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2020

Atypical immune response to Epstein-Barr virus in major depressive disorder

Jones-Brando, L., Dickerson, F., Ford, G., Stallings, C., Origoni, A., Katsafanas, E., Sweeney, K., Squire, A., Khushalani, S. & Yolken, R., Mar 1 2020, In : Journal of Affective Disorders. 264, p. 221-226 6 p.

Research output: Contribution to journalArticle

Major Depressive Disorder
Human Herpesvirus 4
Virion
Nuclear Antigens
Epstein-Barr Virus Infections

Robust kernel association testing (RobKAT)

Martinez, K., Maity, A., Yolken, R. H., Sullivan, P. F. & Tzeng, J. Y., Jan 1 2020, (Accepted/In press) In : Genetic epidemiology.

Research output: Contribution to journalArticle

Major Histocompatibility Complex
Least-Squares Analysis
Single Nucleotide Polymorphism
Clinical Trials
Herpesviridae
2019

A longitudinal study of the association between persistent pathogens and incident depression among older U.S. Latinos

Simanek, A. M., Zheng, C., Yolken, R. H., Haan, M. & Aiello, A. E., May 1 2019, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 74, 5, p. 634-641 8 p.

Research output: Contribution to journalArticle

Open Access
Hispanic Americans
Longitudinal Studies
Depression
Cytomegalovirus
C-Reactive Protein

An Exploratory Examination of Neonatal Cytokines and Chemokines as Predictors of Autism Risk: The Early Markers for Autism Study

Heuer, L. S., Croen, L. A., Jones, K. L., Yoshida, C. K., Hansen, R. L., Yolken, R. H., Zerbo, O., DeLorenze, G., Kharrazi, M., Ashwood, P. & Van de Water, J., Jan 1 2019, In : Biological psychiatry.

Research output: Contribution to journalArticle

Autistic Disorder
Chemokines
Cytokines
Biomarkers
Population Control

Association of Cytomegalovirus and Toxoplasma gondii Antibody Titers with Bipolar Disorder

Frye, M. A., Coombes, B. J., McElroy, S. L., Brando, L. V., Bond, D. J., Veldic, M., Romo-Nava, F., Bobo, W. V., Singh, B., Colby, C., Skime, M. K., Biernacka, J. M. & Yolken, R. H., Jan 1 2019, (Accepted/In press) In : JAMA psychiatry.

Research output: Contribution to journalArticle

Toxoplasma
Cytomegalovirus
Bipolar Disorder
Antibodies
Psychotic Disorders

Association of Early-Life Stress with Cytomegalovirus Infection in Adults with Major Depressive Disorder

Ford, B. N., Yolken, R. H., Aupperle, R. L., Teague, T. K., Irwin, M. R., Paulus, M. P. & Savitz, J., Jan 1 2019, In : JAMA psychiatry.

Research output: Contribution to journalLetter

Major Depressive Disorder
Cytomegalovirus Infections
Psychological Stress
Toxoplasma
Human Herpesvirus 1
Depressive Disorder
Anxiety Disorders
Cytomegalovirus

Cat ownership in childhood and development of schizophrenia

Palomäki, J., Koskela, J., Suvisaari, J., Yolken, R. H., Torrey, F. & Veijola, J., Apr 1 2019, In : Schizophrenia Research. 206, p. 444-445 2 p.

Research output: Contribution to journalLetter

Childhood Schizophrenia
Ownership
Cats
Open Access
Psychotic Disorders
Psychiatry
Cohort Studies

Correction to: The One Health Approach to Toxoplasmosis: Epidemiology, Control, and Prevention Strategies (EcoHealth, (2019), 10.1007/s10393-019-01405-7)

Aguirre, A. A., Longcore, T., Barbieri, M., Dabritz, H., Hill, D., Klein, P. N., Lepczyk, C., Lilly, E. L., McLeod, R., Milcarsky, J., Murphy, C. E., Su, C., VanWormer, E., Yolken, R. H. & Sizemore, G. C., Jan 1 2019, In : EcoHealth.

