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2019
Obstructive Lung Diseases
Chronic Obstructive Pulmonary Disease
Nebulizers and Vaporizers
Adrenal Cortex Hormones
Outcome Assessment (Health Care)

Aspirin Use and Respiratory Morbidity in COPD: A Propensity Score-Matched Analysis in Subpopulations and Intermediate Outcome Measures in COPD Study

SPIROMICS investigators, Mar 1 2019, In : CHEST. 155, 3, p. 519-527 9 p.

Research output: Contribution to journalArticle

Propensity Score
Chronic Obstructive Pulmonary Disease
Aspirin
Outcome Assessment (Health Care)
Morbidity

Association of platelet count with all-cause mortality and risk of cardiovascular and respiratory morbidity in stable COPD

Fawzy, A., Anderson, J. A., Cowans, N. J., Crim, C., Wise, R. A., Yates, J. C. & Hansel, N., May 8 2019, In : Respiratory research. 20, 1, 86.

Research output: Contribution to journalArticle

Open Access
Platelet Count
Chronic Obstructive Pulmonary Disease
Morbidity
Mortality
Confidence Intervals

Blood eosinophils and treatment response with triple and dual combination therapy in chronic obstructive pulmonary disease: analysis of the IMPACT trial

Pascoe, S., Barnes, N., Brusselle, G., Compton, C., Criner, G. J., Dransfield, M. T., Halpin, D. M. G., Han, M. L. K., Hartley, B., Lange, P., Lettis, S., Lipson, D. A., Lomas, D. A., Martinez, F. J., Papi, A., Roche, N., van der Valk, R. J. P., Wise, R. A. & Singh, D., Sep 1 2019, In : The Lancet Respiratory Medicine. 7, 9, p. 745-756 12 p.

Research output: Contribution to journalArticle

Eosinophils
Chronic Obstructive Pulmonary Disease
Adrenal Cortex Hormones
Dyspnea
Therapeutics

BMI but not central obesity predisposes to airway closure during bronchoconstriction

Peters, U., Subramanian, M., Chapman, D. G., Kaminsky, D. A., Irvin, C. G., Wise, R. A., Skloot, G. S., Bates, J. H. T. & Dixon, A. E., Jan 1 2019, In : Respirology.

Research output: Contribution to journalArticle

Bronchoconstriction
Abdominal Obesity
Waist Circumference
Body Mass Index
Methacholine Chloride
National Heart, Lung, and Blood Institute (U.S.)
Anniversaries and Special Events
Chronic Obstructive Pulmonary Disease
Lung Diseases
Clinical Trials

Clinical characterization of children with resistant airflow obstruction, a multicenter study

on behalf of the American Lung Association Airway Clinical Research Centers (ALA-ACRC) Network, Jun 3 2019, In : Journal of Asthma. 56, 6, p. 611-617 7 p.

Research output: Contribution to journalArticle

Multicenter Studies
Bronchodilator Agents
Asthma
Lung
Tobacco Smoke Pollution

Compartmentalization of anti-oxidant and anti-inflammatory gene expression in current and former smokers with COPD

Sidhaye, V., Holbrook, J. T., Burke, A., Sudini, K. R., Sethi, S., Criner, G. J., Fahey, J. W., Berenson, C. S., Jacobs, M. R., Thimmulappa, R., Wise, R. A. & Biswal, S., Aug 20 2019, In : Respiratory research. 20, 1, 190.

Research output: Contribution to journalArticle

Open Access
Oxidants
Chronic Obstructive Pulmonary Disease
Anti-Inflammatory Agents
Gene Expression
Oxidative Stress

Diffusing Capacity of Carbon Monoxide in Assessment of COPD

Balasubramanian, A., MacIntyre, N. R., Henderson, R. J., Jensen, R. L., Kinney, G., Stringer, W. W., Hersh, C. P., Bowler, R. P., Casaburi, R., Han, M. L. K., Porszasz, J., Barr, R. G., Make, B. J., Wise, R. A. & McCormack, M. C., Jan 1 2019, (Accepted/In press) In : CHEST.

