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2019

A Connective Tissue Mast-Cell-Specific Receptor Detects Bacterial Quorum-Sensing Molecules and Mediates Antibacterial Immunity

Pundir, P., Liu, R., Vasavda, C., Serhan, N., Limjunyawong, N., Yee, R., Zhan, Y., Dong, X., Wu, X., Zhang, Y., Snyder, S. H., Gaudenzio, N., Vidal, J. E. & Dong, X., Jul 10 2019, In : Cell Host and Microbe. 26, 1, p. 114-122.e8

Research output: Contribution to journalArticle

Connective Tissue Cells
Quorum Sensing
Mast Cells
Immunity
Bacteria

Bilirubin Links Heme Metabolism to Neuroprotection by Scavenging Superoxide

Vasavda, C., Kothari, R., Malla, A. P., Tokhunts, R., Lin, A., Ji, M., Ricco, C., Xu, R., Saavedra, H. G., Sbodio, J. I., Snowman, A. M., Albacarys, L., Hester, L. D., Sedlak, T. W., Paul, B. & Snyder, S. H., Oct 17 2019, In : Cell Chemical Biology. 26, 10, p. 1450-1460.e7

Research output: Contribution to journalArticle

Scavenging
Heme
Bilirubin
Metabolism
Superoxides

Histone H2AX promotes neuronal health by controlling mitochondrial homeostasis

Weyemi, S., Paul, B., Bhattacharya, D., Malla, A. P., Boufraqech, M., Harraz, M., Bonner, W. M. & Snyder, S. H., Apr 9 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 15, p. 7471-7476 6 p.

Research output: Contribution to journalArticle

Histones
Homeostasis
Brain Death
Mitochondrial Genes
Oxidative Phosphorylation

Identification of a bilirubin receptor that may mediate a component of cholestatic itch

Meixiong, J., Vasavda, C., Green, D., Zheng, Q., Qi, L., Kwatra, S., Hamilton, J., Snyder, S. H. & Dong, X., Jan 21 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access
Bilirubin
Jaundice
biliverdin reductase
Sensory Receptor Cells
Neurons
Open Access
Huntington Disease
Oxidation-Reduction
Antioxidants
Therapeutics
Defense Mechanisms

Inositol hexakisphosphate kinase 3 promotes focal adhesion turnover via interactions with dynein intermediate chain 2

Rojas, T., Cheng, W., Gao, Z., Liu, X., Wang, Y., Malla, A. P., Chin, A. C., Romer, L., Snyder, S. H. & Fu, C., Feb 19 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 8, p. 3278-3287 10 p.

Research output: Contribution to journalArticle

Dyneins
Focal Adhesions
Fluorescence Microscopy
Cell Movement
Brain

Inositol polyphosphate multikinase mediates extinction of fear memory

Park, J., Longo, F., Park, S. J., Lee, S., Bae, M., Tyagi, R., Han, J. H., Kim, S., Santini, E., Klann, E. & Snyder, S. H., Feb 12 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 7, p. 2707-2712 6 p.

Research output: Contribution to journalArticle

Fear
Ribosomal Protein S6 Kinases
Polyphosphates
Long-Term Potentiation
Inositol

IPMK Mediates Activation of ULK Signaling and Transcriptional Regulation of Autophagy Linked to Liver Inflammation and Regeneration

Guha, P., Tyagi, R., Chowdhury, S., Reilly, L., Fu, C., Xu, R., Resnick, A. C. & Snyder, S. H., Mar 5 2019, In : Cell Reports. 26, 10, p. 2692-2703.e7

Research output: Contribution to journalArticle

Open Access
Liver Regeneration
Autophagy
Liver
Chemical activation
Inflammation
Pruritus
G-Protein-Coupled Receptors
Bile Acids and Salts
Sensory Receptor Cells
Injections
Liver Regeneration
Autophagy
AMP-Activated Protein Kinases
inositol polyphosphate multikinase
Histones

Redox Mechanisms in Neurodegeneration: From Disease Outcomes to Therapeutic Opportunities

Sbodio, J., Snyder, S. H. & Paul, B., Jan 1 2019, In : Antioxidants and Redox Signaling. 30, 11, p. 1450-1499 50 p.

