@article{59ecb848b8974e7794ac3c73b8e0f610,
title = "A 12-Month-Interval Dosing Study in Adults Indicates That a Single Dose of the National Institute of Allergy and Infectious Diseases Tetravalent Dengue Vaccine Induces a Robust Neutralizing Antibody Response",
abstract = "The ideal dengue vaccine will provide protection against all serotypes of dengue virus and will be economical and uncomplicated in its administration. To determine the ability of a single dose of the live attenuated tetravalent dengue vaccine TV003 to induce a suitable neutralizing antibody response, a placebo-controlled clinical trial was performed in 48 healthy adults who received 2 doses of vaccine or placebo administered 12 months apart. Evaluation of safety, vaccine viremia, and neutralizing antibody response after each dose indicated that the first dose of vaccine was capable of preventing infection with the second dose, thus indicating that multiple doses are unnecessary.",
keywords = "clinicaltrial, dengue vaccine, live attenuated tetravalent",
author = "Durbin, {Anna P.} and Kirkpatrick, {Beth D.} and Pierce, {Kristen K.} and Carmolli, {Marya P.} and Tibery, {Cecilia M.} and Grier, {Palmtama L.} and Noreen Hynes and Kari Opert and Jarvis, {Adrienne P.} and Sabundayo, {Beulah P.} and McElvany, {Benjamin D.} and Sendra, {Eli A.} and Larsson, {Catherine J.} and Matthew Jo and Lovchik, {Janece M.} and Luke, {Catherine J.} and Walsh, {Mary C.} and Fraser, {Ellen A.} and Kanta Subbarao and Whitehead, {Stephen S.}",
note = "Funding Information: The work was supported by the National Institute of Allergy and Infectious Diseases Intramural Research Program, National Institutes of Health (contract HHSN272200900010C). Publisher Copyright: {\textcopyright} 2016 Published by Oxford University Press for the Infectious Diseases Society of America.",
year = "2016",
month = sep,
day = "15",
doi = "10.1093/infdis/jiw067",
language = "English (US)",
volume = "214",
pages = "832--835",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "6",
}