Research output: Contribution to journalComment/debate

Open Access
Toxoplasmosis
epidemiology
Internet
Epidemiology
Global Health

Exposure to household pet cats and dogs in childhood and risk of subsequent diagnosis of schizophrenia or bipolar disorder

Yolken, R., Stallings, C., Origoni, A., Katsafanas, E., Sweeney, K., Squire, A. & Dickerson, F., Jan 1 2019, In : PloS one. 14, 12, e0225320.

Research output: Contribution to journalArticle

Open Access
Pets
Bipolar Disorder
childhood
pets
households

Genome-wide association study in two populations to determine genetic variants associated with Toxoplasma gondii infection and relationship to schizophrenia risk

Wang, A. W., Avramopoulos, D., Lori, A., Mulle, J., Conneely, K., Powers, A., Duncan, E., Almli, L., Massa, N., McGrath, J., Schwartz, A. C., Goes, F. S., Weng, L., Wang, R., Yolken, R. H., Ruczinski, I., Gillespie, C. F., Jovanovic, T., Ressler, K., Pulver, A. E. & 1 others, Pearce, B. D., Jun 8 2019, In : Progress in Neuro-Psychopharmacology and Biological Psychiatry. 92, p. 133-147 15 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Toxoplasmosis
Schizophrenia
Toxoplasma
Chitinases

Herpes Simplex Virus Type 1 infection is associated with suicidal behavior and first registered psychiatric diagnosis in a healthy population

Nissen, J., Trabjerg, B., Pedersen, M. G., Banasik, K., Pedersen, O. B., Sørensen, E., Nielsen, K. R., Erikstrup, C., Petersen, M. S., Paarup, H. M., Bruun-Rasmussen, P., Westergaard, D., Hansen, T. F., Pedersen, C. B., Werge, T., Torrey, F., Hjalgrim, H., Mortensen, P. B., Yolken, R. H., Brunak, S. & 2 others, Ullum, H. & Burgdorf, K. S., Oct 1 2019, In : Psychoneuroendocrinology. 108, p. 150-154 5 p.

Research output: Contribution to journalArticle

Open Access
Human Herpesvirus 1
Mental Disorders
Psychiatry
Infection
C-Reactive Protein

Infection with Herpes Simplex virus type 1 (HSV-1) and sleep: The dog that did not bark

Meshreky, K. M., Wood, J., Chowdari, K. V., Hall, M. H., Wilckens, K. A., Yolken, R. H., Buysse, D. J. & Nimgaonkar, V. L., Oct 1 2019, In : Psychiatry research. 280, 112502.

Research output: Contribution to journalArticle

Human Herpesvirus 1
Sleep
Dogs
Infection
Sleep Initiation and Maintenance Disorders

Large-scale study of Toxoplasma and Cytomegalovirus shows an association between infection and serious psychiatric disorders

Burgdorf, K. S., Trabjerg, B. B., Pedersen, M. G., Nissen, J., Banasik, K., Pedersen, O. B., Sørensen, E., Nielsen, K. R., Larsen, M. H., Erikstrup, C., Bruun-Rasmussen, P., Westergaard, D., Thørner, L. W., Hjalgrim, H., Paarup, H. M., Brunak, S., Pedersen, C. B., Torrey, E. F., Werge, T., Mortensen, P. B. & 2 others, Yolken, R. H. & Ullum, H., Jan 1 2019, In : Brain, Behavior, and Immunity.

Research output: Contribution to journalArticle

Toxoplasma
Cytomegalovirus
Psychiatry
Confidence Intervals
Infection

NIMH Drug Trials for Schizophrenia

Torrey, E. F., Yolken, R. H. & Lamb, H. R., Jan 15 2019, In : The Journal of clinical psychiatry. 1

Research output: Contribution to journalArticle

National Institute of Mental Health (U.S.)
Schizophrenia
Pharmaceutical Preparations

Nitrated meat products are associated with suicide behavior in psychiatric patients

Dickerson, F., Stallings, C., Origoni, A., Katsafanas, E., Sweeney, K., Khushalani, S. & Yolken, R. H., May 1 2019, In : Psychiatry research. 275, p. 283-286 4 p.

