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2019

A Human iPSC-derived 3D platform using primary brain cancer cells to study drug development and personalized medicine

Plummer, S., Wallace, S., Ball, G., Lloyd, R., Schiapparelli, P., Quiñones-Hinojosa, A., Hartung, T. & Pamies, D., Dec 1 2019, In : Scientific Reports. 9, 1, 1407.

Research output: Contribution to journalArticle

temozolomide
Precision Medicine
Glioblastoma
Brain Neoplasms
Doxorubicin

Corrigendum to Stage-specific metabolic features of differentiating neurons: Implications for toxicant sensitivity(Toxicology and Applied Pharmacology (2018)354 (64–80), (S0041008X17304945), (10.1016/j.taap.2017.12.013))

Delp, J., Gutbier, S., Cerff, M., Zasada, C., Niedenführ, S., Zhao, L., Smirnova, L., Hartung, T., Borlinghaus, H., Schreiber, F., Bergemann, J., Gätgens, J., Beyss, M., Azzouzi, S., Waldmann, T., Kempa, S., Nöh, K. & Leist, M., Jun 1 2019, In : Toxicology and Applied Pharmacology. 372, 1 p.

Research output: Contribution to journalComment/debate

Organized Financing
European Union
Toxicology
Neurons
Emotions

Long-term effects of chromium on morphological and immunological parameters of Wistar rats

Karaulov, A. V., Renieri, E. A., Smolyagin, A. I., Mikhaylova, I. V., Stadnikov, A. A., Begun, D. N., Tsarouhas, K., Buha Djordjevic, A., Hartung, T. & Tsatsakis, A., Nov 1 2019, In : Food and Chemical Toxicology. 133, 110748.

Research output: Contribution to journalArticle

Chromium
chromium
long term effects
Wistar Rats
Rats
Quantitative Structure-Activity Relationship
Artificial Intelligence
Artificial intelligence
Big data

Nonanimal Models for Acute Toxicity Evaluations: Applying Data-Driven Profiling and Read-Across

Russo, D. P., Strickland, J., Karmaus, A. L., Wang, W., Shende, S., Hartung, T., Aleksunes, L. M. & Zhu, H., Apr 1 2019, In : Environmental health perspectives. 127, 4, 1 p.

Research output: Contribution to journalArticle

Open Access
Biological Assay
Chemical Models
Toxicology
Cluster Analysis
Animal Models

Optimizing drug discovery by investigative toxicology: Current and future trends

Beilmann, M., Boonen, H., Czich, A., Dear, G., Hewitt, P., Mow, T., Newham, P., Oinonen, T., Pognan, F., Roth, A., Valentin, J. P., Van Goethem, F., Weaver, R. J., Birk, B., Boyer, S., Caloni, F., Chen, A. E., Corvi, R., Cronin, M. T. D., Daneshian, M. & 14 others, Ewart, L. C., FitzGerald, R. E., Hamilton, G. A., Hartung, T., Kangas, J. D., Kramer, N. I., Leist, M., Marx, U., Polak, S., Rovida, C., Testai, E., Van de Water, B., Vulto, P. & Steger-Hartmann, T., Jan 1 2019, In : ALTEX. 36, 2, p. 289-313 25 p.

Research output: Contribution to journalArticle

Open Access
Drug Discovery
Toxicology
Drug Industry
Animal Testing Alternatives
Safety

Predicting toxicity of chemicals: software beats animal testing

Hartung, T., Jul 1 2019, In : EFSA Journal. 17, S1, e170710.

Research output: Contribution to journalArticle

Open Access
Software
Natural Language Processing
Databases
toxicity
reproducibility

Suitability of 3D human brain spheroid models to distinguish toxic effects of gold and poly-lactic acid nanoparticles to assess biocompatibility for brain drug delivery

Leite, P. E. C., Pereira, M. R., Harris, G., Pamies, D., Dos Santos, L. M. G., Granjeiro, J. M., Hogberg, H., Hartung, T. & Smirnova, L., Jun 3 2019, In : Particle and Fibre Toxicology. 16, 1, 22.

