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  • Charles G Eberhart
2020

An Update on Endocrine Mucin-producing Sweat Gland Carcinoma: Clinicopathologic Study of 63 Cases and Comparative Analysis

Agni, M., Raven, M. L., Bowen, R. C., Laver, N. V., Chevez-Barrios, P., Milman, T., Eberhart, C. G., Couch, S., Bennett, D. D., Albert, D. M., Hogan, R. N., Phelps, P. O., Stiefel, H., Mancera, N., Hyrcza, M., Wang, A., Steele, E. A., Campbell, A. A., Potter, H. D. & Lucarelli, M. J., Jan 1 2020, (Accepted/In press) In : American Journal of Surgical Pathology.

Research output: Contribution to journalArticle

Astrocytes: new stars in the medulloblastoma firmament

Eberhart, C., May 15 2020, In : Neuro-oncology. 22, 5, p. 587-589 3 p.

Research output: Contribution to journalArticle

Astrocytic trans-Differentiation Completes a Multicellular Paracrine Feedback Loop Required for Medulloblastoma Tumor Growth

Yao, M., Ventura, P. B., Jiang, Y., Rodriguez, F. J., Wang, L., Perry, J. S. A., Yang, Y., Wahl, K., Crittenden, R. B., Bennett, M. L., Qi, L., Gong, C. C., Li, X. N., Barres, B. A., Bender, T. P., Ravichandran, K. S., Janes, K. A., Eberhart, C. G. & Zong, H., Feb 6 2020, In : Cell. 180, 3, p. 502-520.e19

Research output: Contribution to journalArticle

Increased tau expression correlates with IDH mutation in infiltrating gliomas and impairs cell migration

Nakata, S., Price, A., Eberhart, C. & Morris, M., May 1 2020, In : Journal of neuropathology and experimental neurology. 79, 5, p. 493-499 7 p.

Research output: Contribution to journalArticle

Invasive squamous cell carcinomas and precursor lesions on UV-exposed epithelia demonstrate concordant genomic complexity in driver genes

Lazo de la Vega, L., Bick, N., Hu, K., Rahrig, S. E., Silva, C. D., Matayoshi, S., Picciarelli, P., Wang, X., Sugar, A., Soong, H. K., Mian, S. I., Robinson, D. R., Chinnaiyan, A. M., Demirci, H., Daniels, A. B., Worden, F., Eberhart, C. G., Tomlins, S. A., Rao, R. C. & Harms, P. W., Jan 1 2020, (Accepted/In press) In : Modern Pathology.

Research output: Contribution to journalArticle

Non-adhesive and highly stable biodegradable nanoparticles that provide widespread and safe transgene expression in orthotopic brain tumors

Negron, K., Zhu, C., Chen, S. W., Shahab, S., Rao, D., Raabe, E. H., Eberhart, C. G., Hanes, J. & Suk, J. S., Jun 1 2020, In : Drug Delivery and Translational Research. 10, 3, p. 572-581 10 p.

Research output: Contribution to journalArticle

Orbital solitary fibrous tumors: a multi-centered histopathological and immunohistochemical analysis with radiological description

Alkatan, H. M., Alsalamah, A. K., Almizel, A., Alshomar, K. M., Maktabi, A. M., ElKhamary, S. M., Eberhart, C. G., Iuliano, A., Lanni, V. & Strianese, D., May 1 2020, In : Annals of Saudi medicine. 40, 3, p. 227-233 7 p.

Research output: Contribution to journalArticle

Open Access

PD-L1 expression in pediatric low-grade gliomas is independent of BRAF V600E mutational status

Martin, A. M., Bell, W. R., Yuan, M., Harris, L., Poore, B., Arnold, A., Engle, E. L., Asnaghi, L., Lim, M., Raabe, E. H. & Eberhart, C. G., Jan 1 2020, In : Journal of neuropathology and experimental neurology. 79, 1, p. 74-85 12 p.

Research output: Contribution to journalArticle

Phase II Study of Nonmetastatic Desmoplastic Medulloblastoma in Children Younger Than 4 Years of Age: A Report of the Children's Oncology Group (ACNS1221)

Lafay-Cousin, L., Bouffet, E., Strother, D., Rudneva, V., Hawkins, C., Eberhart, C., Horbinski, C., Heier, L., Souweidane, M., Williams-Hughes, C., Onar-Thomas, A., Billups, C. A., Fouladi, M., Northcott, P., Robinson, G. & Gajjar, A., Jan 20 2020, In : Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 38, 3, p. 223-231 9 p.