Research output: Contribution to journalArticle

Meat Products
Suicide
Psychiatry
History
Major Depressive Disorder
Complement Activation
Toxoplasma
Microglia
Brain
Infection

Protein intake is associated with cognitive functioning in individuals with psychiatric disorders

Dickerson, F., Gennusa, J. V., Stallings, C., Origoni, A., Katsafanas, E., Sweeney, K., Campbell, W. W. & Yolken, R., Jan 1 2019, (Accepted/In press) In : Psychiatry research. 112700.

Research output: Contribution to journalArticle

Bipolar Disorder
Psychiatry
Schizophrenia
Food
Proteins

Randomized controlled trial of adjunctive Valproate for cognitive remediation in early course schizophrenia

Ibrahim, I., Tobar, S., Fathi, W., ElSayed, H., Yassein, A., Eissa, A., Elsheshtawy, E., Elboraei, H., Shahda, M., Elwasify, M., Ibrahim, A., Chen, K., Wood, J., Dickerson, F., Yolken, R. H., El Chennawi, F., Gur, R., Gur, R., El Bahaey, W., Nimgaonkar, V. & 1 others, Mansour, H., Nov 1 2019, In : Journal of Psychiatric Research. 118, p. 66-72 7 p.

Research output: Contribution to journalArticle

Valproic Acid
Schizophrenia
Randomized Controlled Trials
Placebos
Cognition

Schizophrenia as a pseudogenetic disease: A call for more gene-environmental studies

Torrey, E. F. & Yolken, R. H., Aug 1 2019, In : Psychiatry research. 278, p. 146-150 5 p.

Research output: Contribution to journalArticle

Schizophrenia
Twin Studies
Genes
Genetic Research
Inborn Genetic Diseases

Schizophrenia is Associated With an Aberrant Immune Response to Epstein-Barr Virus

Dickerson, F., Brando, L. V., Ford, G., Genovese, G., Stallings, C., Origoni, A., O'Dushlaine, C., Katsafanas, E., Sweeney, K., Khushalani, S. & Yolken, R. H., Sep 11 2019, In : Schizophrenia bulletin. 45, 5, p. 1112-1119 8 p.

Research output: Contribution to journalArticle

Human Herpesvirus 4
Schizophrenia
Antibodies
Virion
Epstein-Barr Virus Nuclear Antigens

Stratification and prediction of remission in first-episode psychosis patients: the OPTiMiSE cohort study

the OPTiMiSE Study Group, Jan 1 2019, In : Translational Psychiatry. 9, 1, 20.

Research output: Contribution to journalArticle

Psychotic Disorders
Cohort Studies
Antipsychotic Agents
Serum
Clinical Decision Support Systems

The lack of association between herpes simplex virus 1 or Toxoplasma gondii infection and cognitive decline in the general population: An 11-year follow-up study

Torniainen-Holm, M., Suvisaari, J., Lindgren, M., Härkänen, T., Dickerson, F. & Yolken, R. H., Feb 1 2019, In : Brain, Behavior, and Immunity. 76, p. 159-164 6 p.

Research output: Contribution to journalArticle

Toxoplasmosis
Human Herpesvirus 1
Dementia
Population
Toxoplasma

The One Health Approach to Toxoplasmosis: Epidemiology, Control, and Prevention Strategies

Aguirre, A. A., Longcore, T., Barbieri, M., Dabritz, H., Hill, D., Klein, P. N., Lepczyk, C., Lilly, E. L., McLeod, R., Milcarsky, J., Murphy, C. E., Su, C., VanWormer, E., Yolken, R. H. & Sizemore, G. C., Jan 1 2019, In : EcoHealth.

Research output: Contribution to journalReview article

Toxoplasmosis
Toxoplasma
epidemiology
Epidemiology
Protozoan Infections

Transcription of human endogenous retroviruses in human brain by RNA-seq analysis

Li, F., Sabunciyan, S., Yolken, R. H., Lee, D., Kim, S. & Karlsson, H., Jan 1 2019, In : PLoS One. 14, 1, e0207353.

