A 10-year experience with topical mechlorethamine for mycosis fungoides: Comparison with patients treated by total-skin electron-beam radiation therapy

E. C. Vonderheid, E. J. Van Scott, P. E. Wallner, W. C. Johnson

Research output: Contribution to journalArticlepeer-review

Abstract

A group of 243 patients with mycosis fungoides (MF) received treatment with topical applications of dilute acqueous solutions of mechlorethamine and/or systemic chemotherapy over the past 10 years. The likelihood of a complete and relapse-free remission and survival was found to correlate inversely to the magnitude of disease as denoted by a simple staging system. Although disease-free intervals of > 3 years have occurred thus far in 32 (13%) patients, the permanency of these remissions and the curability of disease remain uncertain because of the variability of disease progression characteristic of MF. Comparison of treatment results with those published on a large group of patients treated with total-skin electron-beam radiation therapy indicates that the chemotherapeutic approach to the treatment of MF is equally effective in promoting survival.

Original languageEnglish (US)
Pages (from-to)681-689
Number of pages9
JournalCancer Treatment Reports
Volume63
Issue number4
StatePublished - 1979
Externally publishedYes

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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