Research output: Contribution to journalArticle

Carbon Monoxide
Chronic Obstructive Pulmonary Disease
Emphysema
Spirometry
Quality of Life

Do Baseline Asthma and Allergic Sensitization Characteristics Predict Responsiveness to Mouse Allergen Reduction?

Ahmed, A., Sadreameli, C., Curtin-Brosnan, J., Grant, T., Phipatanakul, W., Perzanowski, M., Balcer-Whaley, S., Peng, R., Newman, M., Cunningham, A., Divjan, A., Bollinger, M. E., Wise, R. A., Miller, R., Chew, G. & Matsui, E. C., Jan 1 2019, (Accepted/In press) In : Journal of Allergy and Clinical Immunology: In Practice.

Research output: Contribution to journalArticle

Allergens
Asthma
Lung
Hispanic Americans
Immunoglobulin E

Effect of Aclidinium Bromide on Major Cardiovascular Events and Exacerbations in High-Risk Patients With Chronic Obstructive Pulmonary Disease: The ASCENT-COPD Randomized Clinical Trial

Wise, R. A., Chapman, K. R., Scirica, B. M., Bhatt, D. L., Daoud, S. Z., Zetterstrand, S., Reisner, C. & Gil, E. G., May 7 2019, In : JAMA. 321, 17, p. 1693-1701 9 p.

Research output: Contribution to journalArticle

Chronic Obstructive Pulmonary Disease
Randomized Controlled Trials
Placebos
Disease Progression
Hospitalization
Open Access
Self Care
Chronic Obstructive Pulmonary Disease
Randomized Controlled Trials
Hospitalization
Quality of Life

Frailty and clinical outcomes in chronic obstructive pulmonary disease

NETT Research Group, Feb 1 2019, In : Annals of the American Thoracic Society. 16, 2, p. 217-224 8 p.

Research output: Contribution to journalArticle

Chronic Obstructive Pulmonary Disease
Confidence Intervals
Emphysema
Forced Expiratory Volume
Phenotype

Identifying an at-risk population for poor asthma outcomes: Data from the American Lung Association Asthma Clinical Trials Registry

Bose, S., Henderson, R. J., Rogers, L., Casale, T., Skloot, G., Soler, X., Wise, R. A. & Que, L. G., Jan 1 2019, In : Journal of Allergy and Clinical Immunology: In Practice.

Research output: Contribution to journalArticle

Registries
Asthma
Clinical Trials
Lung

Introducing the new COPD pocket consultant guide app: Can a digital approach improve care? A statement of the COPD foundation

Thomashow, B., Crapo, J. D., Bradley Drummond, M., Han, M. L. K., Kalhan, R., Malanga, E., Malanga, V., Mannino, D. M., Rennard, S., Sciurba, F. C., Willard, K. S., Wise, R. & Yawn, B., Jan 1 2019, In : Chronic Obstructive Pulmonary Diseases. 6, 3, p. 210-220 11 p.

Research output: Contribution to journalReview article

Consultants
Chronic Obstructive Pulmonary Disease
Spirometry
Chronic Bronchitis
Emphysema

Investigation of the Obesity Paradox in Chronic Obstructive Pulmonary Disease, According to Smoking Status, in the United States

Wu, T. D., Ejike, C. O., Wise, R. A., Mccormack, M. C. & Brigham, E. P., Nov 1 2019, In : American journal of epidemiology. 188, 11, p. 1977-1983 7 p.

Research output: Contribution to journalArticle

Chronic Obstructive Pulmonary Disease
Obesity
Smoking
Confidence Intervals
Nutrition Surveys

Lung cancer-related mortality with inhaled insulin or a comparator: Follow-up study of patients previously enrolled in exubera controlled clinical trials (FUSE) final results

Gatto, N. M., Koralek, D. O., Bracken, M. B., Duggan, W. T., Lem, J., Klioze, S., Koch, G. G., Wise, R. A., Cohen, R. B. & Jackson, N. C., Sep 1 2019, In : Diabetes care. 42, 9, p. 1708-1715 8 p.