Research output: Contribution to journalArticle

Retroviridae
Endogenous Retroviruses
Transcription
Brain
transcription (genetics)
2018

AAH2 gene is not required for dopamine-dependent neurochemical and behavioral abnormalities produced by Toxoplasma infection in mouse

McFarland, R., Wang, Z. T., Jouroukhin, Y., Li, Y., Mychko, O., Coppens, I., Xiao, J-C., Brando, L. V., Yolken, R. H., Sibley, L. D. & Pletnikov, M., Jul 16 2018, In : Behavioural Brain Research. 347, p. 193-200 8 p.

Research output: Contribution to journalArticle

Toxoplasma
Dopamine
Toxoplasmosis
Infection
Genes

Adjunctive probiotic microorganisms to prevent rehospitalization in patients with acute mania: A randomized controlled trial

Dickerson, F., Adamos, M., Katsafanas, E., Khushalani, S., Origoni, A., Savage, C., Schweinfurth, L., Stallings, C., Sweeney, K., Goga, J. & Yolken, R. H., Jan 1 2018, (Accepted/In press) In : Bipolar Disorders.

Research output: Contribution to journalArticle

Probiotics
Bipolar Disorder
Randomized Controlled Trials
Inflammation
Placebos

Aggression, impulsivity and inflammatory markers as risk factors for suicidal behavior

Coryell, W., Wilcox, H., Evans, S. J., Pandey, G. N., Brando, L. V., Dickerson, F. & Yolken, R. H., Nov 1 2018, In : Journal of Psychiatric Research. 106, p. 38-42 5 p.

Research output: Contribution to journalArticle

Impulsive Behavior
Aggression
Suicide
Interleukin-1
History

A Nationwide Study in Denmark of the Association between Treated Infections and the Subsequent Risk of Treated Mental Disorders in Children and Adolescents

Köhler-Forsberg, O., Petersen, L., Gasse, C., Mortensen, P. B., Dalsgaard, S., Yolken, R. H., Mors, O. & Benros, M. E., Jan 1 2018, (Accepted/In press) In : JAMA Psychiatry.

Research output: Contribution to journalArticle

Denmark
Mental Disorders
Infection
Prescriptions
Anti-Infective Agents

A New T. gondii Mouse Model of Gene-Environment Interaction Relevant to Psychiatric Disease

Kannan, G., Prandovszky, E., Severance, E. G., Yolken, R. H. & Pletnikov, M., Jan 1 2018, In : Scientifica. 2018, 7590958.

Research output: Contribution to journalArticle

Gene-Environment Interaction
genotype-environment interaction
Toxoplasma
Toxoplasma gondii
Psychiatry

Association of cytomegalovirus and Epstein-Barr virus with cognitive functioning and risk of dementia in the general population: 11-year follow-up study

Torniainen-Holm, M., Suvisaari, J., Lindgren, M., Härkänen, T., Dickerson, F. & Yolken, R. H., Jan 1 2018, (Accepted/In press) In : Brain, Behavior, and Immunity.

Research output: Contribution to journalArticle

Cytomegalovirus
Human Herpesvirus 4
Dementia
Population
Seroepidemiologic Studies

Autoimmune phenotypes in schizophrenia reveal novel treatment targets

Severance, E. G., Dickerson, F. B. & Yolken, R. H., Jan 1 2018, (Accepted/In press) In : Pharmacology and Therapeutics.

Research output: Contribution to journalArticle

Schizophrenia
Phenotype
Genetic Templates
Antipsychotic Agents
Dopamine
Toxoplasmosis
N-Methyl-D-Aspartate Receptors
Autoantibodies
Cysts
Toxoplasma

Cigarette smoking by patients with serious mental illness, 1999-2016: An increasing disparity

Dickerson, F., Schroeder, J., Katsafanas, E., Khushalani, S., Origoni, A. E., Savage, C., Schweinfurth, L., Stallings, C. R., Sweeney, K. & Yolken, R. H., Feb 1 2018, In : Psychiatric Services. 69, 2, p. 147-153 7 p.

Research output: Contribution to journalArticle

Smoking
Bipolar Disorder
Tobacco Products
Schizophrenia
Psychiatry

Clinical and serological predictors of suicide in schizophrenia and major mood disorders

Dickerson, F., Origoni, A., Schweinfurth, L. A. B., Stallings, C., Savage, C. L. G., Sweeney, K., Katsafanas, E., Wilcox, H., Khushalani, S. & Yolken, R. H., Jan 1 2018, In : Journal of Nervous and Mental Disease. 206, 3, p. 173-178 6 p.

