A bacterial protein enhances the release and efficacy of liposomal cancer drugs

Ian Cheong, Xin Huang, Chetan Bettegowda, Luis A. Diaz, Kenneth W Kinzler, Shibin Zhou, Bert Vogelstein

Research output: Contribution to journalArticle

Abstract

Clostridium novyi-NT is an anaerobic bacterium that can infect hypoxic regions within experimental tumors. Because C. novyi-NT lyses red blood cells, we hypothesized that its membrane-disrupting properties could be exploited to enhance the release of liposome-encapsulated drugs within tumors. Here, we show that treatment of mice bearing large, established tumors with C. novyi-NT plus a single dose of liposomal doxorubicin often led to eradication of the tumors. The bacterial factor responsible for the enhanced drug release was identified as a previously unrecognized protein termed liposomase. This protein could potentially be incorporated into diverse experimental approaches for the specific delivery of chemotherapeutic agents to tumors.

Original languageEnglish (US)
Pages (from-to)1308-1311
Number of pages4
JournalScience
Volume314
Issue number5803
DOIs
StatePublished - Nov 24 2006

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