Abstract
Interaction of the conserved CCA terminus of tRNA with rRNA in the peptidyl transferase P site has been studied by in vitro genetics. A Watson—Crick G—C pair between G2252 in a conserved hairpin loop of 23S rRNA and C74 at the acceptor end of tRNA is required for proper functional interaction of the CCA end of tRNA with the ribosomal P site. These findings establish a direct role for 23S rRNA in protein synthesis.
Original language | English (US) |
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Pages (from-to) | 309-314 |
Number of pages | 6 |
Journal | Nature |
Volume | 377 |
Issue number | 6547 |
DOIs | |
State | Published - Sep 28 1995 |
Externally published | Yes |
ASJC Scopus subject areas
- General