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  • Henry Brem
2020

Impact of COVID-19 on an Academic Neurosurgery Department: The Johns Hopkins Experience

Khalafallah, A. M., Jimenez, A. E., Lee, R. P., Weingart, J. D., Theodore, N., Cohen, A. R., Tamargo, R. J., Huang, J., Brem, H. & Mukherjee, D., Jan 1 2020, (Accepted/In press) In : World neurosurgery.

Research output: Contribution to journalArticle

Open Access

Intraoperative Laser Speckle Contrast Imaging For Real-Time Visualization of Cerebral Blood Flow in Cerebrovascular Surgery: Results From Pre-Clinical Studies

Mangraviti, A., Volpin, F., Cha, J., Cunningham, S. I., Raje, K., Brooke, M. J., Brem, H., Olivi, A., Huang, J., Tyler, B. M. & Rege, A., Dec 1 2020, In : Scientific reports. 10, 1, 7614.

Research output: Contribution to journalArticle

Open Access

Nonviral polymeric nanoparticles for gene therapy in pediatric CNS malignancies

Choi, J., Rui, Y., Kim, J., Gorelick, N., Wilson, D. R., Kozielski, K., Mangraviti, A., Sankey, E., Brem, H., Tyler, B., Green, J. J. & Jackson, E. M., Jan 2020, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 23, 102115.

Research output: Contribution to journalArticle

Novel therapeutics for brain tumors: current practice and future prospects

El Demerdash, N., Kedda, J., Ram, N., Brem, H. & Tyler, B., Jan 2 2020, In : Expert Opinion on Drug Delivery. 17, 1, p. 9-21 13 p.

Research output: Contribution to journalReview article

Risk of Complications in Primary Versus Revision-Type Cranioplasty

Shay, T., Belzberg, M., Asemota, A. O., Mitchell, K. A., Wolff, A., Santiago, G. F., Huang, J., Brem, H. & Gordon, C. R., Mar 1 2020, In : The Journal of craniofacial surgery. 31, 2, p. 423-427 5 p.

Research output: Contribution to journalArticle

2019

Biodegradable wafers releasing Temozolomide and Carmustine for the treatment of brain cancer

Shapira-Furman, T., Serra, R., Gorelick, N., Doglioli, M., Tagliaferri, V., Cecia, A., Peters, M., Kumar, A., Rottenberg, Y., Langer, R., Brem, H., Tyler, B. & Domb, A. J., Feb 10 2019, In : Journal of Controlled Release. 295, p. 93-101 9 p.

Research output: Contribution to journalArticle

Combination anti-CXCR4 and anti-PD-1 immunotherapy provides survival benefit in glioblastoma through immune cell modulation of tumor microenvironment

Wu, A., Maxwell, R., Xia, Y., Cardarelli, P., Oyasu, M., Belcaid, Z., Kim, E., Hung, A., Luksik, A. S., Garzon-Muvdi, T., Jackson, C. M., Mathios, D., Theodros, D., Cogswell, J., Brem, H., Pardoll, A. M. & Lim, M., Jan 1 2019, In : Journal of neuro-oncology.

Research output: Contribution to journalArticle

Costs and Their Predictors in Transsphenoidal Pituitary Surgery

Asemota, A. O., Ishii, M., Brem, H. & Gallia, G. L., Nov 1 2019, In : Clinical Neurosurgery. 85, 5, p. 695-707 13 p.

Research output: Contribution to journalArticle

Deferred radiotherapy after debulking of non-functioning pituitary macroadenomas: Clinical outcomes

Nicholas, S. E., Salvatori, R., Quinones-Hinojosa, A., Redmond, K. A., Gallia, G. L., Lim, M., Rigamonti, D., Brem, H. & Kleinberg, L. R., Jan 1 2019, In : Frontiers in Oncology. 9, JAN, 660.

