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2019

A generative-predictive framework to capture altered brain activity in fMRI and its association with genetic risk: Application to Schizophrenia

Ghosal, S., Chen, Q., Goldman, A. L., Ulrich, W., Berman, K. F., Weinberger, D. R., Mattay, V. S. & Venkataraman, A., Jan 1 2019, Medical Imaging 2019: Image Processing. Landman, B. A., Angelini, E. D., Angelini, E. D. & Angelini, E. D. (eds.). SPIE, 1094927. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 10949).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

schizophrenia
brain
Brain
Schizophrenia
Magnetic Resonance Imaging

A Genetics Perspective on the Role of the (Neuro)Immune System in Schizophrenia

Birnbaum, R. & Weinberger, D., Jan 1 2019, In : Schizophrenia Research.

Research output: Contribution to journalArticle

Immune System
Schizophrenia
Neuroimaging
Up-Regulation
Developmental Biology

Association of a Schizophrenia-Risk Nonsynonymous Variant with Putamen Volume in Adolescents: A Voxelwise and Genome-Wide Association Study

Luo, Q., Chen, Q., Wang, W., Desrivières, S., Quinlan, E. B., Jia, T., Macare, C., Robert, G. H., Cui, J., Guedj, M., Palaniyappan, L., Kherif, F., Banaschewski, T., Bokde, A. L. W., Büchel, C., Flor, H., Frouin, V., Garavan, H., Gowland, P., Heinz, A. & 24 others, Ittermann, B., Martinot, J. L., Artiges, E., Paillère-Martinot, M. L., Nees, F., Orfanos, D. P., Poustka, L., Fröhner, J. H., Smolka, M. N., Walter, H., Whelan, R., Callicott, J. H., Mattay, V., Pausova, Z., Dartigues, J. F., Tzourio, C., Crivello, F., Berman, K. F., Li, F., Paus, T., Weinberger, D., Murray, R. M., Schumann, G. & Feng, J., Jan 1 2019, (Accepted/In press) In : JAMA psychiatry.

Research output: Contribution to journalArticle

Open Access
Genome-Wide Association Study
Putamen
Schizophrenia
Brain
Siblings

Author Correction: Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function (Nature Communications, (2018), 9, 1, (2098), 10.1038/s41467-018-04362-x)

Davies, G., Lam, M., Harris, S. E., Trampush, J. W., Luciano, M., Hill, W. D., Hagenaars, S. P., Ritchie, S. J., Marioni, R. E., Fawns-Ritchie, C., Liewald, D. C. M., Okely, J. A., Ahola-Olli, A. V., Barnes, C. L. K., Bertram, L., Bis, J. C., Burdick, K. E., Christoforou, A., DeRosse, P., Djurovic, S. & 202 others, Espeseth, T., Giakoumaki, S., Giddaluru, S., Gustavson, D. E., Hayward, C., Hofer, E., Ikram, M. A., Karlsson, R., Knowles, E., Lahti, J., Leber, M., Li, S., Mather, K. A., Melle, I., Morris, D., Oldmeadow, C., Palviainen, T., Payton, A., Pazoki, R., Petrovic, K., Reynolds, C. A., Sargurupremraj, M., Scholz, M., Smith, J. A., Smith, A. V., Terzikhan, N., Thalamuthu, A., Trompet, S., van der Lee, S. J., Ware, E. B., Windham, B. G., Wright, M. J., Yang, J., Yu, J., Ames, D., Amin, N., Amouyel, P., Andreassen, O. A., Armstrong, N. J., Assareh, A. A., Attia, J. R., Attix, D., Avramopoulos, D., Bennett, D. A., Böhmer, A. C., Boyle, P. A., Brodaty, H., Campbell, H., Cannon, T. D., Cirulli, E. T., Congdon, E., Conley, E. D., Corley, J., Cox, S. R., Dale, A. M., Dehghan, A., Dick, D., Dickinson, D., Eriksson, J. G., Evangelou, E., Faul, J. D., Ford, I., Freimer, N. A., Gao, H., Giegling, I., Gillespie, N. A., Gordon, S. D., Gottesman, R. F., Griswold, M. E., Gudnason, V., Harris, T. B., Hartmann, A. M., Hatzimanolis, A., Heiss, G., Holliday, E. G., Joshi, P. K., Kähönen, M., Kardia, S. L. R., Karlsson, I., Kleineidam, L., Knopman, D. S., Kochan, N. A., Konte, B., Kwok, J. B., Le Hellard, S., Lee, T., Lehtimäki, T., Li, S. C., Lill, C. M., Liu, T., Koini, M., London, E., Longstreth, W. T., Lopez, O. L., Loukola, A., Luck, T., Lundervold, A. J., Lundquist, A., Lyytikäinen, L. P., Martin, N. G., Montgomery, G. W., Murray, A. D., Need, A. C., Noordam, R., Nyberg, L., Ollier, W., Papenberg, G., Pattie, A., Polasek, O., Poldrack, R. A., Psaty, B. M., Reppermund, S., Riedel-Heller, S. G., Rose, R. J., Rotter, J. I., Roussos, P., Rovio, S. P., Saba, Y., Sabb, F. W., Sachdev, P. S., Satizabal, C. L., Schmid, M., Scott, R. J., Scult, M. A., Simino, J., Slagboom, P. E., Smyrnis, N., Soumaré, A., Stefanis, N. C., Stott, D. J., Straub, R. E., Sundet, K., Taylor, A. M., Taylor, K. D., Tzoulaki, I., Tzourio, C., Uitterlinden, A., Vitart, V., Voineskos, A. N., Kaprio, J., Wagner, M., Wagner, H., Weinhold, L., Wen, K. H., Widen, E., Yang, Q., Zhao, W., Adams, H. H. H., Arking, D., Bilder, R. M., Bitsios, P., Boerwinkle, E., Chiba-Falek, O., Corvin, A., De Jager, P. L., Debette, S., Donohoe, G., Elliott, P., Fitzpatrick, A. L., Gill, M., Glahn, D. C., Hägg, S., Hansell, N. K., Hariri, A. R., Ikram, M. K., Jukema, J. W., Vuoksimaa, E., Keller, M. C., Kremen, W. S., Launer, L., Lindenberger, U., Palotie, A., Pedersen, N. L., Pendleton, N., Porteous, D. J., Räikkönen, K., Raitakari, O. T., Ramirez, A., Reinvang, I., Rudan, I., Dan Rujescu, R., Schmidt, R., Schmidt, H., Schofield, P. W., Schofield, P. R., Starr, J. M., Steen, V. M., Trollor, J. N., Turner, S. T., Van Duijn, C. M., Villringer, A., Weinberger, D., Weir, D. R., Wilson, J. F., Malhotra, A., McIntosh, A. M., Gale, C. R., Seshadri, S., Mosley, T. H., Bressler, J., Lencz, T. & Deary, I. J., Dec 1 2019, In : Nature communications. 10, 1, 2068.

