A γδ+ T-cell leukemia bearing a novel t(8;14)(q24;q11) translocation demonstrates spontaneous in vitro natural killer-like activity

R. T. Maziarz, R. J. Arceci, S. C. Bernstein, L. Frazier, B. R. Smith, M. Kasai, R. Tantravahi, J. L. Strominger

Research output: Contribution to journalArticle

Abstract

A highly malignant human T-cell leukemia was identified by cell surface analysis as a member of the T-cell receptor (TCR) γδ lineage. Cytogenetic and molecular analysis showed a novel t(8;14)(q24;q11) rearrangement involving the J(δ1) gene segment on chromosome 14 and the distal end of chromosome 8 near the c-myc proto-oncogene locus. The γδ TCR of the leukemia blasts was functionally intact and could be activated to generate intracellular calcium flux and to target Fc receptor-mediated redirected tumor cell lysis. In addition, non-major histocompatibility complex restricted lysis of a limited target cell panel was shown by fresh leukemic blasts and by the in vitro-maintained leukemia cells that was comparable to known T-cell lines with natural killer-like activity. These data suggest that the T-cell leukemia potentially had in vivo functional cytolytic activity. However, whether this activity did contribute to the patient's clinical condition could not be determined.

Original languageEnglish (US)
Pages (from-to)1523-1531
Number of pages9
JournalBlood
Volume79
Issue number6
DOIs
StatePublished - 1992

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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    Maziarz, R. T., Arceci, R. J., Bernstein, S. C., Frazier, L., Smith, B. R., Kasai, M., Tantravahi, R., & Strominger, J. L. (1992). A γδ+ T-cell leukemia bearing a novel t(8;14)(q24;q11) translocation demonstrates spontaneous in vitro natural killer-like activity. Blood, 79(6), 1523-1531. https://doi.org/10.1182/blood.v79.6.1523.1523