Research output: Contribution to journalArticle

Mood Disorders
Suicide
Schizophrenia
Cytomegalovirus
Antibodies

Cross-genetic determination of maternal and neonatal immune mediators during pregnancy

Traglia, M., Croen, L. A., Jones, K. L., Heuer, L. S., Yolken, R. H., Kharrazi, M., DeLorenze, G. N., Ashwood, P., Van de Water, J. & Weiss, L. A., Aug 22 2018, In : Genome Medicine. 10, 1, 67.

Research output: Contribution to journalArticle

Genetic Crosses
Mothers
Pregnancy
Immune System
Chemokines

Deciphering microbiome and neuroactive immune gene interactions in schizophrenia

Severance, E. G. & Yolken, R. H., Jan 1 2018, (Accepted/In press) In : Neurobiology of Disease.

Research output: Contribution to journalArticle

Microbiota
Schizophrenia
Major Histocompatibility Complex
Dysbiosis
Genes

DISC1 regulates lactate metabolism in astrocytes: Implications for psychiatric disorders

Jouroukhin, Y., Kageyama, Y., Misheneva, V., Shevelkin, A., Andrabi, S., Prandovszky, E., Yolken, R. H., Dawson, V., Dawson, T. M., Aja, S. M., Sesaki, H. & Pletnikov, M., Dec 1 2018, In : Translational Psychiatry. 8, 1, 76.

Research output: Contribution to journalArticle

Astrocytes
Psychiatry
Lactic Acid
Schizophrenia
Glucose

Generation of three-dimensional human neuronal cultures: Application to modeling CNS viral infections

D'Aiuto, L., Naciri, J., Radio, N., Tekur, S., Clayton, D., Apodaca, G., Di Maio, R., Zhi, Y., Dimitrion, P., Piazza, P., Demers, M., Wood, J., Chu, C., Callio, J., McClain, L., Yolken, R. H., McNulty, J., Kinchington, P., Bloom, D. & Nimgaonkar, V., May 11 2018, In : Stem Cell Research and Therapy. 9, 1, 134.

Research output: Contribution to journalArticle

Central Nervous System Viral Diseases
Induced Pluripotent Stem Cells
Preclinical Drug Evaluations
Acyclovir
Neurology

Herpes simplex virus 1 infection and valacyclovir treatment in schizophrenia: Results from the VISTA study

Breier, A., Buchanan, R. W., D'Souza, D., Nuechterlein, K., Marder, S., Dunn, W., Preskorn, S., Macaluso, M., Wurfel, B., Maguire, G., Kakar, R., Highum, D., Hoffmeyer, D., Coskinas, E., Litman, R., Vohs, J. L., Radnovich, A., Francis, M. M., Metzler, E., Visco, A. & 5 others, Mehdiyoun, N., Yang, Z., Zhang, Y., Yolken, R. H. & Dickerson, F. B., Jan 1 2018, (Accepted/In press) In : Schizophrenia Research.

Research output: Contribution to journalArticle

valacyclovir
Human Herpesvirus 1
Virus Diseases
Schizophrenia
Therapeutics

HLA typing using genome wide data reveals susceptibility types for infections in a psychiatric disease enriched sample

Parks, S., Avramopoulos, D., Mulle, J., McGrath, J., Wang, R., Goes, F. S., Conneely, K., Ruczinski, I., Yolken, R. H., Pulver, A. E. & Pearce, B. D., Jan 1 2018, (Accepted/In press) In : Brain, Behavior, and Immunity.

Research output: Contribution to journalArticle

Histocompatibility Testing
Psychiatry
Genome
Schizophrenia
Infection

Host–parasite interaction associated with major mental illness

Kano, S., Hodgkinson, C. A., Brando, L. V., Eastwood, S., Ishizuka, K., Niwa, M., Choi, E. Y., Chang, D. J., Chen, Y., Velivela, S. D., Leister, F., Wood, J., Chowdari, K., Ducci, F., Caycedo, D. A., Heinz, E., Newman, E. R., Cascella, N., Mortensen, P. B., Zandi, P. P. & 6 others, Dickerson, F., Nimgaonkar, V., Goldman, D., Harrison, P. J., Yolken, R. H. & Sawa, A., Jan 1 2018, (Accepted/In press) In : Molecular Psychiatry.