Research output: Contribution to journalComment/debate

Open Access
document markup languages
HTML
Genetic Loci
loci
lists

Comparison of quantitative trait loci methods: Total expression and allelic imbalance method in brain RNA-seq

The BrainSeq Consortium¶, Jun 1 2019, In : PloS one. 14, 6, e0217765.

Research output: Contribution to journalArticle

Open Access
Allelic Imbalance
Quantitative Trait Loci
quantitative trait loci
Brain
Genes

Comprehensive assessment of multiple biases in small RNA sequencing reveals significant differences in the performance of widely used methods

Wright, C., Rajpurohit, A., Burke, E. E., Williams, C., Collado-Torres, L., Kimos, M., Brandon, N. J., Cross, A. J., Jaffe, A. E., Weinberger, D. R. & Shin, J. H., Jun 21 2019, In : BMC genomics. 20, 1, 513.

Research output: Contribution to journalArticle

Open Access
RNA Sequence Analysis
MicroRNAs
Reverse Transcription
Libraries
Ligation

Divergent neuronal DNA methylation patterns across human cortical development reveal critical periods and a unique role of CpH methylation

Price, A. J., Collado-Torres, L., Ivanov, N. A., Xia, W., Burke, E. E., Shin, J. H., Tao, R., Ma, L., Jia, Y., Hyde, T. M., Kleinman, J. E., Weinberger, D. R. & Jaffe, A. E., Sep 26 2019, In : Genome biology. 20, 1, 196.

Research output: Contribution to journalArticle

Open Access
methylation
Human Development
DNA methylation
DNA Methylation
Methylation

Dysregulated protocadherin-pathway activity as an intrinsic defect in induced pluripotent stem cell–derived cortical interneurons from subjects with schizophrenia

Shao, Z., Noh, H., Bin Kim, W., Ni, P., Nguyen, C., Cote, S. E., Noyes, E., Zhao, J., Parsons, T., Park, J. M., Zheng, K., Park, J. J., Coyle, J. T., Weinberger, D., Straub, R. E., Berman, K. F., Apud, J., Ongur, D., Cohen, B. M., McPhie, D. L. & 17 others, Rapoport, J. L., Perlis, R. H., Lanz, T. A., Xi, H. S., Yin, C., Huang, W., Hirayama, T., Fukuda, E., Yagi, T., Ghosh, S., Eggan, K. C., Kim, H. Y., Eisenberg, L. M., Moghadam, A. A., Stanton, P. K., Cho, J. H. & Chung, S., Feb 1 2019, In : Nature neuroscience. 22, 2, p. 229-242 14 p.

Research output: Contribution to journalArticle

Interneurons
Schizophrenia
GABAergic Neurons
Induced Pluripotent Stem Cells
Prefrontal Cortex

Gene expression imputation across multiple brain regions provides insights into schizophrenia risk

iPSYCH-GEMS Schizophrenia Working Group, CommonMind Consortium & The Schizophrenia Working Group of the PsyUniversity of Copenhagenchiatric Genomics Consortium, Apr 1 2019, In : Nature genetics. 51, 4, p. 659-674 16 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Prefrontal Cortex
Schizophrenia
Tay-Sachs Disease
Gene Expression