Research output: Contribution to journalReview article

Oxidation-Reduction
Therapeutics
Neurodegenerative Diseases
Sulfur
Brain

Selective Persulfide Detection Reveals Evolutionarily Conserved Antiaging Effects of S-Sulfhydration

Zivanovic, J., Kouroussis, E., Kohl, J. B., Adhikari, B., Bursac, B., Schott-Roux, S., Petrovic, D., Miljkovic, J. L., Thomas-Lopez, D., Jung, Y., Miler, M., Mitchell, S., Milosevic, V., Gomes, J. E., Benhar, M., Gonzales-Zorn, B., Ivanovic-Burmazovic, I., Torregrossa, R., Mitchell, J. R., Whiteman, M. & 5 others, Schwarz, G., Snyder, S. H., Paul, B. D., Carroll, K. S. & Filipovic, M. R., Dec 3 2019, In : Cell Metabolism. 30, 6, p. 1152-1170.e13

Research output: Contribution to journalArticle

Post Translational Protein Processing
Oxidative Stress
Pharmacology
Proteins
persulfides
Glutathione
Glutamic Acid
Miniature Postsynaptic Potentials
Excitatory Postsynaptic Potentials
Neurotransmitter Agents
2018

Bryostatin-1 alleviates experimental multiple sclerosis

Kornberg, M., Smith, M. D., Shirazi, H. A., Calabresi, P., Snyder, S. H. & Kim, P., Feb 27 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 9, p. 2186-2191 6 p.

Research output: Contribution to journalArticle

Multiple Sclerosis
Autoimmune Experimental Encephalomyelitis
Antigen-Presenting Cells
Myeloid Cells
Lymphocytes

Chapter 2: Production of NO - The l-arginine/NOS/NO System

Paul, B. & Snyder, S. H., Jan 1 2018, RSC Metallobiology. 12 ed. Royal Society of Chemistry, p. 29-43 15 p. (RSC Metallobiology; vol. 2018-January, no. 12).

Research output: Chapter in Book/Report/Conference proceedingChapter

Arginine
Nitric Oxide
Molecules
Gasotransmitters
Cloning

Cysteine Metabolism in Neuronal Redox Homeostasis

Paul, B., Sbodio, J. & Snyder, S. H., Jan 1 2018, (Accepted/In press) In : Trends in Pharmacological Sciences.

Research output: Contribution to journalArticle

Metabolism
Oxidation-Reduction
Cysteine
Homeostasis
Brain

Dimethyl fumarate targets GAPDH and aerobic glycolysis to modulate immunity

Kornberg, M., Bhargava, P., Kim, P., Putluri, V., Snowman, A. M., Putluri, N., Calabresi, P. & Snyder, S. H., Mar 29 2018, (Accepted/In press) In : Science. p. 1-9 9 p.

Research output: Contribution to journalArticle

Glycolysis
Immunity
Cysteine
Fumarates
Citric Acid Cycle

Gasotransmitter hydrogen sulfide signaling in neuronal health and disease

Paul, B. & Snyder, S. H., Mar 1 2018, In : Biochemical Pharmacology. 149, p. 101-109 9 p.

Research output: Contribution to journalReview article

Gasotransmitters
Hydrogen Sulfide
Health
Neurodegenerative diseases
Huntington Disease
Cystathionine
Cytoprotection
Huntington Disease
Monensin
Cysteine

Histone H2AX deficiency causes neurobehavioral deficits and impaired redox homeostasis

Weyemi, S., Paul, B., Snowman, A. M., Jailwala, P., Nussenzweig, A., Bonner, W. M. & Snyder, S. H., Dec 1 2018, In : Nature Communications. 9, 1, 1526.

Research output: Contribution to journalArticle

homeostasis
Histones
Oxidation-Reduction
Reactive Oxygen Species
Homeostasis

Inhibition of IP6K1 suppresses neutrophil-mediated pulmonary damage in bacterial pneumonia

Hou, Q., Liu, F., Chakraborty, A., Jia, Y., Prasad, A., Yu, H., Zhao, L., Ye, K., Snyder, S. H., Xu, Y. & Luo, H. R., Apr 4 2018, In : Science Translational Medicine. 10, 435, eaal4045.

