TY - JOUR
T1 - A biodegradable 3D woven magnesium-based scaffold for orthopedic implants
AU - Xue, Ju
AU - Singh, Srujan
AU - Zhou, Yuxiao
AU - Perdomo-Pantoja, Alexander
AU - Tian, Ye
AU - Gupta, Nehali
AU - Witham, Timothy F.
AU - Grayson, Warren L.
AU - Weihs, Timothy P.
N1 - Publisher Copyright:
© 2022 The Author(s). Published by IOP Publishing Ltd.
PY - 2022/7
Y1 - 2022/7
N2 - Porous Magnesium (Mg) is a promising biodegradable scaffold for treating critical-size bone defects, and as an essential element for human metabolism, Mg has shown sufficient biocompatibility. Its elastic moduli and yield strengths are closer to those of cortical bone than common, inert metallic implants, effectively reducing stress concentrations around host tissue as well as stress shielding. More importantly, Mg can degrade and be absorbed in the human body in a safe and controlled manner, thereby reducing the need for second surgeries to remove implants. The development of porous Mg scaffolds via conventional selective laser melting techniques has been limited due to Mg's low boiling point, high vapor pressures, high reactivity, and non-ideal microstructures in additively manufactured parts. Here we present an exciting alternative to conventional additive techniques: 3D weaving with Mg wires that have controlled chemistries and microstructures. The weaving process offers high throughput manufacturing as well as porous architectures that can be optimized for stiffness and porosity with topology optimization. Once woven, we dip-coat the weaves with polylactic acid to enhance their strength and corrosion resistance. Following fabrication, we characterize their mechanical properties, corrosion behavior, and cell compatibility in vitro, and we use an intramuscular implantation model to evaluate their in vivo corrosion behavior and tissue response.
AB - Porous Magnesium (Mg) is a promising biodegradable scaffold for treating critical-size bone defects, and as an essential element for human metabolism, Mg has shown sufficient biocompatibility. Its elastic moduli and yield strengths are closer to those of cortical bone than common, inert metallic implants, effectively reducing stress concentrations around host tissue as well as stress shielding. More importantly, Mg can degrade and be absorbed in the human body in a safe and controlled manner, thereby reducing the need for second surgeries to remove implants. The development of porous Mg scaffolds via conventional selective laser melting techniques has been limited due to Mg's low boiling point, high vapor pressures, high reactivity, and non-ideal microstructures in additively manufactured parts. Here we present an exciting alternative to conventional additive techniques: 3D weaving with Mg wires that have controlled chemistries and microstructures. The weaving process offers high throughput manufacturing as well as porous architectures that can be optimized for stiffness and porosity with topology optimization. Once woven, we dip-coat the weaves with polylactic acid to enhance their strength and corrosion resistance. Following fabrication, we characterize their mechanical properties, corrosion behavior, and cell compatibility in vitro, and we use an intramuscular implantation model to evaluate their in vivo corrosion behavior and tissue response.
KW - 3D weave
KW - biodegradable metal
KW - biomaterial scaffold
KW - magnesium alloy
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U2 - 10.1088/1758-5090/ac73b8
DO - 10.1088/1758-5090/ac73b8
M3 - Article
C2 - 35617927
AN - SCOPUS:85131902472
SN - 1758-5082
VL - 14
JO - Biofabrication
JF - Biofabrication
IS - 3
M1 - 034107
ER -