Genetic architecture of subcortical brain structures in 38,851 individuals

Satizabal, C. L., Adams, H. H. H., Hibar, D. P., White, C. C., Knol, M. J., Stein, J. L., Scholz, M., Sargurupremraj, M., Jahanshad, N., Roshchupkin, G. V., Smith, A. V., Bis, J. C., Jian, X., Luciano, M., Hofer, E., Teumer, A., van der Lee, S. J., Yang, J., Yanek, L. R., Lee, T. V. & 269 others, Li, S., Hu, Y., Koh, J. Y., Eicher, J. D., Desrivières, S., Arias-Vasquez, A., Chauhan, G., Athanasiu, L., Rentería, M. E., Kim, S., Hoehn, D., Armstrong, N. J., Chen, Q., Holmes, A. J., den Braber, A., Kloszewska, I., Andersson, M., Espeseth, T., Grimm, O., Abramovic, L., Alhusaini, S., Milaneschi, Y., Papmeyer, M., Axelsson, T., Ehrlich, S., Roiz-Santiañez, R., Kraemer, B., Håberg, A. K., Jones, H. J., Pike, G. B., Stein, D. J., Stevens, A., Bralten, J., Vernooij, M. W., Harris, T. B., Filippi, I., Witte, A. V., Guadalupe, T., Wittfeld, K., Mosley, T. H., Becker, J. T., Doan, N. T., Hagenaars, S. P., Saba, Y., Cuellar-Partida, G., Amin, N., Hilal, S., Nho, K., Mirza-Schreiber, N., Arfanakis, K., Becker, D. M., Ames, D., Goldman, A. L., Lee, P. H., Boomsma, D. I., Lovestone, S., Giddaluru, S., Le Hellard, S., Mattheisen, M., Bohlken, M. M., Kasperaviciute, D., Schmaal, L., Lawrie, S. M., Agartz, I., Walton, E., Tordesillas-Gutierrez, D., Davies, G. E., Shin, J., Ipser, J. C., Vinke, L. N., Hoogman, M., Jia, T., Burkhardt, R., Klein, M., Crivello, F., Janowitz, D., Carmichael, O., Haukvik, U. K., Aribisala, B. S., Schmidt, H., Strike, L. T., Cheng, C. Y., Risacher, S. L., Pütz, B., Fleischman, D. A., Assareh, A. A., Mattay, V. S., Buckner, R. L., Mecocci, P., Dale, A. M., Cichon, S., Boks, M. P., Matarin, M., Penninx, B. W. J. H., Calhoun, V. D., Chakravarty, M. M., Marquand, A. F., Macare, C., Kharabian Masouleh, S., Oosterlaan, J., Amouyel, P., Hegenscheid, K., Rotter, J. I., Schork, A. J., Liewald, D. C. M., de Zubicaray, G. I., Wong, T. Y., Shen, L., Sämann, P. G., Brodaty, H., Roffman, J. L., de Geus, E. J. C., Tsolaki, M., Erk, S., van Eijk, K. R., Cavalleri, G. L., van der Wee, N. J. A., McIntosh, A. M., Gollub, R. L., Bulayeva, K. B., Bernard, M., Richards, J. S., Himali, J. J., Loeffler, M., Rommelse, N., Hoffmann, W., Westlye, L. T., Valdés Hernández, M. C., Hansell, N. K., van Erp, T. G. M., Wolf, C., Kwok, J. B. J., Vellas, B., Heinz, A., Olde Loohuis, L. M., Delanty, N., Ho, B. C., Ching, C. R. K., Shumskaya, E., Singh, B., Hofman, A., van der Meer, D., Homuth, G., Psaty, B. M., Bastin, M. E., Montgomery, G. W., Foroud, T. M., Reppermund, S., Hottenga, J. J., Simmons, A., Meyer-Lindenberg, A., Cahn, W., Whelan, C. D., van Donkelaar, M. M. J., Yang, Q., Hosten, N., Green, R. C., Thalamuthu, A., Mohnke, S., Hulshoff Pol, H. E., Lin, H., Jack, C. R., Schofield, P. R., Mühleisen, T. W., Maillard, P., Potkin, S. G., Wen, W., Fletcher, E., Toga, A. W., Gruber, O., Huentelman, M., Davey Smith, G., Launer, L. J., Nyberg, L., Jönsson, E. G., Crespo-Facorro, B., Koen, N., Greve, D. N., Uitterlinden, A. G., Weinberger, D. R., Steen, V. M., Fedko, I. O., Groenewold, N. A., Niessen, W. J., Toro, R., Tzourio, C., Longstreth, W. T., Ikram, M. K., Smoller, J. W., van Tol, M. J., Sussmann, J. E., Paus, T., Lemaître, H., Schroeter, M. L., Mazoyer, B., Andreassen, O. A., Holsboer, F., Depondt, C., Veltman, D. J., Turner, J. A., Pausova, Z., Schumann, G., van Rooij, D., Djurovic, S., Deary, I. J., McMahon, K. L., Müller-Myhsok, B., Brouwer, R. M., Soininen, H., Pandolfo, M., Wassink, T. H., Cheung, J. W., Wolfers, T., Martinot, J. L., Zwiers, M. P., Nauck, M., Melle, I., Martin, N. G., Kanai, R., Westman, E., Kahn, R. S., Sisodiya, S. M., White, T., Saremi, A., van Bokhoven, H., Brunner, H. G., Völzke, H., Wright, M. J., van ‘t Ent, D., Nöthen, M. M., Ophoff, R. A., Buitelaar, J. K., Fernández, G., Sachdev, P. S., Rietschel, M., van Haren, N. E. M., Fisher, S. E., Beiser, A. S., Francks, C., Saykin, A. J., Mather, K. A., Romanczuk-Seiferth, N., Hartman, C. A., DeStefano, A. L., Heslenfeld, D. J., Weiner, M. W., Walter, H., Hoekstra, P. J., Nyquist, P. A., Franke, B., Bennett, D. A., Grabe, H. J., Johnson, A. D., Chen, C., van Duijn, C. M., Lopez, O. L., Fornage, M., Wardlaw, J. M., Schmidt, R., DeCarli, C., De Jager, P. L., Villringer, A., Debette, S., Gudnason, V., Medland, S. E., Shulman, J. M., Thompson, P. M., Seshadri, S. & Ikram, M. A., Nov 1 2019, In : Nature genetics. 51, 11, p. 1624-1636 13 p.

Research output: Contribution to journalArticle

Axonal Transport
Globus Pallidus
Caudate Nucleus
Genome-Wide Association Study
Putamen

Integrated DNA methylation and gene expression profiling across multiple brain regions implicate novel genes in Alzheimer’s disease

Semick, S. A., Bharadwaj, R. A., Collado-Torres, L., Tao, R., Shin, J. H., Deep-Soboslay, A., Weiss, J. R., Weinberger, D., Hyde, T., Kleinman, J., Jaffe, A. & Mattay, V., Jan 1 2019, In : Acta Neuropathologica.

Research output: Contribution to journalArticle

Gene Expression Profiling
DNA Methylation
Alzheimer Disease
Brain
Epigenomics

iPSC-derived homogeneous populations of developing schizophrenia cortical interneurons have compromised mitochondrial function

Ni, P., Noh, H., Park, G. H., Shao, Z., Guan, Y., Park, J. M., Yu, S., Park, J. S., Coyle, J. T., Weinberger, D., Straub, R. E., Cohen, B. M., McPhie, D. L., Yin, C., Huang, W., Kim, H. Y. & Chung, S., Jan 1 2019, In : Molecular psychiatry.

Research output: Contribution to journalArticle

Interneurons
Schizophrenia
Population
Oxidative Phosphorylation
Acetylcarnitine

KCNH2-3.1 mediates aberrant complement activation and impaired hippocampal-medial prefrontal circuitry associated with working memory deficits

Ren, M., Hu, Z., Chen, Q., Jaffe, A., Li, Y., Sadashivaiah, V., Zhu, S., Rajpurohit, N., Heon Shin, J., Xia, W., Jia, Y., Wu, J., Lang Qin, S., Li, X., Zhu, J., Tian, Q., Paredes, D., Zhang, F., Hong Wang, K., Mattay, V. S. & 4 others, Callicott, J. H., Berman, K. F., Weinberger, D. R. & Yang, F., Jan 1 2019, (Accepted/In press) In : Molecular psychiatry.