Research output: Contribution to journalArticle

Open Access
Brain models
Poisons
Drug delivery
Biocompatibility
Gold

Template for the description of cell-based toxicological test methods to allow evaluation and regulatory use of the data

Krebs, A., Waldmann, T., Wilks, M. F., Van Vugt-Lussenburg, B. M. A., Van der Burg, B., Terron, A., Steger-Hartmann, T., Ruegg, J., Rovida, C., Pedersen, E., Pallocca, G., Luijten, M., Leite, S. B., Kustermann, S., Kamp, H., Hoeng, J., Hewitt, P., Herzler, M., Hengstler, J. G., Heinonen, T. & 16 others, Hartung, T., Hardy, B., Gantner, F., Fritsche, E., Fant, K., Ezendam, J., Exner, T., Dunkern, T., Dietrich, D. R., Coecke, S., Busquet, F., Braeuning, A., Bondarenko, O., Bennekou, S. H., Beilmann, M. & Leist, M., Jan 1 2019, In : ALTEX. 36, 4, p. 682-699 18 p.

Research output: Contribution to journalArticle

Open Access
Toxicology
Toxicity Tests
Agrochemicals
Pharmacopoeias
Documentation

The effect of chronic vitamin deficiency and long term very low dose exposure to 6 pesticides mixture on neurological outcomes – A real-life risk simulation approach

Tsatsakis, A., Tyshko, N. V., Docea, A. O., Shestakova, S. I., Sidorova, Y. S., Petrov, N. A., Zlatian, O., Mach, M., Hartung, T. & Tutelyan, V. A., Oct 15 2019, In : Toxicology Letters. 315, p. 96-106 11 p.

Research output: Contribution to journalArticle

Avitaminosis
Pesticides
Vitamins
Rats
Control Groups

Toward Good In Vitro Reporting Standards

Hartung, T., De Vries, R., Hoffmann, S., Hogberg, H., Smirnova, L., Tsaioun, K., Whaley, P. & Leist, M., Jan 1 2019, In : Altex. 36, 1, p. 3-17 15 p.

Research output: Contribution to journalArticle

Data Display
Peer Review
Biological Science Disciplines
Information Storage and Retrieval
Artificial Intelligence

Towards quality assurance and quality control in untargeted metabolomics studies

Beger, R. D., Dunn, W. B., Bandukwala, A., Bethan, B., Broadhurst, D., Clish, C. B., Dasari, S., Derr, L., Evans, A., Fischer, S., Flynn, T., Hartung, T., Herrington, D., Higashi, R., Hsu, P. C., Jones, C., Kachman, M., Karuso, H., Kruppa, G., Lippa, K. & 18 others, Maruvada, P., Mosley, J., Ntai, I., O’Donovan, C., Playdon, M., Raftery, D., Shaughnessy, D., Souza, A., Spaeder, T., Spalholz, B., Tayyari, F., Ubhi, B., Verma, M., Walk, T., Wilson, I., Witkin, K., Bearden, D. W. & Zanetti, K. A., Jan 1 2019, In : Metabolomics. 15, 1, 4.

Research output: Contribution to journalArticle

Metabolomics
Quality assurance
Quality Control
Quality control
Social Planning

Toxicity testing in the 21st century: progress in the past decade and future perspectives

Krewski, D., Andersen, M. E., Tyshenko, M. G., Krishnan, K., Hartung, T., Boekelheide, K., Wambaugh, J. F., Jones, D., Whelan, M., Thomas, R., Yauk, C., Barton-Maclaren, T. & Cote, I., Jan 1 2019, (Accepted/In press) In : Archives of Toxicology.