Research output: Contribution to journalArticle

Bacterial Pneumonia
Neutrophils
Polyphosphates
Lung
Bradykinin

Inositol hexakisphosphate kinase-2 in cerebellar granule cells regulates Purkinje cells and motor coordination via protein 4.1N

Nagpal, L., Fu, C. & Snyder, S. H., Aug 22 2018, In : Journal of Neuroscience. 38, 34, p. 7409-7419 11 p.

Research output: Contribution to journalArticle

Purkinje Cells
Biological Phenomena
Diphosphates
Synapses
Cerebellum

Inositol polyphosphate multikinase inhibits angiogenesis via inositol pentakisphosphate-induced HIF-1α degradation

Fu, C., Tyagi, R., Chin, A. C., Rojas, T., Li, R. J., Guha, P., Bernstein, I. A., Rao, F., Xu, R., Cha, J., Xu, J., Snowman, A. M., Semenza, G. L. & Snyder, S. H., Feb 2 2018, In : Circulation Research. 122, 3, p. 457-472 16 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Vascular Endothelial Growth Factor A
Hydroxylation
inositol polyphosphate multikinase
inositol pentaphosphate

Multiple aspects of male germ cell development and interactions with Sertoli cells require inositol hexakisphosphate kinase-1

Fu, C., Rojas, T., Chin, A. C., Cheng, W., Bernstein, I. A., Albacarys, L. K., Wright, W. W. & Snyder, S. H., Dec 1 2018, In : Scientific Reports. 8, 1, 7039.

Research output: Contribution to journalArticle

Sertoli Cells
Germ Cells
Cell Communication
Spermatozoa
Acrosome

Regulators of the transsulfuration pathway

Sbodio, J., Snyder, S. H. & Paul, B., Jan 1 2018, (Accepted/In press) In : British Journal of Pharmacology.

Research output: Contribution to journalArticle

Cystathionine
Cysteine
Hydrogen Sulfide
Sulfur
Lyases

The brain harbors many neurotransmitters

Snyder, S. H., Apr 24 2018, Think Tank: Forty Neuroscientists Explore the Biological Roots of Human Experience. Yale University Press, p. 88-94 7 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Ports and harbors
Neurotransmitter Agents
Brain
2017

A Life of Neurotransmitters

Snyder, S. H., Jan 6 2017, In : Annual Review of Pharmacology and Toxicology. 57, p. 1-11 11 p.

Research output: Contribution to journalReview article

Mentors
Creativity
Neurotransmitter Agents
Students
Molecules

Antidepressant Actions of Ketamine Mediated by the Mechanistic Target of Rapamycin, Nitric Oxide, and Rheb

Harraz, M. & Snyder, S. H., Jul 1 2017, In : Neurotherapeutics. 14, 3, p. 728-733 6 p.

Research output: Contribution to journalReview article

Ketamine
Sirolimus
Antidepressive Agents
Nitric Oxide
Ternary Complex Factors

Complementary roles of gasotransmitters CO and H2S in sleep apnea

Peng, Y. J., Zhang, X., Gridina, A., Chupikova, I., Mccormick, D. L., Thomas, R. J., Scammell, T. E., Kim, G., Vasavda, C., Nanduri, J., Kumar, G. K., Semenza, G. L., Snyder, S. H. & Prabhakar, N. R., Feb 7 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 6, p. 1413-1418 6 p.

Research output: Contribution to journalArticle

Gasotransmitters
Carotid Body
Sleep Apnea Syndromes
Apnea
Carbon Monoxide

Developmental alcohol exposure impairs activity-dependent S-nitrosylation of NDEL1 for neuronal maturation

Saito, A., Taniguchi, Y., Kim, S-H., Selvakumar, B., Perez, G., Ballinger, M. D., Zhu, X., Sabra, J., Jallow, M., Yan, P., Ito, K., Rajendran, S., Hirotsune, S., Wynshaw-Boris, A., Snyder, S. H., Sawa, A. & Kamiya, A., Aug 1 2017, In : Cerebral Cortex. 27, 8, p. 3918-3929 12 p.