Research output: Contribution to journalArticle

Toxoplasmosis
Toxoplasma
Schizophrenia
Activating Transcription Factor 4
Gene Expression

Immunoglobulin sub-class distribution in bipolar disorder and schizophrenia: Potential relationship with latent Toxoplasma Gondii infection

Hamdani, N., Bengoufa, D., Godin, O., Doukhan, R., Le Guen, E., Daban-Huard, C., Bennabi, M., Delavest, M., Lépine, J. P., Boukouaci, W., Laouamri, H., Houenou, J., Jamain, S., Richard, J. R., Lecorvosier, P., Yolken, R. H., Rajagopal, K., Leboyer, M. & Tamouza, R., Jul 27 2018, In : BMC Psychiatry. 18, 1, 239.

Research output: Contribution to journalArticle

Immunoglobulin Isotypes
Toxoplasmosis
Bipolar Disorder
Schizophrenia
Immunoglobulin G

Inflammatory biomarkers in psychosis and clinical high risk populations

Delaney, S., Fallon, B., Alaedini, A., Yolken, R. H., Indart, A., Feng, T., Wang, Y. & Javitt, D., Jan 1 2018, (Accepted/In press) In : Schizophrenia Research.

Research output: Contribution to journalArticle

Psychotic Disorders
Interleukin-6
Biomarkers
Lipopolysaccharides
Population

Joint evaluation of serum C-Reactive Protein levels and polygenic risk scores as risk factors for schizophrenia

Nimgaonkar, V. L., Dickerson, F., Pouget, J. G., Chowdari, K., O'Dushlaine, C., Wood, J., Klei, L., Devlin, B. & Yolken, R. H., Mar 1 2018, In : Psychiatry Research. 261, p. 148-153 6 p.

Research output: Contribution to journalArticle

C-Reactive Protein
Blood Proteins
Schizophrenia
Odds Ratio
Confidence Intervals

Longitudinal serological measures of common infection in the Avon Longitudinal study of parents and children cohort [version 2; referees: 2 approved]

Mitchell, R. E., Jones, H. J., Yolken, R. H., Ford, G., Brando, L. V., Ring, S. M., Groom, A., Fitzgibbon, S., Smith, G. D. & Timpson, N. J., Jan 1 2018, In : Wellcome Open Research. 3, 49.

Research output: Contribution to journalComment/debate

Open Access
Viruses
Longitudinal Studies
Parents
Toxoplasma
Caseins

Maternal immune activation: reporting guidelines to improve the rigor, reproducibility, and transparency of the model

Kentner, A. C., Bilbo, S. D., Brown, A. S., Hsiao, E. Y., McAllister, A. K., Meyer, U., Pearce, B. D., Pletnikov, M., Yolken, R. H. & Bauman, M. D., Jan 1 2018, (Accepted/In press) In : Neuropsychopharmacology.

Research output: Contribution to journalArticle

Practice Guidelines
Mothers
Guidelines
Checklist
Animal Models

Monocyte activation detected prior to a diagnosis of schizophrenia in the US Military New Onset Psychosis Project (MNOPP)

Weber, N. S., Gressitt, K. L., Cowan, D. N., Niebuhr, D. W., Yolken, R. H. & Severance, E. G., Jan 1 2018, (Accepted/In press) In : Schizophrenia Research.

Research output: Contribution to journalArticle

Psychotic Disorders
Monocytes
Schizophrenia
C-Reactive Protein
Inflammation

Natural cause mortality in persons with serious mental illness

Dickerson, F., Origoni, A., Schroeder, J., Adamos, M., Katsafanas, E., Khushalani, S., Savage, C. L. G., Schweinfurth, L. A. B., Stallings, C., Sweeney, K. & Yolken, R. H., Jan 1 2018, (Accepted/In press) In : Acta Psychiatrica Scandinavica.

Research output: Contribution to journalArticle

Mortality
Smoking
Human Herpesvirus 4
Widowhood
Divorce