Research output: Contribution to journalArticle

Complement Activation
Potassium Channels
Memory Disorders
Short-Term Memory
Synapses

Long-read sequencing reveals the complex splicing profile of the psychiatric risk gene CACNA1C in human brain

Clark, M. B., Wrzesinski, T., Garcia, A. B., Hall, N. A. L., Kleinman, J. E., Hyde, T., Weinberger, D. R., Harrison, P. J., Haerty, W. & Tunbridge, E. M., Jan 1 2019, (Accepted/In press) In : Molecular psychiatry.

Research output: Contribution to journalArticle

Psychiatry
Protein Isoforms
Brain
Nanopores
Genes

Neurons with Complex Karyotypes Are Rare in Aged Human Neocortex

Chronister, W. D., Burbulis, I. E., Wierman, M. B., Wolpert, M. J., Haakenson, M. F., Smith, A. C. B., Kleinman, J., Hyde, T., Weinberger, D., Bekiranov, S. & McConnell, M. J., Jan 22 2019, In : Cell Reports. 26, 4, p. 825-835.e7

Research output: Contribution to journalArticle

Neocortex
Karyotype
Neurons
Atlases
Brain

Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways

Lam, M., Hill, W. D., Trampush, J. W., Yu, J., Knowles, E., Davies, G., Stahl, E., Huckins, L., Liewald, D. C., Djurovic, S., Melle, I., Sundet, K., Christoforou, A., Reinvang, I., DeRosse, P., Lundervold, A. J., Steen, V. M., Espeseth, T., Räikkönen, K., Widen, E. & 48 others, Palotie, A., Eriksson, J. G., Giegling, I., Konte, B., Hartmann, A. M., Roussos, P., Giakoumaki, S., Burdick, K. E., Payton, A., Ollier, W., Chiba-Falek, O., Attix, D. K., Need, A. C., Cirulli, E. T., Voineskos, A. N., Stefanis, N. C., Avramopoulos, D., Hatzimanolis, A., Arking, D. E., Smyrnis, N., Bilder, R. M., Freimer, N. A., Cannon, T. D., London, E., Poldrack, R. A., Sabb, F. W., Congdon, E., Conley, E. D., Scult, M. A., Dickinson, D., Straub, R. E., Donohoe, G., Morris, D., Corvin, A., Gill, M., Hariri, A. R., Weinberger, D. R., Pendleton, N., Bitsios, P., Rujescu, D., Lahti, J., Le Hellard, S., Keller, M. C., Andreassen, O. A., Deary, I. J., Glahn, D. C., Malhotra, A. K. & Lencz, T., Aug 1 2019, In : American journal of human genetics. 105, 2, p. 334-350 17 p.

Research output: Contribution to journalArticle

Cognition
Meta-Analysis
Schizophrenia
Aptitude
Education

Polygenic risk score increases schizophrenia liability through cognition-relevant pathways

Toulopoulou, T., Zhang, X., Cherny, S., Dickinson, D., Berman, K. F., Straub, R. E., Sham, P. & Weinberger, D., Feb 1 2019, In : Brain. 142, 2, p. 471-485 15 p.

Research output: Contribution to journalArticle

Cognition
Schizophrenia
Confidence Intervals
Causality
Genome-Wide Association Study

Polygenic risk scores in clinical schizophrenia research

Weinberger, D., Jan 1 2019, In : American Journal of Psychiatry. 176, 1, p. 3-4 2 p.

Research output: Contribution to journalEditorial

Schizophrenia
Research

Population-based identity-by-descent mapping combined with exome sequencing to detect rare risk variants for schizophrenia

Wellcome Trust Case Control Consortium 2 & Schizophrenia Working Group of the Psychiatric Genomics Consortium, Apr 1 2019, In : American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 180, 3, p. 223-231 9 p.

Research output: Contribution to journalArticle

Exome
Haplotypes
Genome-Wide Association Study
Schizophrenia
Population

Prefrontal Coexpression of Schizophrenia Risk Genes Is Associated With Treatment Response in Patients

Pergola, G., Di Carlo, P., Jaffe, A., Papalino, M., Chen, Q., Hyde, T., Kleinman, J., Shin, J. H., Rampino, A., Blasi, G., Weinberger, D. & Bertolino, A., Jan 1 2019, In : Biological psychiatry.

Research output: Contribution to journalArticle

Schizophrenia
Genes
Gene Regulatory Networks
olanzapine
Prefrontal Cortex

Publisher Correction: Gene expression imputation across multiple brain regions provides insights into schizophrenia risk (Nature Genetics, (2019), 51, 4, (659-674), 10.1038/s41588-019-0364-4)

iPSYCH-GEMS Schizophrenia Working Group, CommonMind Consortium & The Schizophrenia Working Group of the Psychiatric Genomics Consortium, Jan 1 2019, In : Nature genetics.

Research output: Contribution to journalComment/debate

Open Access
Genomics
Psychiatry
Schizophrenia
Gene Expression
Brain

Regional Heterogeneity in Gene Expression, Regulation, and Coherence in the Frontal Cortex and Hippocampus across Development and Schizophrenia

BrainSeq Consortium, Jul 17 2019, In : Neuron. 103, 2, p. 203-216.e8

Research output: Contribution to journalArticle

Gene Expression Regulation
Frontal Lobe
Hippocampus
Schizophrenia
Brain

Schizophrenia risk variants influence multiple classes of transcripts of sorting nexin 19 (SNX19)

The BrainSeq Consortium, Jan 1 2019, (Accepted/In press) In : Molecular Psychiatry.