Research output: Contribution to journalReview article

Open Access
Toxicity
United States Government Agencies
Testing
Risk assessment
Environmental Health

Uncovering the Role of N-Acetyl-Aspartyl-Glutamate as a Glutamate Reservoir in Cancer

Nguyen, T., Kirsch, B. J., Asaka, R., Nabi, K., Quinones, A., Tan, J., Antonio, M. J., Camelo, F., Li, T., Nguyen, S., Hoang, G., Nguyen, K., Udupa, S., Sazeides, C., Shen, Y. A., Elgogary, A., Reyes, J., Zhao, L., Kleensang, A., Chaichana, K. L. & 7 others, Hartung, T., Betenbaugh, M. J., Marie, S. K., Jung, J. G., Wang, T-L., Gabrielson, E. & Le Thi, Q. H., Apr 9 2019, In : Cell Reports. 27, 2, p. 491-501.e6

Research output: Contribution to journalArticle

Open Access
Glutamic Acid
Glutaminase
Neoplasms
Enzymes
N-acetyl-1-aspartylglutamic acid
2018

3S - Systematic, systemic, and systems biology and toxicology

Smirnova, L., Kleinstreuer, N., Corvi, R., Levchenko, A., Fitzpatrick, S. C. & Hartung, T., Jan 1 2018, In : Altex. 35, 2, p. 139-162 24 p.

Research output: Contribution to journalArticle

Systems Biology
Toxicology
Bioengineering
Poisons
Computer Simulation

Advanced Good Cell Culture Practice for human primary, stem cell-derived and organoid models as well as microphysiological systems

Pamies, D., Bal-Price, A., Chesné, C., Coecke, S., Dinnyes, A., Eskes, C., Grillari, R., Gstraunthaler, G., Hartung, T., Jennings, P., Leist, M., Martin, U., Passier, R., Schwamborn, J. C., Stacey, G. N., Ellinger-Ziegelbauer, H. & Daneshian, M., Jan 1 2018, In : Altex. 35, 3, p. 353-378 26 p.

Research output: Contribution to journalArticle

Organoids
Stem Cells
Cell Culture Techniques
Technology
Induced Pluripotent Stem Cells

Animal testing and its alternatives - the most important omics is economics

Meigs, L., Smirnova, L., Rovida, C., Leist, M. & Hartung, T., Jan 1 2018, In : Altex. 35, 3, p. 275-305 31 p.

Research output: Contribution to journalArticle

Animal Testing Alternatives
Economics
Industry
Animal Welfare
Contracts

A Perspective and a New Integrated Computational Strategy for Skin Sensitization Assessment

Alves, V. M., Capuzzi, S. J., Braga, R. C., Borba, J. V. B., Silva, A. C., Luechtefeld, T., Hartung, T., Andrade, C. H., Muratov, E. N. & Tropsha, A., Mar 5 2018, In : ACS Sustainable Chemistry and Engineering. 6, 3, p. 2845-2859 15 p.

Research output: Contribution to journalReview article

skin
Skin
Animals
animal
Testing

Big-data and machine learning to revamp computational toxicology and its use in risk assessment

Luechtefeld, T., Rowlands, C. & Hartung, T., Jan 1 2018, In : Toxicology Research. 7, 5, p. 732-744 13 p.

Research output: Contribution to journalArticle

Risk assessment
Toxicology
Learning systems
Databases
Benchmarking

Green Toxicology-know early about and avoid toxic product liabilities

Maertens, A. & Hartung, T., Feb 1 2018, In : Toxicological Sciences. 161, 2, p. 285-289 5 p., kfx243.

Research output: Contribution to journalEditorial

Product liability
Poisons
Animal Testing Alternatives
Toxicology
Animals

Induction of IL-10-balanced immune profiles following exposure to LTA from Staphylococcus epidermidis

Volz, T., Kaesler, S., Draing, C., Hartung, T., Röcken, M., Skabytska, Y. & Biedermann, T., Apr 1 2018, In : Experimental Dermatology. 27, 4, p. 318-326 9 p.

Research output: Contribution to journalArticle

Interleukin-10
Dendritic Cells
Atopic Dermatitis
Interleukin-4
T-cells

Machine learning of toxicological big data enables read-across structure activity relationships (RASAR) outperforming animal test reproducibility

Luechtefeld, T., Marsh, D., Rowlands, C. & Hartung, T., Jan 1 2018, In : Toxicological Sciences. 165, 1, p. 198-212 15 p.

Research output: Contribution to journalArticle

Structure-Activity Relationship
Toxicology
Health hazards
Learning systems
Hazards

Perspectives on in vitro to in vivo extrapolations

Hartung, T., Dec 1 2018, In : Applied In Vitro Toxicology. 4, 4, p. 305-316 12 p.

