A 4-year study of the epidemiology of Vibrio cholerae in four rural areas of Bangladesh

R. Bradley Sack; A. Kasem Siddique; Ira M. Longini; Azhar Nizam; Md Yunus; M. Sirajul Islam; J. Glenn Morris; Afsar Ali; Anwar Huq; G. Balakrish Nair; Firdausi Qadri; Shah M. Faruque; David A. Sack; Rita R. Colwell

doi:10.1086/345865

A 4-year study of the epidemiology of Vibrio cholerae in four rural areas of Bangladesh

R. Bradley Sack, A. Kasem Siddique, Ira M. Longini, Azhar Nizam, Md Yunus, M. Sirajul Islam, J. Glenn Morris, Afsar Ali, Anwar Huq, G. Balakrish Nair, Firdausi Qadri, Shah M. Faruque, David A. Sack, Rita R. Colwell

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

119 Scopus citations

Abstract

How Vibrio cholerae spreads around the world and what determines its seasonal peaks in endemic areas are not known. These features of cholera have been hypothesized to be primarily the result of environmental factors associated with aquatic habitats that can now be identified. Since 1997, fortnightly surveillance in 4 widely separated geographic locations in Bangladesh has been performed to identify patients with cholera and to collect environmental data. A total of 5670 patients (53% <5 years of age) have been studied; 14.3% had cholera (10.4% due to V. cholerae O1 El Tor, 3.8% due to O139). Both serogroups were found in all locations; outbreaks were seasonal and often occurred simultaneously. Water-use patterns showed that bathing and washing clothes in tube-well water was significantly protective in two of the sites. These data will be correlated with environmental factors, to develop a model for prediction of cholera outbreaks.

Original language	English (US)
Pages (from-to)	96-101
Number of pages	6
Journal	Journal of Infectious Diseases
Volume	187
Issue number	1
DOIs	https://doi.org/10.1086/345865
State	Published - Jan 1 2003

ASJC Scopus subject areas

Immunology and Allergy
Infectious Diseases

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title = "A 4-year study of the epidemiology of Vibrio cholerae in four rural areas of Bangladesh",

abstract = "How Vibrio cholerae spreads around the world and what determines its seasonal peaks in endemic areas are not known. These features of cholera have been hypothesized to be primarily the result of environmental factors associated with aquatic habitats that can now be identified. Since 1997, fortnightly surveillance in 4 widely separated geographic locations in Bangladesh has been performed to identify patients with cholera and to collect environmental data. A total of 5670 patients (53% <5 years of age) have been studied; 14.3% had cholera (10.4% due to V. cholerae O1 El Tor, 3.8% due to O139). Both serogroups were found in all locations; outbreaks were seasonal and often occurred simultaneously. Water-use patterns showed that bathing and washing clothes in tube-well water was significantly protective in two of the sites. These data will be correlated with environmental factors, to develop a model for prediction of cholera outbreaks.",

author = "Sack, {R. Bradley} and Siddique, {A. Kasem} and Longini, {Ira M.} and Azhar Nizam and Md Yunus and Islam, {M. Sirajul} and Morris, {J. Glenn} and Afsar Ali and Anwar Huq and Nair, {G. Balakrish} and Firdausi Qadri and Faruque, {Shah M.} and Sack, {David A.} and Colwell, {Rita R.}",

note = "Funding Information: Financial support: National Institutes of Health (grant AI39129.01-05). Funding Information: This work was supported by the International Centre for Diarrheal Disease Research, Bangladesh (ICDDR,B). The ICDDR,B is supported by countries and agencies that share its concern for health problems of developing countries. We would like to thank the physicians and staff at the ICDDR,B for their dedicated work in supporting this project.",

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AU - Sack, R. Bradley

AU - Siddique, A. Kasem

AU - Longini, Ira M.

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AU - Yunus, Md

AU - Islam, M. Sirajul

AU - Morris, J. Glenn

AU - Ali, Afsar

AU - Huq, Anwar

AU - Nair, G. Balakrish

AU - Qadri, Firdausi

AU - Faruque, Shah M.

AU - Sack, David A.

AU - Colwell, Rita R.

N1 - Funding Information: Financial support: National Institutes of Health (grant AI39129.01-05). Funding Information: This work was supported by the International Centre for Diarrheal Disease Research, Bangladesh (ICDDR,B). The ICDDR,B is supported by countries and agencies that share its concern for health problems of developing countries. We would like to thank the physicians and staff at the ICDDR,B for their dedicated work in supporting this project.

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A 4-year study of the epidemiology of Vibrio cholerae in four rural areas of Bangladesh

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