Research output: Contribution to journalArticle

Sorting Nexins
Schizophrenia
Exons
Epigenomics
Alleles

The Association Between Familial Risk and Brain Abnormalities Is Disease Specific: An ENIGMA-Relatives Study of Schizophrenia and Bipolar Disorder

de Zwarte, S. M. C., Brouwer, R. M., Agartz, I., Alda, M., Aleman, A., Alpert, K. I., Bearden, C. E., Bertolino, A., Bois, C., Bonvino, A., Bramon, E., Buimer, E. E. L., Cahn, W., Cannon, D. M., Cannon, T. D., Caseras, X., Castro-Fornieles, J., Chen, Q., Chung, Y., De la Serna, E. & 71 others, Di Giorgio, A., Doucet, G. E., Eker, M. C., Erk, S., Fears, S. C., Foley, S. F., Frangou, S., Frankland, A., Fullerton, J. M., Glahn, D. C., Goghari, V. M., Goldman, A. L., Gonul, A. S., Gruber, O., de Haan, L., Hajek, T., Hawkins, E. L., Heinz, A., Hillegers, M. H. J., Hulshoff Pol, H. E., Hultman, C. M., Ingvar, M., Johansson, V., Jönsson, E. G., Kane, F., Kempton, M. J., Koenis, M. M. G., Kopecek, M., Krabbendam, L., Krämer, B., Lawrie, S. M., Lenroot, R. K., Marcelis, M., Marsman, J. B. C., Mattay, V. S., McDonald, C., Meyer-Lindenberg, A., Michielse, S., Mitchell, P. B., Moreno, D., Murray, R. M., Mwangi, B., Najt, P., Neilson, E., Newport, J., van Os, J., Overs, B., Ozerdem, A., Picchioni, M. M., Richter, A., Roberts, G., Aydogan, A. S., Schofield, P. R., Simsek, F., Soares, J. C., Sugranyes, G., Toulopoulou, T., Tronchin, G., Walter, H., Wang, L., Weinberger, D. R., Whalley, H. C., Yalin, N., Andreassen, O. A., Ching, C. R. K., van Erp, T. G. M., Turner, J. A., Jahanshad, N., Thompson, P. M., Kahn, R. S. & van Haren, N. E. M., Oct 1 2019, In : Biological psychiatry. 86, 7, p. 545-556 12 p.

Research output: Contribution to journalArticle

Open Access
Bipolar Disorder
Schizophrenia
Brain
Psychopathology
Third Ventricle

The fetal origins of mental illness

al-Haddad, B. J. S., Oler, E., Armistead, B., Elsayed, N. A., Weinberger, D. R., Bernier, R., Burd, I., Kapur, R., Jacobsson, B., Wang, C., Mysorekar, I., Rajagopal, L. & Adams Waldorf, K. M., Jan 1 2019, In : American journal of obstetrics and gynecology.

Research output: Contribution to journalReview article

Infection
Inflammation
Brain
Pregnancy
Wounds and Injuries

The role of polygenic risk score gene-set analysis in the context of the omnigenic model of schizophrenia

The Schizophrenia Working Group of the Psychiatric Genomics Consortium 2, Jan 1 2019, In : Neuropsychopharmacology.

Research output: Contribution to journalArticle

Open Access
Schizophrenia
Genes
Up-Regulation
Down-Regulation

Thinking about schizophrenia in an era of genomic medicine

Weinberger, D., Jan 1 2019, In : American Journal of Psychiatry. 176, 1, p. 12-20 9 p.

Research output: Contribution to journalReview article

Schizophrenia
Medicine
Psychiatry
Research
Brain
2018

A correction for sample overlap in genome-wide association studies in a polygenic pleiotropy-informed framework

Schizophrenia and Bipolar Disorder Working Groups of the Psychiatric Genomics Consortium, Jun 25 2018, In : BMC Genomics. 19, 1, 494.

Research output: Contribution to journalArticle

Genome-Wide Association Study

Age at first birth in women is genetically associated with increased risk of schizophrenia

Ni, G., Gratten, J., Wray, N. R., Lee, S. H., Ripke, S., Neale, B. M., Corvin, A., Walters, J. T. R., Farh, K. H., Holmans, P. A., Lee, P., Bulik-Sullivan, B., Collier, D. A., Huang, H., Pers, T. H., Agartz, I., Agerbo, E., Albus, M., Alexander, M., Amin, F. & 281 others, Bacanu, S. A., Begemann, M., Belliveau, R. A., Bene, J., Bergen, S. E., Bevilacqua, E., Bigdeli, T. B., Black, D. W., Bruggeman, R., Buccola, N. G., Buckner, R. L., Byerley, W., Cahn, W., Cai, G., Campion, D., Cantor, R. M., Carr, V. J., Carrera, N., Catts, S. V., Chambert, K. D., Chan, R. C. K., Chen, R. Y. L., Chen, E. Y. H., Cheng, W., Cheung, E. F. C., Chong, S. A., Cloninger, C. R., Cohen, D., Cohen, N., Cormican, P., Craddock, N., Crowley, J. J., Curtis, D., Davidson, M., Davis, K. L., Degenhardt, F., Del Favero, J., Demontis, D., Dikeos, D., Dinan, T., Djurovic, S., Donohoe, G., Drapeau, E., Duan, J., Dudbridge, F., Durmishi, N., Eichhammer, P., Eriksson, J., Escott-Price, V., Essioux, L., Fanous, A. H., Farrell, M. S., Frank, J., Franke, L., Freedman, R., Freimer, N. B., Friedl, M., Friedman, J. I., Fromer, M., Genovese, G., Georgieva, L., Giegling, I., Giusti-Rodríguez, P., Godard, S., Goldstein, J. I., Golimbet, V., Gopal, S., Haan, L. D., Hammer, C., Hamshere, M. L., Hansen, M., Hansen, T., Haroutunian, V., Hartmann, A. M., Henskens, F. A., Herms, S., Hirschhorn, J. N., Hoffmann, P., Hofman, A., Hollegaard, M. V., Hougaard, D. M., Ikeda, M., Joa, I., Juliá, A., Kahn, R. S., Kalaydjieva, L., Karachanak-Yankova, S., Karjalainen, J., Kavanagh, D., Keller, M. C., Kennedy, J. L., Khrunin, A., Kim, Y., Klovins, J., Knowles, J. A., Konte, B., Kucinskas, V., Kucinskiene, Z. A., Kuzelova-Ptackova, H., Kähler, A. K., Laurent, C., Keong, J. L. C., Legge, S. E., Lerer, B., Li, M., Li, T., Liang, K. Y., Lieberman, J., Limborska, S., Loughland, C. M., Lubinski, J., Lönnqvist, J., Macek, M., Magnusson, P. K. E., Maher, B., Maier, W., Mallet, J., Marsal, S., Mattheisen, M., Mattingsdal, M., McCarley, R. W., McDonald, C., McIntosh, A. M., Meier, S., Meijer, C. J., Melegh, B., Melle, I., Mesholam-Gately, R. I., Metspalu, A., Michie, P. T., Milani, L., Milanova, V., Mokrab, Y., Morris, D. W., Mors, O., Murphy, K. C., Murray, R. M., Myin-Germeys, I., Müller-Myhsok, B., Nelis, M., Nenadic, I., Nertney, D. A., Nestadt, G., Nicodemus, K. K., Nikitina-Zake, L., Nisenbaum, L., Nordin, A., O'callaghan, E., O'dushlaine, C., O'neill, F. A., Oh, S. Y., Olincy, A., Olsen, L., Os, J. V., Pantelis, C., Papadimitriou, G. N., Papiol, S., Parkhomenko, E., Pato, M. T., Paunio, T., Pejovic-Milovancevic, M., Perkins, D. O., Pietiläinen, O., Pimm, J., Pocklington, A. J., Powell, J., Price, A., Pulver, A. E., Purcell, S. M., Quested, D., Rasmussen, H. B., Reichenberg, A., Reimers, M. A., Richards, A. L., Roffman, J. L., Roussos, P., Ruderfer, D. M., Salomaa, V., Sanders, A. R., Schall, U., Schubert, C. R., Schulze, T. G., Schwab, S. G., Scolnick, E. M., Scott, R. J., Seidman, L. J., Shi, J., Sigurdsson, E., Silagadze, T., Silverman, J. M., Sim, K., Slominsky, P., Smoller, J. W., So, H. C., Spencer, C. C. A., Stahl, E. A., Stefansson, H., Steinberg, S., Stogmann, E., Straub, R. E., Strengman, E., Strohmaier, J., Stroup, T. S., Subramaniam, M., Suvisaari, J., Svrakic, D. M., Szatkiewicz, J. P., Söderman, E., Thirumalai, S., Toncheva, D., Tosato, S., Veijola, J., Waddington, J., Walsh, D., Wang, D., Wang, Q., Webb, B. T., Weiser, M., Wildenauer, D. B., Williams, N. M., Williams, S., Witt, S. H., Wolen, A. R., Wong, E. H. M., Wormley, B. K., Xi, H. S., Zai, C. C., Zheng, X., Zimprich, F., Stefansson, K., Visscher, P. M., Adolfsson, R., Andreassen, O. A., Blackwood, D. H. R., Bramon, E., Buxbaum, J. D., Børglum, A. D., Cichon, S., Darvasi, A., Domenici, E., Ehrenreich, H., Esko, T., Gejman, P. V., Gill, M., Gurling, H., Hultman, C. M., Iwata, N., Jablensky, A. V., Jönsson, E. G., Kendler, K. S., Kirov, G., Knight, J., Lencz, T., Levinson, D. F., Li, Q. S., Liu, J., Malhotra, A. K., McCarroll, S. A., McQuillin, A., Moran, J. L., Mortensen, P. B., Mowry, B. J., Nöthen, M. M., Ophoff, R. A., Owen, M. J., Palotie, A., Pato, C. N., Petryshen, T. L., Posthuma, D., Rietschel, M., Riley, B. P., Rujescu, D., Sham, P. C., Sklar, P., Clair, D. S., Weinberger, D., Wendland, J. R., Werge, T., Daly, M. J., Sullivan, P. F. & O'donovan, M. C., Dec 1 2018, In : Scientific Reports. 8, 1, 10168.