Research output: Contribution to journalReview article

Extrapolation
Toxicity
Testing
Toxicology
Animal Testing Alternatives

Rebooting the generally recognized as safe (GRAS) approach for food additive safety in the US

Hartung, T., Jan 1 2018, In : Altex. 35, 1, p. 3-25 23 p.

Research output: Contribution to journalArticle

Food Additives
Food Safety
United States Food and Drug Administration
Food
Safety

Regulatory acceptance of read-across

Chesnut, M., Yamada, T., Adams, T., Knight, D., Kleinstreuer, N., Kass, G., Luechtefeld, T. & Hartung, T., Jan 1 2018, In : Altex. 35, 3, p. 413-419 7 p.

Research output: Contribution to journalArticle

Animal Testing Alternatives
Chemical Safety
Government Regulation
Hazardous Substances

Rotenone exerts developmental neurotoxicity in a human brain spheroid model

Pamies, D., Block, K., Lau, P., Gribaldo, L., Pardo-Villamizar, C. A., Barreras, P., Smirnova, L., Wiersma, D., Zhao, L., Harris, G., Hartung, T. & Hogberg, H., Jan 1 2018, (Accepted/In press) In : Toxicology and Applied Pharmacology.

Research output: Contribution to journalArticle

Brain models
Rotenone
2,6-dinitrotoluene
Induced Pluripotent Stem Cells
Brain

Stage-specific metabolic features of differentiating neurons: Implications for toxicant sensitivity

Delp, J., Gutbier, S., Cerff, M., Zasada, C., Niedenführ, S., Zhao, L., Smirnova, L., Hartung, T., Borlinghaus, H., Schreiber, F., Bergemann, J., Gätgens, J., Beyss, M., Azzouzi, S., Waldmann, T., Kempa, S., Nöh, K. & Leist, M., Jan 1 2018, (Accepted/In press) In : Toxicology and Applied Pharmacology.

Research output: Contribution to journalArticle

Neurons
Glutamine
Citric Acid Cycle
Fluxes
Metabolic Flux Analysis

Toxicity, recovery, and resilience in a 3D dopaminergic neuronal in vitro model exposed to rotenone

Harris, G., Eschment, M., Orozco, S. P., McCaffery, J. M., Maclennan, R., Severin, D., Leist, M., Kleensang, A., Pamies, D., Maertens, A., Hogberg, H., Freeman, D., Kirkwood, A., Hartung, T. & Smirnova, L., Jun 28 2018, (Accepted/In press) In : Archives of Toxicology. p. 1-20 20 p.

Research output: Contribution to journalArticle

Rotenone
Toxicity
Recovery
Testing
Adenosine Triphosphate
2017

21st Century Cell Culture for 21st Century Toxicology

Pamies, D. & Hartung, T., Jan 17 2017, In : Chemical Research in Toxicology. 30, 1, p. 43-52 10 p.

Research output: Contribution to journalArticle

Cell culture
Toxicology
Cell Culture Techniques
Technology
Tissue
Assays
Cells
Endpoint Determination
Neurodegenerative diseases
Recovery

A Comprehensive Overview of the Current Status and Application of Predictive ADMET: Introduction and Overview

Hartung, T., Jun 3 2017, Experimental Adme and Toxicology. Elsevier Inc., Vol. 4-8. p. 150-155 6 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Metabolism
Enzyme kinetics
Pharmacokinetics
Physiology
Xenobiotics

Advanced cell techniques to study developmental neurobiology and toxicology

Hartung, T., Hogberg, H., Leist, M., Pamies, D. & Smirnova, L., Jan 1 2017, Neural Cell Biology. CRC Press, p. 187-217 31 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Neurobiology
Toxicology
Nervous System
Stem Cells
Neurology