Research output: Contribution to journalArticle

Open Access

Spatial enrichment of cellular states in glioblastoma

Eberhart, C. G. & Bar, E. E., Jul 1 2020, In : Acta neuropathologica. 140, 1, p. 85-87 3 p.

Research output: Contribution to journalLetter

SWI/SNF complex differences promote cellular heterogeneity in rhabdoid tumors

Eberhart, C. G. & Rubens, J. A., Jun 9 2020, In : Neuro-oncology. 22, 6, p. 741-742 2 p.

Research output: Contribution to journalEditorial

Synergistic activity of mTORC1/2 kinase and MEK inhibitors suppresses pediatric low-grade glioma tumorigenicity and vascularity

Arnold, A., Yuan, M., Price, A., Harris, L., Eberhart, C. G. & Raabe, E., Apr 15 2020, In : Neuro-oncology. 22, 4, p. 563-574 12 p.

Research output: Contribution to journalArticle

2019

ADAM3A copy number gains occur in a subset of conjunctival squamous cell carcinoma and its high grade precursors

Vizcaino, M. A., Tabbarah, A. Z., Asnaghi, L., Maktabi, A., Eghrari, A. O., Srikumaran, D., Eberhart, C. G. & Rodriguez, F. J., Dec 2019, In : Human pathology. 94, p. 92-97 6 p.

Research output: Contribution to journalArticle

A fox with many faces: FOXR2 and embryonal brain tumors

Eberhart, C. G., Aug 1 2019, In : Neuro-oncology. 21, 8, p. 963-964 2 p.

Research output: Contribution to journalEditorial

Association of Giant Cell Arteritis with Race

Gruener, A. M., Poostchi, A., Carey, A. R., Eberhart, C. G., Henderson, A. D., Chang, J. R. & McCulley, T. J., Oct 2019, In : JAMA ophthalmology. 137, 10, p. 1175-1179 5 p.

Research output: Contribution to journalArticle

ATRX Mutations in Pineal Parenchymal Tumors of Intermediate Differentiation

Martínez, H., Nagurney, M., Wang, Z. X., Eberhart, C. G., Heaphy, C. M., Curtis, M. T. & Rodriguez, F. J., Jan 1 2019, In : Journal of neuropathology and experimental neurology. 78, 8, p. 703-708 6 p.

Research output: Contribution to journalArticle

Open Access

A unique telomere DNA expansion phenotype in human retinal rod photoreceptors associated with aging and disease

Bell, W. R., Meeker, A. K., Rizzo, A., Rajpara, S., Rosenthal, I. M., Flores Bellver, M., Aparicio Domingo, S., Zhong, X., Barber, J. R., Joshu, C. E., Canto-Soler, M. V., Eberhart, C. G. & Heaphy, C. M., Jan 2019, In : Brain Pathology. 29, 1, p. 45-52 8 p.

Research output: Contribution to journalArticle

Controlled release of corticosteroid with biodegradable nanoparticles for treating experimental autoimmune uveitis

Luo, L., Yang, J., Oh, Y., Hartsock, M. J., Xia, S., Kim, Y. C., Ding, Z., Meng, T., Eberhart, C. G., Ensign, L. M., Thorne, J. E., Stark, W. J., Duh, E. J., Xu, Q. & Hanes, J., Feb 28 2019, In : Journal of Controlled Release. 296, p. 68-80 13 p.

Research output: Contribution to journalArticle

Controlled release of dexamethasone sodium phosphate with biodegradable nanoparticles for preventing experimental corneal neovascularization

Wang, B., Tang, Y., Oh, Y., Lamb, N. W., Xia, S., Ding, Z., Chen, B., Suarez, M. J., Meng, T., Kulkarni, V., Eberhart, C. G., Ensign, L. M., Stark, W. J., Hanes, J. & Xu, Q., Apr 2019, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 17, p. 119-123 5 p.

Research output: Contribution to journalArticle

Downregulation of Nodal inhibits metastatic progression in retinoblastoma

Asnaghi, L., White, D. T., Yoon, L., Price, A., Lee, G. Y., Sahoo, A., Mumm, J. & Eberhart, C. G., Aug 26 2019, In : Acta Neuropathologica Communications. 7, 1, 1 p.

Research output: Contribution to journalArticle

Open Access

Genomic Landscape of Intramedullary Spinal Cord Gliomas

Zhang, M., Iyer, R. R., Azad, T. D., Wang, Q., Garzon-Muvdi, T., Wang, J., Liu, A., Burger, P., Eberhart, C., Rodriguez, F. J., Sciubba, D. M., Wolinsky, J. P., Gokaslan, Z., Groves, M. L., Jallo, G. I. & Bettegowda, C., Dec 1 2019, In : Scientific reports. 9, 1, 18722.

