A base pair between tRNA and 23S rRNA in the peptidyl transferase centre of the ribosome

Raymond R. Samaha, Rachel Green, Harry F. Noller

Research output: Contribution to journalArticle

Abstract

Interaction of the conserved CCA terminus of tRNA with rRNA in the peptidyl transferase P site has been studied by in vitro genetics. A Watson—Crick G—C pair between G2252 in a conserved hairpin loop of 23S rRNA and C74 at the acceptor end of tRNA is required for proper functional interaction of the CCA end of tRNA with the ribosomal P site. These findings establish a direct role for 23S rRNA in protein synthesis.

Original languageEnglish (US)
Pages (from-to)309-314
Number of pages6
JournalNature
Volume377
Issue number6547
DOIs
StatePublished - Sep 28 1995
Externally publishedYes

ASJC Scopus subject areas

  • General

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