Adverse outcome pathways: opportunities, limitations and open questions

Leist, M., Ghallab, A., Graepel, R., Marchan, R., Hassan, R., Bennekou, S. H., Limonciel, A., Vinken, M., Schildknecht, S., Waldmann, T., Danen, E., van Ravenzwaay, B., Kamp, H., Gardner, I., Godoy, P., Bois, F. Y., Braeuning, A., Reif, R., Oesch, F., Drasdo, D. & 33 others, Höhme, S., Schwarz, M., Hartung, T., Braunbeck, T., Beltman, J., Vrieling, H., Sanz, F., Forsby, A., Gadaleta, D., Fisher, C., Kelm, J., Fluri, D., Ecker, G., Zdrazil, B., Terron, A., Jennings, P., van der Burg, B., Dooley, S., Meijer, A. H., Willighagen, E., Martens, M., Evelo, C., Mombelli, E., Taboureau, O., Mantovani, A., Hardy, B., Koch, B., Escher, S., van Thriel, C., Cadenas, C., Kroese, D., van de Water, B. & Hengstler, J. G., Nov 1 2017, In : Archives of Toxicology. 91, 11, p. 3477-3505 29 p.

Research output: Contribution to journalArticle

Metabolism
Toxicology
Plasticity
History
Weights and Measures

A human brain microphysiological system derived from induced pluripotent stem cells to study neurological diseases and toxicity

Pamies, D., Barreras, P., Block, K., Makri, G., Kumar, A., Wiersma, D., Smirnova, L., Zhang, C., Bressler, J., Christian, K. M., Harris, G., Ming, G. L., Berlinicke, C. J., Kyro, K., Song, H., Pardo, C. A., Hartung, T. & Hogberg, H. T., 2017, In : Altex. 34, 3, p. 362-376 15 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Neuroglia
Brain
Neurons
Myelin Sheath

A primer on systematic reviews in toxicology

Hoffmann, S., de Vries, R. B. M., Stephens, M. L., Beck, N. B., Dirven, H. A. A. M., Fowle, J. R., Goodman, J. E., Hartung, T., Kimber, I., Lalu, M. M., Thayer, K., Whaley, P., Wikoff, D. & Tsaioun, K., May 13 2017, (Accepted/In press) In : Archives of Toxicology. p. 1-25 25 p.

Research output: Contribution to journalArticle

Toxicology
Research
Planning

CIIPro: a new read-across portal to fill data gaps using public large-scale chemical and biological data

Russo, D. P., Kim, M. T., Wang, W., Pinolini, D., Shende, S., Strickland, J., Hartung, T. & Zhu, H., Feb 1 2017, In : Bioinformatics (Oxford, England). 33, 3, p. 464-466 3 p.

Research output: Contribution to journalArticle

Target
Risk assessment
Toxicity
Animals
Risk Assessment

Computational approaches to chemical hazard assessment

Luechtefeld, T. & Hartung, T., Jan 1 2017, In : Altex. 34, 4, p. 459-478 20 p.

Research output: Contribution to journalArticle

Toxicology
Toxicogenetics
Biodiversity
Legislation
Publications

Corrigendum to "The need for strategic development of safety sciences"

Busquet, F. & Hartung, T., Jan 1 2017, In : ALTEX. 34, 2, 1 p.

Research output: Contribution to journalComment/debate

Open Access

Dear readers

ALTEX Editorial Team, Board of ALTEX Edition, Jan 1 2017, In : Altex. 34, 4, p. U2

Research output: Contribution to journalEditorial

Evolution of toxicological science: The need for change

Hartung, T., 2017, In : International Journal of Risk Assessment and Management. 20, 1, p. 21-45 25 p.

Research output: Contribution to journalArticle

Testing
Coverage
Toxicants
Toxicology
Hazard

Food for thought: The need for strategic development of safety sciences

Busquet, F. & Hartung, T., 2017, In : Altex. 34, 1, p. 3-21 19 p.

Research output: Contribution to journalArticle

Safety
Nimodipine
Legislation

Food for Thought .. the First Ten Years

Hartung, T., 2017, In : Altex. 34, 2, p. 187-192 6 p.

Research output: Contribution to journalEditorial

From in vivo to in vitro: The medical device testing paradigm shift

Myers, D. K., Goldberg, A., Poth, A., Wolf, M. F., Carraway, J., McKim, J., Coleman, K. P., Hutchinson, R., Brown, R., Krug, H. F., Bahinski, A. & Hartung, T., Jan 1 2017, In : Altex. 34, 4, p. 479-500 22 p.