Research output: Contribution to journalArticle

Birth Order
Schizophrenia
Parents
Mental Health
Genetic Heterogeneity

Association of a Noncoding RNA Postmortem With Suicide by Violent Means and In Vivo With Aggressive Phenotypes

Punzi, G., Ursini, G., Viscanti, G., Radulescu, E., Shin, J. H., Quarto, T., Catanesi, R., Blasi, G., Jaffe, A., Deep-Soboslay, A., Hyde, T., Kleinman, J., Bertolino, A. & Weinberger, D., Jan 1 2018, (Accepted/In press) In : Biological Psychiatry.

Research output: Contribution to journalArticle

Untranslated RNA
Suicide
Phenotype
Long Noncoding RNA
Gene Regulatory Networks

Attacking Heterogeneity in Schizophrenia by Deriving Clinical Subgroups from Widely Available Symptom Data

Dickinson, D., Pratt, D. N., Giangrande, E. J., Grunnagle, M., Orel, J., Weinberger, D., Callicott, J. H. & Berman, K. F., Jan 1 2018, In : Schizophrenia Bulletin. 44, 1, p. 101-113 13 p.

Research output: Contribution to journalArticle

Schizophrenia
Neurosciences
Neurobehavioral Manifestations
Short-Term Memory
Cluster Analysis

Convergence of placenta biology and genetic risk for schizophrenia article

Ursini, G., Punzi, G., Chen, Q., Marenco, S., Robinson, J. F., Porcelli, A., Hamilton, E. G., Mitjans, M., Maddalena, G., Begemann, M., Seidel, J., Yanamori, H., Jaffe, A., Berman, K. F., Egan, M. F., Straub, R. E., Colantuoni, C., Blasi, G., Hashimoto, R., Rujescu, D. & 3 others, Ehrenreich, H., Bertolino, A. & Weinberger, D., Jun 1 2018, In : Nature Medicine. 24, 6, p. 792-801 10 p.

Research output: Contribution to journalArticle

Placenta
Schizophrenia
Genes
Germany
Biological Phenomena

Developmental and genetic regulation of the human cortex transcriptome illuminate schizophrenia pathogenesis

The BrainSeq Consortium, Aug 1 2018, In : Nature Neuroscience. 21, 8, p. 1117-1125 9 p.

Research output: Contribution to journalArticle

Medical Genetics
Transcriptome
Schizophrenia
Quantitative Trait Loci
RNA Sequence Analysis

Developmental effects of maternal smoking during pregnancy on the human frontal cortex transcriptome

Semick, S. A., Collado-Torres, L., Markunas, C. A., Shin, J. H., Deep-Soboslay, A., Tao, R., Huestis, M. A., Bierut, L. J., Maher, B., Johnson, E. O., Hyde, T., Weinberger, D., Hancock, D. B., Kleinman, J. & Jaffe, A., Jan 1 2018, (Accepted/In press) In : Molecular Psychiatry.