Research output: Contribution to journalArticle

Open Access

Immunohistochemical characterization of procaspase-3 overexpression as a druggable target with PAC-1, a procaspase-3 activator, in canine and human brain cancers

Schlein, L. J., Fadl-Alla, B., Pondenis, H. C., Lezmi, S., Eberhart, C. G., LeBlanc, A. K., Dickinson, P. J., Hergenrother, P. J. & Fan, T. M., Jan 1 2019, In : Frontiers in Oncology. 9, FEB, 96.

Research output: Contribution to journalArticle

Open Access
Open Access

Inhibition of enhancer of zest homologue 2 is a potential therapeutic target for high-MYC medulloblastoma

Natsumeda, M., Liu, Y., Nakata, S., Miyahara, H., Hanaford, A., Ahsan, S., Stearns, D., Skuli, N., Kahlert, U. D., Raabe, E. H., Rodriguez, F. J. & Eberhart, C. G., Apr 2019, In : Neuropathology. 39, 2, p. 71-77 7 p.

Research output: Contribution to journalArticle

Inhibition of mTORC1 in pediatric low-grade glioma depletes glutathione and therapeutically synergizes with carboplatin

Poore, B., Yuan, M., Arnold, A., Price, A., Alt, J., Rubens, J., Slusher, B., Eberhart, C. G. & Raabe, E., Feb 14 2019, In : Neuro-oncology. 21, 2, p. 252-263 12 p.

Research output: Contribution to journalArticle

Mapping Keratoconus Molecular Substrates by Multiplexed High-Resolution Proteomics of Unpooled Corneas

Shinde, V., Hu, N., Renuse, S., Mahale, A., Pandey, A., Eberhart, C., Stone, D., Al-Swailem, S. A., Maktabi, A. & Chakravarti, S., Nov 2019, In : OMICS A Journal of Integrative Biology. 23, 11, p. 583-597 15 p.

Research output: Contribution to journalArticle

Multi-layered core-sheath fiber membranes for controlled drug release in the local treatment of brain tumor

Han, D., Serra, R., Gorelick, N., Fatima, U., Eberhart, C. G., Brem, H., Tyler, B. & Steckl, A. J., Dec 1 2019, In : Scientific reports. 9, 1, 17936.

Research output: Contribution to journalArticle

Open Access

Mycand loss of p53 cooperate to drive formation of choroid plexus carcinoma

Wang, J., Merino, D. M., Light, N., Murphy, B. L., Wang, Y. D., Guo, X., Hodges, A. P., Chau, L. Q., Liu, K. W., Dhall, G., Asgharzadeh, S., Kiehna, E. N., Shirey, R. J., Janda, K. D., Taylor, M. D., Malkin, D., Ellison, D. W., VandenBerg, S. R., Eberhart, C. G., Sears, R. C. & 3 others, Rousse, M. F., Gilbertson, R. J. & Wechsler-Reya, R. J., Jan 1 2019, In : Cancer Research. 79, 9, p. 2208-2219 12 p.

Research output: Contribution to journalArticle

MYC drives group 3 medulloblastoma through transformation of Sox2 þ astrocyte progenitor cells

Tao, R., Murad, N., Xu, Z., Zhang, P., Okonechnikov, K., Kool, M., Rivero-Hinojosa, S., Lazarski, C., Zheng, P., Liu, Y., Eberhart, C. G., Rood, B. R., Packer, R. & Pei, Y., Apr 15 2019, In : Cancer Research. 79, 8, p. 1967-1980 14 p.

Research output: Contribution to journalArticle

Orally bioavailable glutamine antagonist prodrug JHU-083 penetrates mouse brain and suppresses the growth of MYC-driven medulloblastoma

Hanaford, A. R., Alt, J., Rais, R., Wang, S. Z., Kaur, H., Thorek, D. L. J., Eberhart, C. G., Slusher, B., Martin, A. & Raabe, E., Oct 1 2019, In : Translational Oncology. 12, 10, p. 1314-1322 9 p.

Research output: Contribution to journalArticle

Open Access

Periocular Histiocytoid Carcinoma: Potential Diagnostic Challenges

Yates, J. R., Mines, M. J., Subramanian, P. S., Rivera-Michlig, R., Cummings, T. J. & Eberhart, C. G., Feb 1 2019, In : Ocular Oncology and Pathology. 5, 2, p. 94-101 8 p.