Research output: Contribution to journalArticle

Controlled Clinical Trials
Lung Neoplasms
Insulin
Mortality
Cohort Studies

Misinterpretation of time-to-first event curves can lead to inappropriate treatment

Hartley, B., Criner, G. J., Dransfield, M. T., Halpin, D. M. G., Han, M. L. K., Elaine Jones, C., Kilbride, S., Lange, P., Lipson, D. A., Lomas, D. A., Martin, N., Martinez, F. J., Singh, D., Wise, R. A. & Lettis, S., Sep 1 2019, In : European Respiratory Journal. 54, 3, 1900634.

Research output: Contribution to journalLetter

Open Access

Nanoparticle diffusion in spontaneously expectorated sputum as a biophysical tool to probe disease severity in COPD

Chisholm, J. F., Shenoy, S. K., Shade, J. K., Kim, V., Putcha, N., Carson, K. A., Wise, R. A., Hansel, N., Hanes, J. S., Suk, J. S. & Neptune, E., Aug 1 2019, In : European Respiratory Journal. 54, 2, 1900088.

Research output: Contribution to journalArticle

Open Access
Sputum
Nanoparticles
Chronic Obstructive Pulmonary Disease
Mucus
Lung

Older age and obesity are associated with increased airway closure in response to methacholine in patients with asthma

Kaminsky, D. A., Chapman, D. G., Holbrook, J. T., Henderson, R. J., Sugar, E., Mastronarde, J., Teague, W. G., Busk, M., Sumino, K., Dixon, A. E., Wise, R. A. & Irvin, C. G., Jan 1 2019, In : Respirology.

Research output: Contribution to journalArticle

Methacholine Chloride
Forced Expiratory Volume
Vital Capacity
Asthma
Obesity

Plasma cathelicidin and longitudinal lung function in current and former smokers

Burkes, R. M., Astemborski, J., Lambert, A. A., Brown, T. T., Wise, R. A., Kirk, G. D. & Drummond, M. B., Feb 1 2019, In : PloS one. 14, 2, e0212628.

Research output: Contribution to journalArticle

Open Access
lung function
vitamin D
Plasmas
Lung
risk groups

Prevalencia de enfermedades respiratorias crónicas en zonas urbanas y rurales de uganda

Translated title of the contribution: Prevalence of chronic respiratory disease in urban and rural ugandaSiddharthan, T., Grigsby, M., Morgan, B., Kalyesubula, R., Wise, R. A., Kirengab, B. & Checkleya, W., May 1 2019, In : Bulletin of the World Health Organization. 97, 5, p. 318-327 10 p.

Research output: Contribution to journalArticle

Open Access
Uganda
Spirometry
Chronic Disease
Chronic Obstructive Pulmonary Disease
Asthma
Self Medication
Self Care
Chronic Obstructive Pulmonary Disease
Anti-Anxiety Agents
Hypnotics and Sedatives
Chronic Obstructive Pulmonary Disease
Antidepressive Agents
Anxiety

The health and social implications of household air pollution and respiratory diseases

Simkovich, S. M., Goodman, D., Roa, C., Crocker, M. E., Gianella, G. E., Kirenga, B. J., Wise, R. A. & Checkley, W., Dec 1 2019, In : npj Primary Care Respiratory Medicine. 29, 1, 12.

Research output: Contribution to journalReview article

Open Access
Air Pollution
Health
Lung Neoplasms
Pneumoconiosis
Environmental Monitoring

The St. George's Respiratory Questionnaire Definition of Chronic Bronchitis May Be a Better Predictor of COPD Exacerbations Compared With the Classic Definition

COPDGene Investigators, Oct 2019, In : CHEST. 156, 4, p. 685-695 11 p.

Research output: Contribution to journalArticle

Chronic Bronchitis
Chronic Obstructive Pulmonary Disease
Surveys and Questionnaires
2018

Anemia and adverse outcomes in a chronic obstructive pulmonary disease population with a high burden of comorbidities an analysis from SPIROMICS

on behalf of the SPIROMICS Investigators, Jun 1 2018, In : Annals of the American Thoracic Society. 15, 6, p. 710-717 8 p.