Research output: Contribution to journalArticle

Open Access

Drug-Impregnated Polymer Delivery

Serra, R., Casaos, J., Tyler, B. & Brem, H., Jun 25 2019, Nervous System Drug Delivery: Principles and Practice. Elsevier, p. 275-296 22 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

First-in-Human Experience With Integration of a Hydrocephalus Shunt Device Within a Customized Cranial Implant

Gordon, C. R., Wolff, A., Santiago, G. F., Liebman, K., Veznedaroglu, E., Vrionis, F. D., Huang, J., Brem, H. & Luciano, M., Dec 1 2019, In : Operative neurosurgery (Hagerstown, Md.). 17, 6, p. 608-615 8 p.

Research output: Contribution to journalArticle

Open Access

Full-Thickness Skin Grafting for Local Defect Coverage Following Scalp Adjacent Tissue Transfer in the Setting of Cranioplasty

Wolff, A. Y., Santiago, G. F., Belzberg, M., Manson, P., Huang, J., Brem, H. & Gordon, C. R., Jan 1 2019, In : The Journal of craniofacial surgery. 30, 1, p. 115-119 5 p.

Research output: Contribution to journalArticle

Genome-wide investigation of intragenic DNA methylation identifies ZMIZ1 gene as a prognostic marker in glioblastoma and multiple cancer types

Mathios, D., Hwang, T., Xia, Y., Phallen, J., Rui, Y., See, A. P., Maxwell, R., Belcaid, Z., Casaos, J., Burger, P. C., McDonald, K. L., Gallia, G. L., Cope, L., Kai, M., Brem, H., Pardoll, A. M., Ha, P., Green, J., Velculescu, V. E., Bettegowda, C. & 2 others, Park, C. K. & Lim, M., Jan 1 2019, (Accepted/In press) In : International Journal of Cancer.

Research output: Contribution to journalArticle

Minimally invasive intraventricular ultrasound: Design and instrumentation towards a miniaturized ultrasound-guided focused ultrasound probe

Belzberg, M., Chavez, F., Xiong, K. T., Morrison, K., Gamo, N., Restaino, S., Iyer, R., Groves, M., Thakor, N., Brem, H., Cohen, A. & Manbachi, A., Jan 1 2019, Medical Imaging 2019: Image-Guided Procedures, Robotic Interventions, and Modeling. Fei, B. & Linte, C. A. (eds.). SPIE, 109512Y. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 10951).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Multi-layered core-sheath fiber membranes for controlled drug release in the local treatment of brain tumor

Han, D., Serra, R., Gorelick, N., Fatima, U., Eberhart, C. G., Brem, H., Tyler, B. & Steckl, A. J., Dec 1 2019, In : Scientific reports. 9, 1, 17936.

Research output: Contribution to journalArticle

Open Access

Overall survival in malignant glioma is significantly prolonged by neurosurgical delivery of etoposide and temozolomide from a thermo-responsive biodegradable paste

Smith, S. J., Tyler, B. M., Gould, T., Veal, G. J., Gorelick, N., Rowlinson, J., Serra, R., Ritchie, A., Berry, P., Otto, A., Choi, J., Skuli, N., Estevez-Cebrero, M., Shakesheff, K. M., Brem, H., Grundy, R. G. & Rahman, R., Aug 15 2019, In : Clinical Cancer Research. 25, 16, p. 5094-5106 13 p.

Research output: Contribution to journalArticle

Open Access

Pharmacokinetics of Polymeric Drug Delivery

Serra, R., Huq, S., Brem, H. & Tyler, B., Jun 25 2019, Nervous System Drug Delivery: Principles and Practice. Elsevier, p. 91-109 19 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Sonolucent cranial implants: Cadaveric study and clinical findings supporting diagnostic and therapeutic transcranioplasty ultrasound

Belzberg, M., Shalom, N. B., Yuhanna, E., Manbachi, A., Tekes, A., Huang, J., Brem, H. & Gordon, C. R., Jan 1 2019, In : Journal of Craniofacial Surgery. 30, 5, p. 1456-1461 6 p.

Research output: Contribution to journalArticle

The use of ribavirin as an anticancer therapeutic: Will it go viral?

Casaos, J., Gorelick, N. L., Huq, S., Choi, J., Xia, Y., Serra, R., Felder, R., Lott, T., Kast, R. E., Suk, I., Brem, H., Tyler, B. & Skuli, N., Jan 1 2019, In : Molecular cancer therapeutics. 18, 7, p. 1185-1194 10 p.

