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2020

Somatic mitochondrial mutation discovery using ultra-deep sequencing of the mitochondrial genome reveals spatial tumor heterogeneity in head and neck squamous cell carcinoma

Schubert, A. D., Channah Broner, E., Agrawal, N., London, N., Pearson, A., Gupta, A., Wali, N., Seiwert, T. Y., Wheelan, S., Lingen, M., Macleod, K., Allen, H., Chatterjee, A., Vassiliki, S., Gaykalova, D., Hoque, M. O., Sidransky, D., Suresh, K. & Izumchenko, E., Feb 28 2020, In : Cancer Letters. 471, p. 49-60 12 p.

Research output: Contribution to journalArticle

High-Throughput Nucleotide Sequencing
Mitochondrial Genome
Mitochondrial DNA
Mutation
Neoplasms
2019

Chronic shisha exposure alters phosphoproteome of oral keratinocytes

Patil, S., Rajagopalan, P., Patel, K., Subbannayya, T., Babu, N., Mohan, S. V., Advani, J., Sathe, G., Bhandi, S., Solanki, H. S., Sidransky, D., Chatterjee, A., Gowda, H. & Ferrari, M., Jan 1 2019, In : Journal of Cell Communication and Signaling.

Research output: Contribution to journalArticle

Keratinocytes
Mouth Neoplasms
Eukaryotic Initiation Factor-4F
Proteins
Cells

Immune profiles in primary squamous cell carcinoma of the head and neck

Saloura, V., Izumchenko, E., Zuo, Z., Bao, R., Korzinkin, M., Ozerov, I., Zhavoronkov, A., Sidransky, D., Bedi, A., Hoque, M. O., Koeppen, H., Keck, M. K., Khattri, A., London, N., Kotlov, N., Fatima, A., Vougiouklakis, T., Nakamura, Y., Lingen, M., Agrawal, N. & 5 others, Savage, P. A., Kron, S., Kline, J., Kowanetz, M. & Seiwert, T. Y., Sep 1 2019, In : Oral Oncology. 96, p. 77-88 12 p.

Research output: Contribution to journalArticle

Neoplasms
Regulatory T-Lymphocytes
Mutation
Macrophages
Carcinoma, squamous cell of head and neck

JAK3 variant, immune signatures, DNA methylation, and social determinants linked to survival racial disparities in head and neck cancer patients

Guerrero-Preston, R., Lawson, F., Rodriguez-Torres, S., Noordhuis, M. G., Pirini, F., Manuel, L., Valle, B. L., Hadar, T., Rivera, B., Folawiyo, O., Baez, A., Marchionni, L., Koch, W. M., Westra, W. H., Kim, Y. J., Eshleman, J. & Sidransky, D., Apr 1 2019, In : Cancer Prevention Research. 12, 4, p. 255-270 16 p.

Research output: Contribution to journalArticle

DNA Methylation
Head and Neck Neoplasms
Germ-Line Mutation
Methylation
Survival

MAP2K1 is a potential therapeutic target in erlotinib resistant head and neck squamous cell carcinoma

Jain, A. P., Patel, K., Pinto, S., Radhakrishnan, A., Nanjappa, V., Kumar, M., Raja, R., Patil, A. H., Kumari, A., Manoharan, M., Karunakaran, C., Murugan, S., Keshava Prasad, T. S., Chang, X., Mathur, P. P., Kumar, P., Gupta, R., Gupta, R., Khanna-Gupta, A., Sidransky, D. & 2 others, Chatterjee, A. & Gowda, H., Dec 1 2019, In : Scientific reports. 9, 1, 18793.

Research output: Contribution to journalArticle

Open Access
Proteomics
Epidermal Growth Factor Receptor
Therapeutics
Exome
Gene Amplification

Multiomic analysis of oral keratinocytes chronically exposed to shisha

Patil, S., Patel, K., Advani, J., Subbannayya, T., Rajagopalan, P., Babu, N., Solanki, H., Bhandi, S., Sidransky, D., Chatterjee, A., Gowda, H. & Ferrari, M., Jan 1 2019, In : Journal of Oral Pathology and Medicine.

