Platelets are cell fragments lacking nuclei that play a key role in blood clotting. Using an impressive genetic screen involving ENU-mutagenesis of whole mice, Mason et al. (2007) report in this issue their identification of mutations in the antiapoptotic protein Bcl-xL that cause accelerated death of platelets leading to platelet deficiency.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)