Research output: Contribution to journalReview article

2018

Adult cranioplasty reconstruction with customized cranial implants: Preferred technique, timing, and biomaterials

Wolff, A., Santiago, G. F., Belzberg, M., Huggins, C., Lim, M., Weingart, J. D., Anderson, W. S., Coon, A., Huang, J., Brem, H. & Gordon, C. R., Jun 1 2018, In : Journal of Craniofacial Surgery. 29, 4, p. 887-894 8 p.

Research output: Contribution to journalArticle

Contrasting impact of corticosteroids on anti-PD-1 immunotherapy efficacy for tumor histologies located within or outside the central nervous system

Maxwell, R., Luksik, A. S., Garzon-Muvdi, T., Hung, A. L., Kim, E. S., Wu, A., Xia, Y., Belcaid, Z., Gorelick, N., Choi, J., Theodros, D., Jackson, C. M., Mathios, D., Ye, X., Tran, P. T., Redmond, K. A., Brem, H., Pardoll, A. M., Kleinberg, L. R. & Lim, M., Jan 1 2018, (Accepted/In press) In : OncoImmunology.

Research output: Contribution to journalArticle

Dendritic cell activation enhances anti-PD-1 mediated immunotherapy against glioblastoma

Garzon-Muvdi, T., Theodros, D., Luksik, A. S., Maxwell, R., Kim, E., Jackson, C. M., Belcaid, Z., Ganguly, S., Tyler, B., Brem, H., Pardoll, D. M. & Lim, M., Apr 17 2018, In : Oncotarget. 9, 29, p. 20681-20697 17 p.

Research output: Contribution to journalArticle

Ethical issues and recommendations in grateful patient fundraising and philanthropy

Collins, M. E., Rum, S., Wheeler, J., Antman, K., Brem, H., Carrese, J., Glennon, M., Kahn, J., Ohman, E. M., Jagsi, R., Konrath, S., Tovino, S., Wright, S. & Sugarman, J., Jan 1 2018, In : Academic Medicine. 93, 11, p. 1631-1637 7 p.

Research output: Contribution to journalReview article

Expression of LAG-3 and efficacy of combination treatment with anti-LAG-3 and anti-PD-1 monoclonal antibodies in glioblastoma

Harris-Bookman, S., Mathios, D., Martin, A. M., Xia, Y., Kim, E., Xu, H., Belcaid, Z., Polanczyk, M., Barberi, T., Theodros, D., Kim, J., Taube, J. M., Burger, P. C., Selby, M., Taitt, C., Korman, A., Ye, X., Drake, C. G., Brem, H., Pardoll, D. M. & 1 others, Lim, M., Dec 15 2018, In : International Journal of Cancer. 143, 12, p. 3201-3208 8 p.

Research output: Contribution to journalArticle

Interstitial Chemotherapy and Polymer Drug Delivery

Gorelick, N., Jackson, E., Tyler, B. M. & Brem, H., Apr 24 2018, Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy: Second Edition. Elsevier Inc., p. 155-165 11 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Neuroplastic Surgery

Gordon, C. R., Huang, J. & Brem, H., Jan 1 2018, In : Journal of Craniofacial Surgery. 29, 1, p. 4-5 2 p.

Research output: Contribution to journalEditorial

Post-Neurosurgical Temporal Deformities: Various Techniques for Correction and Associated Complications

Santiago, G. F., Terner, J., Wolff, A., Teixeira, J., Brem, H., Huang, J. & Gordon, C. R., Oct 1 2018, In : The Journal of craniofacial surgery. 29, 7, p. 1723-1729 7 p.

Research output: Contribution to journalArticle

Ribavirin as a potential therapeutic for atypical teratoid/rhabdoid tumors

Casaos, J., Huq, S., Lott, T., Felder, R., Choi, J., Gorelick, N., Peters, M., Xia, Y., Maxwell, R., Zhao, T., Ji, C., Simon, T., Sesen, J., Scotland, S. J., Kast, R. E., Rubens, J., Raabe, E., Eberhart, C. G., Jackson, E. M., Brem, H. & 2 others, Tyler, B. & Skuli, N., Jan 1 2018, In : Oncotarget. 9, 8, p. 8054-8067 14 p.