Research output: Contribution to journalArticle

Chronic Obstructive Pulmonary Disease
Comorbidity
Anemia
Outcome Assessment (Health Care)
Population

Association between household air pollution exposure and chronic obstructive pulmonary disease outcomes in 13 low- and middle-income country settings

Siddharthan, T., Grigsby, M. R., Goodman, D., Chowdhury, M., Rubinstein, A., Irazola, V., Gutierrez, L., Jaime Miranda, J., Bernabe-Ortiz, A., Alam, D., Kirenga, B., Jones, R., Van Gemert, F., Wise, R. A. & Checkley, W., Mar 1 2018, In : American Journal of Respiratory and Critical Care Medicine. 197, 5, p. 611-620 10 p.

Research output: Contribution to journalArticle

Air Pollution
Chronic Obstructive Pulmonary Disease
Biomass
Population
Smoking

Association of thrombocytosis with COPD morbidity: The SPIROMICS and COPDGene cohorts

and for the SPIROMICS and COPDGene Investigators, Jan 26 2018, In : Respiratory Research. 19, 1, 20.

Research output: Contribution to journalArticle

Thrombocytosis
Chronic Obstructive Pulmonary Disease
Morbidity
Confidence Intervals
Odds Ratio

Asthma and Allergic Disorders in Uganda: A Population-Based Study Across Urban and Rural Settings

Morgan, B. W., Siddharthan, T., Grigsby, M. R., Pollard, S., Kalyesubula, R., Wise, R. A., Kirenga, B. & Checkley, W., Jan 1 2018, (Accepted/In press) In : Journal of Allergy and Clinical Immunology: In Practice.

Research output: Contribution to journalArticle

Uganda
Asthma
Confidence Intervals
Population
Urbanization

Blood eosinophil count thresholds and exacerbations in patients with chronic obstructive pulmonary disease

COPDGene and ECLIPSE Investigators, Jun 1 2018, In : Journal of Allergy and Clinical Immunology. 141, 6, p. 2037-2047.e10

Research output: Contribution to journalArticle

Eosinophils
Chronic Obstructive Pulmonary Disease
Biomarkers
Cell Count
Molecular Epidemiology

Centrilobular emphysema and coronary artery calcification: Mediation analysis in the SPIROMICS cohort

Bhatt, S. P., Nath, H. P., Kim, Y. I., Ramachandran, R., Watts, J. R., Terry, N. L. J., Sonavane, S., Deshmane, S. P., Woodruff, P. G., Oelsner, E. C., Bodduluri, S., Han, M. K., Labaki, W. W., Michael Wells, J., Martinez, F. J., Barr, R. G., Dransfield, M. T., Alexis, N. E., Anderson, W. H., Bleecker, E. R. & 35 others, Boucher, R. C., Bowler, R. P., Carretta, E. E., Christenson, S. A., Comellas, A. P., Cooper, C. B., Couper, D. J., Criner, G. J., Crystal, R. G., Curtis, J. L., Doerschuk, C. M., Freeman, C. M., Hansel, N. N., Hastie, A. T., Hoffman, E. A., Kaner, R. J., Kanner, R. E., Kleerup, E. C., Krishnan, J. A., Lavange, L. M., Lazarus, S. C., Meyers, D. A., Moore, W. C., Newell, J. D., Paulin, L., Peters, S., O'Neal, W. K., Ortega, V. E., Paine, R., Putcha, N., Rennard, S. I., Tashkin, D. P., Scholand, M. B., Michael Wells, J. & Wise, R. A., Dec 18 2018, In : Respiratory Research. 19, 1, 257.

Research output: Contribution to journalArticle

Pulmonary Emphysema
Coronary Vessels
Emphysema
Chronic Obstructive Pulmonary Disease
Inflammation

Clinical differences in COPD patients with variable patterns of hypoxemia

For the Long-Term Oxygen Treatment Trial Research Group, Jan 1 2018, In : Chronic Obstructive Pulmonary Diseases. 5, 3, p. 167-178 12 p.