Research output: Contribution to journalArticle

Frontal Lobe
Transcriptome
Smoking
Mothers
Pregnancy

Effects of Schizophrenia Polygenic Risk Scores on Brain Activity and Performance during Working Memory Subprocesses in Healthy Young Adults

Miller, J. A., Scult, M. A., Conley, E. D., Chen, Q., Weinberger, D. & Hariri, A. R., Jun 6 2018, In : Schizophrenia Bulletin. 44, 4, p. 844-853 10 p.

Research output: Contribution to journalArticle

Short-Term Memory
Young Adult
Schizophrenia
Prefrontal Cortex
Brain

Erratum to: Variations in Dysbindin-1 are associated with cognitive response to antipsychotic drug treatment (Nature Communications, (2018), 9, 1, (2265), 10.1038/s41467-018-04711-w)

Scheggia, D., Mastrogiacomo, R., Mereu, M., Sannino, S., Straub, R. E., Armando, M., Managò, F., Guadagna, S., Piras, F., Zhang, F., Kleinman, J., Hyde, T., Kaalund, S. S., Pontillo, M., Orso, G., Caltagirone, C., Borrelli, E., De Luca, M. A., Vicari, S., Weinberger, D. & 2 others, Spalletta, G. & Papaleo, F., Dec 1 2018, In : Nature Communications. 9, 1, 3560.

Research output: Contribution to journalComment/debate

Drug therapy
HTML
Manuscripts
Antipsychotic Agents
drugs

Estimation of Genetic Correlation via Linkage Disequilibrium Score Regression and Genomic Restricted Maximum Likelihood

Wellcome Trust Case Control Consortium, Schizophrenia Working Group of the Psychiatric Genomics Consortium & Psychosis Endophenotypes International Consortium, Jun 7 2018, In : American Journal of Human Genetics. 102, 6, p. 1185-1194 10 p.

Research output: Contribution to journalArticle

Linkage Disequilibrium
Schizophrenia
Likelihood Functions
Genetic Heterogeneity
Nucleic Acid Regulatory Sequences

GAD1 alternative transcripts and DNA methylation in human prefrontal cortex and hippocampus in brain development, schizophrenia

Tao, R., Davis, K. N., Li, C., Shin, J. H., Gao, Y., Jaffe, A., Gondré-Lewis, M. C., Weinberger, D., Kleinman, J. & Hyde, T., Jun 1 2018, In : Molecular Psychiatry. 23, 6, p. 1496-1505 10 p.

Research output: Contribution to journalArticle

DNA Methylation
Prefrontal Cortex
Hippocampus
Schizophrenia
gamma-Aminobutyric Acid

Genetic vulnerability to DUSP22 promoter hypermethylation is involved in the relation between in utero famine exposure and schizophrenia

Boks, M. P., Houtepen, L. C., Xu, Z., He, Y., Ursini, G., Maihofer, A. X., Rajarajan, P., Yu, Q., Xu, H., Wu, Y., Wang, S., Shi, J. P., Hulshoff Pol, H. E., Strengman, E., Rutten, B. P. F., Jaffe, A., Kleinman, J., Baker, D. G., Hol, E. M., Akbarian, S. & 6 others, Nievergelt, C. M., De Witte, L. D., Vinkers, C. H., Weinberger, D., Yu, J. & Kahn, R. S., Dec 1 2018, In : npj Schizophrenia. 4, 1, 16.

Research output: Contribution to journalArticle

Dual-Specificity Phosphatases
Starvation
Schizophrenia
Methylation
DNA Methylation

Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence

Savage, J. E., Jansen, P. R., Stringer, S., Watanabe, K., Bryois, J., De Leeuw, C. A., Nagel, M., Awasthi, S., Barr, P. B., Coleman, J. R. I., Grasby, K. L., Hammerschlag, A. R., Kaminski, J. A., Karlsson, R., Krapohl, E., Lam, M., Nygaard, M., Reynolds, C. A., Trampush, J. W., Young, H. & 97 others, Zabaneh, D., Hägg, S., Hansell, N. K., Karlsson, I. K., Linnarsson, S., Montgomery, G. W., Muñoz-Manchado, A. B., Quinlan, E. B., Schumann, G., Skene, N. G., Webb, B. T., White, T., Arking, D., Avramopoulos, D., Bilder, R. M., Bitsios, P., Burdick, K. E., Cannon, T. D., Chiba-Falek, O., Christoforou, A., Cirulli, E. T., Congdon, E., Corvin, A., Davies, G., Deary, I. J., Derosse, P., Dickinson, D., Djurovic, S., Donohoe, G., Conley, E. D., Eriksson, J. G., Espeseth, T., Freimer, N. A., Giakoumaki, S., Giegling, I., Gill, M., Glahn, D. C., Hariri, A. R., Hatzimanolis, A., Keller, M. C., Knowles, E., Koltai, D., Konte, B., Lahti, J., Le Hellard, S., Lencz, T., Liewald, D. C., London, E., Lundervold, A. J., Malhotra, A. K., Melle, I., Morris, D., Need, A. C., Ollier, W., Palotie, A., Payton, A., Pendleton, N., Poldrack, R. A., Räikkönen, K., Reinvang, I., Roussos, P., Rujescu, D., Sabb, F. W., Scult, M. A., Smeland, O. B., Smyrnis, N., Starr, J. M., Steen, V. M., Stefanis, N. C., Straub, R. E., Sundet, K., Tiemeier, H., Voineskos, A. N., Weinberger, D., Widen, E., Yu, J., Abecasis, G., Andreassen, O. A., Breen, G., Christiansen, L., Debrabant, B., Dick, D. M., Heinz, A., Hjerling-Leffler, J., Ikram, M. A., Kendler, K. S., Martin, N. G., Medland, S. E., Pedersen, N. L., Plomin, R., Polderman, T. J. C., Ripke, S., Van Der Sluis, S., Sullivan, P. F., Vrieze, S. I., Wright, M. J. & Posthuma, D., Jul 1 2018, In : Nature Genetics. 50, 7, p. 912-919 8 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Intelligence
Meta-Analysis
Mendelian Randomization Analysis
Genes

Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes

Bipolar Disorder and Schizophrenia Working Group of the Psychiatric Genomics Consortium douglas.ruderfer@vanderbilt.edu, Psychosis Endophenotypes International Consortium & Wellcome Trust Case Control Consortium, Jun 14 2018, In : Cell. 173, 7, p. 1705-1715.e16

Research output: Contribution to journalArticle

Dissection
Bipolar Disorder
Schizophrenia
Genes
Potassium

Identification and prioritization of gene sets associated with schizophrenia risk by co-expression network analysis in human brain

Radulescu, E., Jaffe, A., Straub, R. E., Chen, Q., Shin, J. H., Hyde, T., Kleinman, J. & Weinberger, D., Jan 1 2018, (Accepted/In press) In : Molecular Psychiatry.