Research output: Contribution to journalArticle

Risk of Developing Postoperative Deficits Based on Tumor Location after Surgical Resection of an Intracranial Meningioma

Ehresman, J. S., Garzon-Muvdi, T., Rogers, D., Lim, M., Gallia, G. L., Weingart, J. D., Brem, H., Bettegowda, C. & Chaichana, K. L., Jul 17 2018, (Accepted/In press) In : Journal of Neurological Surgery, Part B: Skull Base.

Research output: Contribution to journalArticle

Targeted Local Therapy for Management of Intracranial High-Grade Gliomas

Paldor, I., Chaichana, K. L., Brem, H. & Tyler, B. M., Jan 1 2018, In : Progress in neurological surgery. 32, p. 159-171 13 p.

Research output: Contribution to journalArticle

The Relevance of Simpson Grade Resections in Modern Neurosurgical Treatment of World Health Organization Grade I, II, and III Meningiomas

Ehresman, J. S., Garzon-Muvdi, T., Rogers, D., Lim, M., Gallia, G. L., Weingart, J. D., Brem, H., Bettegowda, C. & Chaichana, K. L., Jan 1 2018, In : World Neurosurgery. 109, p. e588-e593

Research output: Contribution to journalArticle

TIGIT and PD-1 dual checkpoint blockade enhances antitumor immunity and survival in GBM

Hung, A. L., Maxwell, R., Theodros, D., Belcaid, Z., Mathios, D., Luksik, A. S., Kim, E., Wu, A., Xia, Y., Garzon-Muvdi, T., Jackson, C., Ye, X., Tyler, B. M., Selby, M., Korman, A., Barnhart, B., Park, S. M., Youn, J. I., Chowdhury, T., Park, C. K. & 3 others, Brem, H., Pardoll, A. M. & Lim, M., May 23 2018, (Accepted/In press) In : OncoImmunology.

Research output: Contribution to journalArticle

2016

Agonist anti-GITR monoclonal antibody and stereotactic radiation induce immune-mediated survival advantage in murine intracranial glioma

Patel, M. A., Kim, J. E., Theodros, D., Tam, A., Velarde, E., Kochel, C. M., Francica, B., Nirschl, T. R., Ghasemzadeh, A., Mathios, D., Harris-Bookman, S., Jackson, C. C., Jackson, C., Ye, X., Tran, P. T., Tyler, B., Coric, V., Selby, M., Brem, H., Drake, C. G. & 2 others, Pardoll, D. M. & Lim, M., May 17 2016, In : Journal for immunotherapy of cancer. 4, 1, 28.

Research output: Contribution to journalArticle

Anticoagulation for Hypercoagulable Patients Associated with Complications after Large Cranioplasty Reconstruction

Sankey, E. W., Lopez, J., Zhong, S. S., Susarla, H., Jusué-Torres, I., Liauw, J., Huang, J., Streiff, M., Brem, H. & Gordon, C. R., Feb 1 2016, In : Plastic and reconstructive surgery. 137, 2, p. 595-607 13 p.

Research output: Contribution to journalArticle

Anti-PD-1 antitumor immunity is enhanced by local and abrogated by systemic chemotherapy in GBM

Mathios, D., Kim, J. E., Mangraviti, A., Phallen, J., Park, C. K., Jackson, C. M., Garzon-Muvdi, T., Kim, E., Theodros, D., Polanczyk, M., Martin, A., Suk, I., Ye, X., Tyler, B. M., Bettegowda, C., Brem, H., Pardoll, A. M. & Lim, M., Dec 21 2016, In : Science Translational Medicine. 8, 370, 370ra180.

Research output: Contribution to journalArticle

Convection enhanced delivery of cisplatin-loaded brain penetrating nanoparticles cures malignant glioma in rats

Zhang, C., Nance, E. A., Mastorakos, P., Chisholm, J., Berry, S., Eberhart, C. G., Tyler, B. M., Brem, H., Suk, J. S. & Hanes, J. S., Dec 5 2016, (Accepted/In press) In : Journal of Controlled Release.