Research output: Contribution to journalArticle

Recurrent noncoding U1 snRNA mutations drive cryptic splicing in SHH medulloblastoma

Suzuki, H., Kumar, S. A., Shuai, S., Diaz-Navarro, A., Gutierrez-Fernandez, A., De Antonellis, P., Cavalli, F. M. G., Juraschka, K., Farooq, H., Shibahara, I., Vladoiu, M. C., Zhang, J., Abeysundara, N., Przelicki, D., Skowron, P., Gauer, N., Luu, B., Daniels, C., Wu, X., Forget, A. & 48 others, Momin, A., Wang, J., Dong, W., Kim, S. K., Grajkowska, W. A., Jouvet, A., Fèvre-Montange, M., Garrè, M. L., Nageswara Rao, A. A., Giannini, C., Kros, J. M., French, P. J., Jabado, N., Ng, H. K., Poon, W. S., Eberhart, C. G., Pollack, I. F., Olson, J. M., Weiss, W. A., Kumabe, T., López-Aguilar, E., Lach, B., Massimino, M., Van Meir, E. G., Rubin, J. B., Vibhakar, R., Chambless, L. B., Kijima, N., Klekner, A., Bognár, L., Chan, J. A., Faria, C. C., Ragoussis, J., Pfister, S. M., Goldenberg, A., Wechsler-Reya, R. J., Bailey, S. D., Garzia, L., Morrissy, A. S., Marra, M. A., Huang, X., Malkin, D., Ayrault, O., Ramaswamy, V., Puente, X. S., Calarco, J. A., Stein, L. & Taylor, M. D., Oct 31 2019, In : Nature. 574, 7780, p. 707-711 5 p.

Research output: Contribution to journalArticle

Sleeping beauty insertional mutagenesis reveals important genetic drivers of central nervous system embryonal tumors

Beckmann, P. J., Larson, J. D., Larsson, A. T., Ostergaard, J. P., Wagner, S., Rahrmann, E. P., Shamsan, G. A., Otto, G. M., Williams, R. L., Wang, J., Lee, C., Tschida, B. R., Das, P., Dubuc, A. M., Moriarity, B. S., Picard, D., Wu, X., Rodriguez, F. J., Rosemarie, Q., Krebs, R. D. & 13 others, Molan, A. M., Demer, A. M., Frees, M. M., Rizzardi, A. E., Schmechel, S. C., Eberhart, C. G., Jenkins, R. B., Wechsler-Reya, R. J., Odde, D. J., Huang, A., Taylor, M. D., Sarver, A. L. & Largaespada, D. A., Mar 1 2019, In : Cancer Research. 79, 5, p. 905-917 13 p.

Research output: Contribution to journalArticle

Targeting DDX3 in Medulloblastoma Using the Small Molecule Inhibitor RK-33

Tantravedi, S., Vesuna, F., Winnard, P. T., Martin, A., Lim, M., Eberhart, C. G., Berlinicke, C., Raabe, E., van Diest, P. J. & Raman, V., Jan 2019, In : Translational Oncology. 12, 1, p. 96-105 10 p.

Research output: Contribution to journalArticle

The medical necessity of advanced molecular testing in the diagnosis and treatment of brain tumor patients

Horbinski, C., Ligon, K. L., Brastianos, P., Huse, J. T., Venere, M., Chang, S., Buckner, J., Cloughesy, T., Jenkins, R. B., Giannini, C., Nabors, L. B., Wen, P. Y., Aldape, K. J., Lukas, R. V., Galanis, E., Eberhart, C. G., Brat, D. J. & Sarkaria, J. N., Dec 1 2019, In : Neuro-oncology. 21, 12, p. 1498-1508 11 p.

Research output: Contribution to journalArticle

Open Access

Unbiased metabolic profiling predicts sensitivity of high MYC-expressing atypical teratoid/ rhabdoid tumors to glutamine inhibition with 6-diazo-5-oxo-L-norleucine

Wang, S. Z., Poore, B., Alt, J., Price, A., Allen, S. J., Hanaford, A. R., Kaur, H., Orr, B. A., Slusher, B. S., Eberhart, C. G., Raabe, E. H. & Rubens, J. A., Oct 1 2019, In : Clinical Cancer Research. 25, 19, p. 5925-5936 12 p.

Research output: Contribution to journalArticle

2018

ACVR1C/SMAD2 signaling promotes invasion and growth in retinoblastoma

Asnaghi, L., White, D. T., Key, N., Choi, J., Mahale, A., Alkatan, H., Edward, D. P., Elkhamary, S. M., Al-Mesfer, S., Maktabi, A., Hurtado, C. G., Lee, G. Y., Carcaboso, A. M., Mumm, J., Safieh, L. A. & Eberhart, C. G., Jan 1 2018, (Accepted/In press) In : Oncogene.

