vectors to induce this reprogramming; however, limitations include low efficiency and safety concerns. In this review, we discuss how biomaterial methods offer potential avenues for either increasing viability and downstream applicability of viral methods, or providing a safer alternative. The use of non-viral delivery systems, such as electroporation, micro/nanoparticles, nucleic acids and the modulation of culture substrate topography and stiffness, has generated valuable insights regarding cell reprogramming.

Original languageEnglish (US)
Pages (from-to)2375-2389
Number of pages15
JournalJournal of Materials Chemistry B
Volume5
Issue number13
DOIs
StatePublished - 2017
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)
  • Biomedical Engineering
  • Materials Science(all)

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