Research output: Contribution to journalArticle

Chronic Obstructive Pulmonary Disease
Oxygen
Hypoxia
Oximetry
Body Mass Index

Development of a novel digital breath-activated inhaler: Initial particle size characterization and clinical testing

Kesten, S., Israel, E., Li, G., Mitchell, J., Wise, R. A. & Stern, T., Dec 1 2018, In : Pulmonary Pharmacology and Therapeutics. 53, p. 27-32 6 p.

Research output: Contribution to journalArticle

Albuterol
Nebulizers and Vaporizers
Particle Size
Particle size
Fog

Does Obesity Increase Respiratory Tract Infections in Patients with Asthma?

Tang, M., Henderson, R. J., Holbrook, J. T., Que, L. G., Mathews, A. M., Wise, R. A., Dixon, A. E., Peters, S. P., Rogers, L., Smith, L. J., Teague, W. G. & Lang, J. E., Jan 1 2018, (Accepted/In press) In : Journal of Allergy and Clinical Immunology: In Practice.

Research output: Contribution to journalArticle

Respiratory Tract Infections
Asthma
Obesity
Body Mass Index
Steroids

Effectiveness-implementation of COPD case finding and self-management action plans in low- and middle-income countries: Global excellence in COPD outcomes (GECo) study protocol

Siddharthan, T., Pollard, S. L., Quaderi, S. A., Mirelman, A. J., Cárdenas, M. K., Kirenga, B., Rykiel, N. A., Miranda, J. J., Shrestha, L., Chandyo, R. K., Cattamanchi, A., Michie, S., Barber, J., Checkley, W., Hurst, J. R., Hurst, J. R., Anastasiou, Z., Pollard, S. L., Morgan, B., Rykiel, N. A. & 15 others, Grigsby, M., Robertson, N., Wise, R. A., Yogi, K. N., Sharma, A., Chandyo, R. K., Alupo, P., Muwonge, D., Mawanda, D., Nassali, F., Kalyesubula, R., Mirelman, A. J., Soares, M., Flores-Flores, O. & Romani-Huacani, E., Oct 19 2018, In : Trials. 19, 1, 571.

Research output: Contribution to journalArticle

Self Care
Chronic Obstructive Pulmonary Disease
Outcome Assessment (Health Care)
Disease Management
Spirometry
Self Care
Chronic Obstructive Pulmonary Disease
Randomized Controlled Trials
Hospitalization
Quality of Life

Efficacy of Mycophenolate Mofetil and Oral Cyclophosphamide on Skin Thickness: Post Hoc Analyses From Two Randomized Placebo-Controlled Trials

Participants in the Scleroderma Lung Study I and members of the Scleroderma Lung Study II Research Group, Mar 1 2018, In : Arthritis Care and Research. 70, 3, p. 439-444 6 p.

Research output: Contribution to journalArticle

Mycophenolic Acid
Cyclophosphamide
Randomized Controlled Trials
Placebos
Lung

Environmental exposures and systemic hypertension are risk factors for decline in lung function

CRONICAS Cohort Study Group, Dec 1 2018, In : Thorax. 73, 12, p. 1120-1127 8 p.

Research output: Contribution to journalArticle

Bronchodilator Agents
Environmental Exposure
Hypertension
Lung
Urbanization

Epidemiology and risk factors of asthma-chronic obstructive pulmonary disease overlap in low- and middle-income countries

Morgan, B. W., Grigsby, M. R., Siddharthan, T., Chowdhury, M., Rubinstein, A., Gutierrez, L., Irazola, V., Miranda, J. J., Bernabe-Ortiz, A., Alam, D., Wise, R. A. & Checkley, W., Jan 1 2018, (Accepted/In press) In : Journal of Allergy and Clinical Immunology.