Research output: Contribution to journalArticle

Erratum to: Agonist anti-GITR monoclonal antibody and stereotactic radiation induce immune-mediated survival advantage in murine intracranial glioma [J Immunothera Cancer, 4, (2016), (28)] DOI:10.1186/s40425-016-0132-2

Patel, M. A., Kim, J. E., Theodros, D., Tam, A., Velarde, E., Kochel, C. M., Francica, B., Nirschl, T. R., Ghasemzadeh, A., Mathios, D., Harris-Bookman, S., Jackson, C. C., Jackson, C., Ye, X., Tran, P. T., Tyler, B., Coric, V., Selby, M., Brem, H., Drake, C. G. & 2 others, Pardoll, D. M. & Lim, M., Nov 4 2016, In : Journal for immunotherapy of cancer. 4, 1, 74.

Research output: Contribution to journalComment/debate

Establishment and biological characterization of a panel of glioblastoma multiforme (GBM) and GBM variant oncosphere cell lines

Binder, Z. A., Wilson, K. M., Salmasi, V., Orr, B. A., Eberhart, C. G., Siu, I. M., Lim, M., Weingart, J. D., Quinones-Hinojosa, A., Bettegowda, C., Kassam, A. B., Olivi, A., Brem, H., Riggins, G. J. & Gallia, G. L., Mar 1 2016, In : PLoS One. 11, 3, e0150271.

Research output: Contribution to journalArticle

Highlights of Children with Cancer UK's Workshop on Drug Delivery in Paediatric Brain Tumours

Nailor, A., Walker, D. A., Jacques, T. S., Warren, K. E., Brem, H., Kearns, P. R., Greenwood, J., Penny, J. I., Pilkington, G. J., Carcaboso, A. M., Fleischhack, G., Macarthur, D., Slavc, I., Meijer, L., Gill, S., Lowis, S., Van Vuurden, D. G., Pearl, M. S., Clifford, S. C., Morrissy, S. & 8 others, Ivanov, D. P., Beccaria, K., Gilbertson, R. J., Straathof, K., Green, J. J., Smith, S., Rahman, R. & Kilday, J. P., Mar 31 2016, In : ecancermedicalscience. 10, 630.

Research output: Contribution to journalArticle

Non-virally engineered human adipose mesenchymal stem cells produce BMP4, target brain tumors, and extend survival

Mangraviti, A., Tzeng, S., Gullotti, D., Kozielski, K. L., Kim, J. E., Seng, M., Abbadi, S., Schiapparelli, P., Sarabia-Estrada, R., Vescovi, A., Brem, H., Olivi, A., Tyler, B. M., Green, J. & Quinones-Hinojosa, A., Sep 1 2016, In : Biomaterials. 100, p. 53-66 14 p.

Research output: Contribution to journalArticle

Polylactic acid (PLA) controlled delivery carriers for biomedical applications

Tyler, B. M., Gullotti, D., Mangraviti, A., Utsuki, T. & Brem, H., Apr 25 2016, (Accepted/In press) In : Advanced Drug Delivery Reviews.

Research output: Contribution to journalArticle

Surgical complications following malignant brain tumor surgery: An analysis of 2002-2011 data

De La Garza-Ramos, R., Kerezoudis, P., Tamargo, R. J., Brem, H., Huang, J. & Bydon, M., Jan 1 2016, In : Clinical Neurology and Neurosurgery. 140, p. 6-10 5 p.

Research output: Contribution to journalArticle

Syndrome of the Trephined: A Systematic Review

Ashayeri, K., Jackson, E., Huang, J., Brem, H. & Gordon, C. R., Oct 1 2016, In : Neurosurgery. 79, 4, p. 525-533 9 p.

Research output: Contribution to journalArticle

Synthesis, characterization, and self-assembly with plasmid DNA of a quaternary ammonium derivative of pectic galactan and its fluorescent labeling for bioimaging applications

Chintakunta, R., Buaron, N., Kahn, N., Moriah, A., Lifshiz, R., Goldbart, R., Traitel, T., Tyler, B. M., Brem, H. & Kost, J., Oct 5 2016, In : Carbohydrate Polymers. 150, p. 308-318 11 p.

Research output: Contribution to journalArticle