A 10-Year immunopersistence study of hepatitis E antibodies in rural bangladesh

Brittany L. Kmush, Khalequ Zaman, Mohammed Yunus, Parimalendu Saha, Kenrad E. Nelson, Alain B. Labrique

Research output: Contribution to journalArticlepeer-review

Abstract

Hepatitis E virus (HEV) is a major cause of acute viral hepatitis in Southeast Asia. Several studies have suggested that antibody persistence after HEV infection may be transient, possibly increasing the risk of reinfection and contributing to the frequency of outbreaks in HEV-endemic regions. The specific conditions under which antibodies to HEV are lost, or “seroreversion” occurs, are poorly understood. Here, 100 participants from population-based studies in rural Bangladesh were revisited in 2015, 10 years after a documented HEV infection, to examine long-term antibody persistence. Twenty percent (95% confidence interval: 12.0, 28.0) of the participants no longer had detectable antibodies at follow-up, suggesting that antibodies generally persist for at least a decade after infection in rural Bangladesh. Persons who were seronegative at follow-up were generally younger at infection than those who remained positive (14.4 years vs. 33.6 years; P < 0.0001). This age-dependent antibody loss could partially explain cross-sectional seroprevalence data from Southeast Asia, where children have reportedly low antibody prevalence. The results of this study provide new insight into the immunological persistence of HEV infection in a micronutrient-deficient rural population of South Asia, highlighting the importance of age at infection in the ability to produce long-lasting antibodies against HEV.

Original languageEnglish (US)
Pages (from-to)1501-1510
Number of pages10
JournalAmerican journal of epidemiology
Volume187
Issue number7
DOIs
StatePublished - 2018
Externally publishedYes

Keywords

  • Antibodies
  • Antibody persistence
  • Hepatitis E virus
  • Seroepidemiologic studies

ASJC Scopus subject areas

  • Epidemiology

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