Research output: Contribution to journalArticle

Cyclic GMP
Alcohols
Brain
Maternal Exposure
Nitric Oxide Synthase Type I

DISC1 in Astrocytes Influences Adult Neurogenesis and Hippocampus-Dependent Behaviors in Mice

Terrillion, C., Abazyan, B., Yang, Z., Crawford, J., Shevelkin, A., Jouroukhin, Y., Yoo, K. H., Cho, C. H., Roychaudhuri, R., Snyder, S. H., Jang, M. H. & Pletnikov, M., Oct 1 2017, In : Neuropsychopharmacology. 42, 11, p. 2242-2251 10 p.

Research output: Contribution to journalArticle

Neurogenesis
Astrocytes
Hippocampus
Schizophrenia
Serine

Disease onset in X-linked dystonia-parkinsonism correlates with expansion of a hexameric repeat within an SVA retrotransposon in TAF1

Bragg, D. C., Mangkalaphiban, K., Vaine, C. A., Kulkarni, N. J., Shin, D., Yadav, R., Dhakal, J., Ton, M. L., Cheng, A., Russo, C. T., Ang, M., Acuña, P., Go, C., Franceour, T. N., Multhaupt-Buell, T., Ito, N., Müller, U., Hendriks, W. T., Breakefield, X. O., Sharma, N. & 2 others, Ozelius, L. J. & Snyder, S. H., Dec 19 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 51, p. E11020-E11028

Research output: Contribution to journalArticle

Short Interspersed Nucleotide Elements
Retroelements
Minisatellite Repeats
Luciferases
TATA-Binding Protein Associated Factors

Measuring g-protein-coupled receptor signaling via radio-labeled GTP binding

Vasavda, C., Zaccor, N. W., Scherer, P. C., Sumner, C. & Snyder, S. H., Jun 9 2017, In : Journal of Visualized Experiments. 2017, 124, e55561.

Research output: Contribution to journalArticle

G-Protein-Coupled Receptors
Guanosine Triphosphate
Radio
Proteins
GTP-Binding Proteins

Mutant Huntingtin Disrupts the Nuclear Pore Complex

Grima, J. C., Daigle, J. G., Arbez, N., Cunningham, K. C., Zhang, K., Ochaba, J., Geater, C., Morozko, E., Stocksdale, J., Glatzer, J. C., Pham, J. T., Ahmed, I., Peng, Q., Wadhwa, H., Pletnikova, O., Troncoso, J. C., Duan, W., Snyder, S. H., Ranum, L. P. W., Thompson, L. M. & 3 others, Lloyd, T., Ross, C. A. & Rothstein, J. D., Apr 5 2017, In : Neuron. 94, 1, p. 93-107.e6

Research output: Contribution to journalArticle

Nuclear Pore
Nuclear Pore Complex Proteins
Cell Nucleus Active Transport
Huntington Disease
Neurons

Neuronal migration is mediated by inositol hexakisphosphate kinase 1 via α-actinin and focal adhesion kinase

Fu, C., Xu, J., Cheng, W., Rojas, T., Chin, A. C., Snowman, A. M., Harraz, M. & Snyder, S. H., Feb 21 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 8, p. 2036-2041 6 p.

Research output: Contribution to journalArticle

Actinin
Focal Adhesion Protein-Tyrosine Kinases
Phosphorylation
Stress Fibers
Focal Adhesions

Opportunities for the repurposing of PARP inhibitors for the therapy of non-oncological diseases

Berger, N. A., Besson, V. C., Boulares, A. H., Bürkle, A., Chiarugi, A., Clark, R. S., Curtin, N. J., Cuzzocrea, S., Dawson, T. M., Dawson, V., Haskó, G., Liaudet, L., Moroni, F., Pacher, P., Radermacher, P., Salzman, A. L., Snyder, S. H., Soriano, F. G., Strosznajder, R. P., Sümegi, B. & 2 others, Swanson, R. A. & Szabo, C., 2017, (Accepted/In press) In : British Journal of Pharmacology.

Research output: Contribution to journalArticle

Acute Lung Injury
Therapeutics
Septic Shock
DNA Repair
Pancreatitis

TRPV1 is a physiological regulator of μ-opioid receptors

Scherer, P. C., Zaccor, N. W., Neumann, N. M., Vasavda, C., Barrow, R. K., Ewald, A., Rao, F., Sumner, C. & Snyder, S. H., Dec 19 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 51, p. 13561-13566 6 p.