Research output: Contribution to journalArticle

Equipment and Supplies
Animal Testing Alternatives
Toxicity Tests
Practice Guidelines
Industry

From the exposome to mechanistic understanding of chemical-induced adverse effects

Escher, B. I., Hackermüller, J., Polte, T., Scholz, S., Aigner, A., Altenburger, R., Böhme, A., Bopp, S. K., Brack, W., Busch, W., Chadeau-Hyam, M., Covaci, A., Eisenträger, A., Galligan, J. J., Garcia-Reyero, N., Hartung, T., Hein, M., Herberth, G., Jahnke, A., Kleinjans, J. & 16 others, Klüver, N., Krauss, M., Lamoree, M., Lehmann, I., Luckenbach, T., Miller, G. W., Müller, A., Phillips, D. H., Reemtsma, T., Rolle-Kampczyk, U., Schüürmann, G., Schwikowski, B., Tan, Y. M., Trump, S., Walter-Rohde, S. & Wambaugh, J. F., Feb 1 2017, In : Environment International. 99, p. 97-106 10 p.

Research output: Contribution to journalReview article

hazard assessment
exposure
effect
chemical
human health

Future Tox III: Bridges for translation

Juberg, D. R., Knudsen, T. B., Sander, M., Beck, N. B., Faustman, E. M., Mendrick, D. L., Fowle, J. R., Hartung, T., Tice, R. R., Lemazurier, E., Becker, R. A., Fitzpatrick, S. C., Daston, G. P., Harrill, A., Hines, R. N., Keller, D. A., Lipscomb, J. C., Watson, D., Bahadori, T. & Crofton, K. M., 2017, In : Toxicological Sciences. 155, 1, p. 22-31 10 p.

Research output: Contribution to journalArticle

Risk assessment
Toxicology
Decision Making
Decision making
Education

Good cell culture practice for stem cells & stem-cell-derived models

Pamies, D., Bal-Price, A., Simeonov, A., Tagle, D., Allen, D., Gerhold, D., Yin, D., Pistollato, F., Inutsuka, T., Sullivan, K., Stacey, G., Salem, H., Leist, M., Daneshian, M., Vemuri, M. C., Mcfarland, R., Coecke, S., Fitzpatrick, S. C., Lakshmipathy, U., Mack, A. & 6 others, Wang, W. B., Yamazaki, D., Sekino, Y., Kanda, Y., Smirnova, L. & Hartung, T., 2017, In : Altex. 34, 1, p. 95-132 38 p.

Research output: Contribution to journalArticle

Stem Cells
Cell Culture Techniques
Biotechnology
Legislation
Practice Guidelines

Good cell culture practices &in vitro toxicology

Eskes, C., Boström, A. C., Bowe, G., Coecke, S., Hartung, T., Hendriks, G., Pamies, D., Piton, A. & Rovida, C., Mar 7 2017, (Accepted/In press) In : Toxicology in Vitro.

Research output: Contribution to journalArticle

Cell culture
Toxicology
Cell Culture Techniques
Testing
Toxicity

Green Toxicology: a strategy for sustainable chemical and material development

Crawford, S. E., Hartung, T., Hollert, H., Mathes, B., van Ravenzwaay, B., Steger-Hartmann, T., Studer, C. & Krug, H. F., Dec 1 2017, In : Environmental Sciences Europe. 29, 1, 16.

Research output: Contribution to journalEditorial

Product development
Testing
Health
Sustainable development
Industry
Mass spectrometry
Metabolomics

Loss of Hepatic Mitochondrial Long-Chain Fatty Acid Oxidation Confers Resistance to Diet-Induced Obesity and Glucose Intolerance

Lee, J., Choi, J., Selen Alpergin, E. S., Zhao, L., Hartung, T., Scafidi, S., Riddle, R. & Wolfgang, M. J., Jul 18 2017, In : Cell Reports. 20, 3, p. 655-667 13 p.

Research output: Contribution to journalArticle

Glucose Intolerance
Oxidation resistance
Nutrition
Fatty Acids
Obesity