Research output: Contribution to journalArticle

Association of macular and peripheral retinal macro-pseudocysts with chronic retinal detachment

Alvin Liu, T. Y., Adelita Vizcaino, M., Eberhart, C. G. & Sachdeva, M. M., Aug 1 2018, In : JAMA Ophthalmology. 136, 8, p. 956-958 3 p.

Research output: Contribution to journalLetter

ATRX loss induces multiple hallmarks of the alternative lengthening of telomeres (ALT) phenotype in human glioma cell lines in a cell line-specific manner

Brosnan-Cashman, J. A., Yuan, M., Graham, M. K., Rizzo, A. J., Myers, K. M., Davis, C., Zhang, R., Esopi, D. M., Raabe, E., Eberhart, C. G., Heaphy, C. M. & Meeker, A. K., Sep 1 2018, In : PLoS One. 13, 9, e0204159.

Research output: Contribution to journalArticle

Bioreducible Polymeric Nanoparticles Containing Multiplexed Cancer Stem Cell Regulating miRNAs Inhibit Glioblastoma Growth and Prolong Survival

Lopez-Bertoni, H., Kozielski, K. L., Rui, Y., Lal, B., Vaughan, H., Wilson, D. R., Mihelson, N., Eberhart, C. G., Laterra, J. J. & Green, J., Jul 11 2018, In : Nano Letters. 18, 7, p. 4086-4094 9 p.

Research output: Contribution to journalArticle

Development and optimization of metagenomic next-generation sequencing methods for cerebrospinal fluid diagnostics

Simner, P. J., Miller, H. B., Breitwieser, F. P., Monsalve, G. P., Pardo, C. A., Salzberg, S. L., Sears, C. L., Thomas, D. L., Eberhart, C. G. & Carrolla, K. C., Sep 2018, In : Journal of clinical microbiology. 56, 9, e00472.

Research output: Contribution to journalArticle

Endocrine mucin-producing sweat gland carcinoma: A study of 11 cases with molecular analysis

Qin, H., Moore, R. F., Ho, C. Y., Eshleman, J., Eberhart, C. G. & Cuda, J., Sep 1 2018, In : Journal of Cutaneous Pathology. 45, 9, p. 681-687 7 p.

Research output: Contribution to journalArticle

Heterogeneity within the PF-EPN-B ependymoma subgroup

Cavalli, F. M. G., Hübner, J. M., Sharma, T., Luu, B., Sill, M., Zapotocky, M., Mack, S. C., Witt, H., Lin, T., Shih, D. J. H., Ho, B., Santi, M., Emery, L., Hukin, J., Dunham, C., McLendon, R. E., Lipp, E. S., Gururangan, S., Grossbach, A., French, P. & 37 others, Kros, J. M., van Veelen, M. L. C., Rao, A. A. N., Giannini, C., Leary, S., Jung, S., Faria, C. C., Mora, J., Schüller, U., Alonso, M. M., Chan, J. A., Klekner, A., Chambless, L. B., Hwang, E. I., Massimino, M., Eberhart, C. G., Karajannis, M. A., Lu, B., Liau, L. M., Zollo, M., Ferrucci, V., Carlotti, C., Tirapelli, D. P. C., Tabori, U., Bouffet, E., Ryzhova, M., Ellison, D. W., Merchant, T. E., Gilbert, M. R., Armstrong, T. S., Korshunov, A., Pfister, S. M., Taylor, M. D., Aldape, K., Pajtler, K. W., Kool, M. & Ramaswamy, V., Aug 1 2018, In : Acta neuropathologica. 136, 2, p. 227-237 11 p.

Research output: Contribution to journalArticle

Identifying corneal infections in formalin-fixed specimens using next generation sequencing

Li, Z., Breitwieser, F. P., Lu, J., Jun, A. S., Asnaghi, L., Salzberg, S. L. & Eberhart, C. G., Jan 2018, In : Investigative Ophthalmology and Visual Science. 59, 1, p. 280-288 9 p.

Research output: Contribution to journalArticle

MicroRNA (miR) 125b regulates cell growth and invasion in pediatric low grade glioma

Yuan, M., Da Silva, A. C. A. L., Arnold, A., Okeke, L., Ames, H., Correa-Cerro, L. S., Vizcaino, M. A., Ho, C. Y., Eberhart, C. G. & Rodriguez, F. J., Dec 1 2018, In : Scientific Reports. 8, 1, 12506.

Research output: Contribution to journalArticle