Research output: Contribution to journalArticle

Transient Receptor Potential Channels
Opioid Receptors
Opioid Analgesics
GTP-Binding Proteins
Phosphorylation
2016

Antidepressant action of ketamine via mTOR is mediated by inhibition of nitrergic Rheb degradation

Harraz, M., Tyagi, R., Cortés, P. & Snyder, S. H., Mar 1 2016, In : Molecular Psychiatry. 21, 3, p. 313-319 7 p.

Research output: Contribution to journalArticle

Ketamine
Sirolimus
Antidepressive Agents
Glyceraldehyde-3-Phosphate Dehydrogenases
Excitatory Amino Acid Antagonists
Cocaine
Nitric Oxide
Autophagy
Cell Death
Caspase 3

Collybolide is a novel biased agonist of ê-opioid receptors with potent antipruritic activity

Gupta, A., Gomes, I., Bobeck, E. N., Fakira, A. K., Massaro, N. P., Sharma, I., Cavé, A., Hamm, H. E., Parello, J., Devi, L. A. & Snyder, S. H., May 24 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 21, p. 6041-6046 6 p.

Research output: Contribution to journalArticle

salvinorin A
Antipruritics
Opioid Receptors
Biological Products
Visceral Pain

Differential binding properties of some opiates and opioid peptides

Creese, I., Childers, S. R., Simantov, R. & Snyder, S. H., Jan 14 2016, Endorphins in Mental Health Research. Palgrave Macmillan, p. 366-374 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Opioid Peptides

Distinct cortical and striatal actions of a β-arrestin-biased dopamine D2 receptor ligand reveal unique antipsychotic-like properties

Urs, N. M., Gee, S. M., Pack, T. F., McCorvy, J. D., Evron, T., Snyder, J. C., Yang, X., Rodriguiz, R. M., Borrelli, E., Wetsel, W. C., Jin, J., Roth, B. L., O'Donnell, P., Caron, M. G. & Snyder, S. H., Dec 13 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 50, p. E8178-E8186

Research output: Contribution to journalArticle

Arrestin
Corpus Striatum
Dopamine D2 Receptors
Antipsychotic Agents
Ligands

Enkephalin levels in mouse brain: Diurnal variation, post-mortem degradation, and effect of cycloheximide

Childers, S. R. & Snyder, S. H., Jan 14 2016, Endorphins in Mental Health Research. Palgrave Macmillan, p. 181-188 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Enkephalins
Cycloheximide
Brain

Foreword

Snyder, S. H., 2016, In : Advances in Pharmacology. 76, p. 13-15 3 p.

Research output: Contribution to journalEditorial

H2S production by reactive oxygen species in the carotid body triggers hypertension in a rodent model of sleep apnea

Yuan, G., Peng, Y. J., Khan, S. A., Nanduri, J., Singh, A., Vasavda, C., Semenza, G. L., Kumar, G. K., Snyder, S. H. & Prabhakar, N. R., Aug 16 2016, In : Science Signaling. 9, 441, ra80.

Research output: Contribution to journalArticle

Carotid Body
Sleep Apnea Syndromes
Cystathionine
Lyases
Rodentia

Histochemical localization of the enkephalins

Uhl, G., Kuhar, M. J., Goodman, R. R. & Snyder, S. H., Jan 14 2016, Endorphins in Mental Health Research. Palgrave Macmillan, p. 74-83 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Enkephalins

Inositol hexakisphosphate (IP6) generated by IP5K mediates cullin-COP9 signalosome interactions and CRL function

Scherer, P. C., Ding, Y., Liu, Z., Xu, J., Mao, H., Barrow, J., Wei, N., Zheng, N., Snyder, S. H. & Rao, F., Mar 29 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 13, p. 3503-3508 6 p.

Research output: Contribution to journalArticle

Cullin Proteins
Phytic Acid
Ubiquitin-Protein Ligases
Polyphosphates
Ubiquitination
Huntington Disease
Activating Transcription Factor 4
Homeostasis
Amino Acids
Oxidative Stress