Research output: Contribution to journalArticle

Schizophrenia
Brain
Genes
Biological Ontologies
RNA

Integrative functional genomic analysis of human brain development and neuropsychiatric risks

BrainSpan Consortium, PsychENCODE Consortium & PsychENCODE Developmental Subgroup, Dec 14 2018, In : Science. 362, 6420, 1264.

Research output: Contribution to journalArticle

Human Development
Epigenomics
Brain
Gene Regulatory Networks
Genes

Interaction of childhood urbanicity and variation in dopamine genes alters adult prefrontal function as measured by functional magnetic resonance imaging (fMRI)

Reed, J. L., D’Ambrosio, E., Marenco, S., Ursini, G., Zheutlin, A. B., Blasi, G., Spencer, B. E., Romano, R., Hochheiser, J., Reifman, A., Sturm, J., Berman, K. F., Bertolino, A., Weinberger, D. & Callicott, J. H., Apr 1 2018, In : PLoS One. 13, 4, e0195189.

Research output: Contribution to journalArticle

dopamine
magnetic resonance imaging
childhood
Dopamine
Genes

Investigating the neuroimmunogenic architecture of schizophrenia

Birnbaum, R., Jaffe, A., Chen, Q., Shin, J. H., Kleinman, J., Hyde, T. & Weinberger, D., May 1 2018, In : Molecular Psychiatry. 23, 5, p. 1251-1260 10 p.

Research output: Contribution to journalArticle

Schizophrenia
Prefrontal Cortex
Genes
Immune System
Hippocampus

Longitudinal analyses of the DNA methylome in deployed military servicemen identify susceptibility loci for post-traumatic stress disorder

Rutten, B. P. F., Vermetten, E., Vinkers, C. H., Ursini, G., Daskalakis, N. P., Pishva, E., De Nijs, L., Houtepen, L. C., Eijssen, L., Jaffe, A., Kenis, G., Viechtbauer, W., Van Den Hove, D., Schraut, K. G., Lesch, K. P., Kleinman, J., Hyde, T., Weinberger, D., Schalkwyk, L., Lunnon, K. & 8 others, Mill, J., Cohen, H., Yehuda, R., Baker, D. G., Maihofer, A. X., Nievergelt, C. M., Geuze, E. & Boks, M. P. M., May 1 2018, In : Molecular Psychiatry. 23, 5, p. 1145-1156 12 p.

Research output: Contribution to journalArticle

Post-Traumatic Stress Disorders
DNA Methylation
DNA
Military Personnel
Wounds and Injuries

Multi-Trait analysis of gwas and biological insights into cognition: A response to hill (2018)

Lam, M., Trampush, J. W., Yu, J., Knowles, E., Djurovic, S., Melle, I., Sundet, K., Christoforou, A., Reinvang, I., Derosse, P., Lundervold, A. J., Steen, V. M., Espeseth, T., Räikkönen, K., Widen, E., Palotie, A., Eriksson, J. G., Giegling, I., Konte, B., Roussos, P. & 41 others, Giakoumaki, S., Burdick, K. E., Payton, A., Ollier, W., Chiba-Falek, O., Attix, D. K., Need, A. C., Cirulli, E. T., Voineskos, A. N., Stefanis, N. C., Avramopoulos, D., Hatzimanolis, A., Arking, D., Smyrnis, N., Bilder, R. M., Freimer, N. A., Cannon, T. D., London, E., Poldrack, R. A., Sabb, F. W., Congdon, E., Conley, E. D., Scult, M. A., Dickinson, D., Straub, R. E., Donohoe, G., Morris, D., Corvin, A., Gill, M., Hariri, A. R., Weinberger, D., Pendleton, N., Bitsios, P., Rujescu, D., Lahti, J., Hellard, S. L., Keller, M. C., Andreassen, O. A., Glahn, D. C., Malhotra, A. K. & Lencz, T., Oct 1 2018, In : Twin Research and Human Genetics. 21, 5, p. 394-397 4 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Cognition
Medical Genetics
Nootropic Agents
Economic Inflation

Novel inhibitors of As(III) S-adenosylmethionine methyltransferase (AS3MT) identified by virtual screening

Bürli, R. W., Wei, H., Ernst, G., Mariga, A., Hardern, I. M., Herlihy, K., Cross, A. J., Wesolowski, S. S., Chen, H., McKay, R. D. G., Weinberger, D., Brandon, N. J. & Barrow, J., Oct 15 2018, In : Bioorganic and Medicinal Chemistry Letters. 28, 19, p. 3231-3235 5 p.

Research output: Contribution to journalArticle

S-Adenosylmethionine
Methyltransferases
Screening
Enzyme Assays
Scaffolds

Role of gamma-amino-butyric acid in the dorsal anterior cingulate in age-associated changes in cognition

Marenco, S., Meyer, C., van der Veen, J. W., Zhang, Y., Kelly, R., Shen, J., Weinberger, D., Dickinson, D. & Berman, K. F., Oct 1 2018, In : Neuropsychopharmacology. 43, 11, p. 2285-2291 7 p.

Research output: Contribution to journalArticle

Butyric Acid
Gyrus Cinguli
gamma-Aminobutyric Acid
Cognition
Magnetic Resonance Spectroscopy

Schizophrenia polygenic risk score predicts mnemonic hippocampal activity

Chen, Q., Ursini, G., Romer, A. L., Knodt, A. R., Mezeivtch, K., Xiao, E., Pergola, G., Blasi, G., Straub, R. E., Callicott, J. H., Berman, K. F., Hariri, A. R., Bertolino, A., Mattay, V. & Weinberger, D., Apr 1 2018, In : Brain. 141, 4, p. 1218-1228 11 p.

Research output: Contribution to journalArticle

Schizophrenia
Healthy Volunteers
Genome-Wide Association Study
Masks
Alleles