Research output: Contribution to journalArticle

Chronic Obstructive Pulmonary Disease
Epidemiology
Asthma
Odds Ratio
Smoke

Fluticasone furoate, vilanterol, and lung function decline in patients with moderate chronic obstructive pulmonary disease and heightened cardiovascular risk

SUMMIT (Study to Understand Mortality and Morbidity) Investigators, Jan 1 2018, In : American Journal of Respiratory and Critical Care Medicine. 197, 1, p. 47-55 9 p.

Research output: Contribution to journalArticle

Chronic Obstructive Pulmonary Disease
Lung
Placebos
Spirometry
vilanterol

Genome-wide association study of lung function and clinical implication in heavy smokers

for the SPIROMICS Research Group, Aug 1 2018, In : BMC Medical Genetics. 19, 1, 134.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Chronic Obstructive Pulmonary Disease
Bronchodilator Agents
Lung
Genotype

Lobar Emphysema Distribution Is Associated With 5-Year Radiological Disease Progression

for the, Jan 1 2018, In : Chest. 153, 1, p. 65-76 12 p.

Research output: Contribution to journalArticle

Emphysema
Disease Progression
Chronic Obstructive Pulmonary Disease
alpha 1-Antitrypsin Deficiency
Molecular Epidemiology

Longitudinal phenotypes and mortality in preserved ratio impaired spirometry in the COPDGene study

For the COPDGene Investigators, Dec 1 2018, In : American Journal of Respiratory and Critical Care Medicine. 198, 11, p. 1397-1405 9 p.

Research output: Contribution to journalArticle

Spirometry
Phenotype
Mortality
Lung
Tomography

Long-term evaluation of the effects of Aclidinium bromide on major adverse cardiovascular events and COPD exacerbations in patients with moderate to very severe COPD: Rationale and design of the ASCENT COPD study

Wise, R. A., Chapman, K. R., Scirica, B. M., Schoenfeld, D. A., Bhatt, D. L., Daoud, S. Z., Seoane, B., Reisner, C. & Gil, E. G., Jan 1 2018, In : Chronic Obstructive Pulmonary Diseases. 5, 1, p. 5-15 11 p.

Research output: Contribution to journalArticle

Chronic Obstructive Pulmonary Disease
Disease Progression
Muscarinic Antagonists
Safety
Therapeutics

Lower serum IgA is associated with COPD exacerbation risk in SPIROMICS

Putcha, N., Paul, G. G., Azar, A., Wise, R. A., O'Neal, W. K., Dransfield, M. T., Woodruff, P. G., Curtis, J. L., Comellas, A. P., Drummond, M. B., Lambert, A. A., Paulin, L. M., Fawzy, A., Kanner, R. E., Paine, R., Han, M. L. K., Martinez, F. J., Bowler, R. P., Barr, R. G. & Hansel, N., Jan 1 2018, In : PLoS One. 13, 4, e0194924.

Research output: Contribution to journalArticle

Immunoglobulin A
Chronic Obstructive Pulmonary Disease
Serum
cohort studies
dose response

Medication regimens for managing copd exacerbations

Putcha, N. & Wise, R. A., Jun 1 2018, In : Respiratory Care. 63, 6, p. 773-782 10 p.

Research output: Contribution to journalArticle

Chronic Obstructive Pulmonary Disease
Adrenal Cortex Hormones
Anti-Bacterial Agents
Bronchodilator Agents
Pharmaceutical Preparations

Once-daily single-inhaler triple versus dual therapy in patients with COPD

IMPACT Investigators, Jan 1 2018, In : New England Journal of Medicine. 378, 18, p. 1671-1680 10 p.

Research output: Contribution to journalArticle

Nebulizers and Vaporizers
Chronic Obstructive Pulmonary Disease
Glucocorticoids
Muscarinic Antagonists
Therapeutics

Patterns of Body Composition Relating to Chronic Respiratory Diseases Among Adults in Four Resource-Poor Settings in Peru

CRONICAS Cohort Study, Mar 20 2018, (Accepted/In press) In : Lung. p. 1-8 8 p.

Research output: Contribution to journalArticle

Peru
Body Composition
Chronic Obstructive Pulmonary Disease
Chronic Disease
Waist Circumference