Research output: Contribution to journalArticle

Exome
Keratinocytes
RNA
Mouth Neoplasms
Genes

PIM1 kinase promotes gallbladder cancer cell proliferation via inhibition of proline-rich Akt substrate of 40 kDa (PRAS40)

Subbannayya, T., Leal-Rojas, P., Zhavoronkov, A., Ozerov, I. V., Korzinkin, M., Babu, N., Radhakrishnan, A., Chavan, S., Raja, R., Pinto, S. M., Patil, A. H., Barbhuiya, M. A., Kumar, P., Guerrero-Preston, R., Navani, S., Tiwari, P. K., Kumar, R. V., Prasad, T. S. K., Roa, J. C., Pandey, A. & 4 others, Sidransky, D., Gowda, H., Izumchenko, E. & Chatterjee, A., Jan 1 2019, (Accepted/In press) In : Journal of Cell Communication and Signaling.

Research output: Contribution to journalArticle

Gallbladder Neoplasms
Cell proliferation
Proline
Phosphotransferases
Cell Proliferation

Proteomic Changes in Oral Keratinocytes Chronically Exposed to Shisha (Water Pipe)

Patil, S., Subbannayya, T., Mohan, S. V., Babu, N., Advani, J., Sathe, G., Rajagopalan, P., Patel, K., Bhandi, S., Solanki, H., Sidransky, D., Gowda, H., Chatterjee, A. & Ferrari, M., Feb 1 2019, In : OMICS A Journal of Integrative Biology. 23, 2, p. 86-97 12 p.

Research output: Contribution to journalArticle

Keratinocytes
Proteomics
Pipe
Water
Public health

Secretome analysis of oral keratinocytes chronically exposed to shisha

Patil, S., Babu, N., Subbannayya, T., Mohan, S. V., Sathe, G., Solanki, H. S., Rajagopalan, P., Patel, K., Advani, J., Bhandi, S., Sidransky, D., Chatterjee, A., Gowda, H. & Ferrari, M., Jan 1 2019, In : Cancer Biomarkers. 25, 1, p. 29-41 13 p.

Research output: Contribution to journalArticle

Keratinocytes
Proteomics
Proteins
Smoking
Computational Biology
2018

Bifunctional immune checkpoint-targeted antibody-ligand traps that simultaneously disable TGFβ enhance the efficacy of cancer immunotherapy

Ravi, R., Noonan, K., Pham, V., Bedi, R., Zhavoronkov, A., Ozerov, I. V., Makarev, E., Artemov, A. V., Wysocki, P. T., Mehra, R., Nimmagadda, S., Marchionni, L., Sidransky, D., Borrello, I. M., Izumchenko, E. & Bedi, A., Dec 1 2018, In : Nature Communications. 9, 1, 741.

Research output: Contribution to journalArticle

Transforming Growth Factors
CTLA-4 Antigen
antibodies
Immunotherapy
cancer

Cigarette smoke and chewing tobacco alter expression of different sets of miRNAs in oral keratinocytes

Bhat, M. Y., Advani, J., Rajagopalan, P., Patel, K., Nanjappa, V., Solanki, H. S., Patil, A. H., Bhat, F. A., Mathur, P. P., Nair, B., Prasad, T. S. K., Califano, J. A., Sidransky, D., Gowda, H. & Chatterjee, A., Dec 1 2018, In : Scientific Reports. 8, 1, 7040.

Research output: Contribution to journalArticle

Smokeless Tobacco
MicroRNAs
Keratinocytes
Smoke
Tobacco Products

First Person: David Sidransky, MD: Clinician-Scientist Transforms Cancer Early Detection

Sidransky, D., Aug 1 2018, In : Cancer. 124, 15, p. 3077-3078 2 p.

Research output: Contribution to journalArticle

Early Detection of Cancer

Functional characterization of alternatively spliced GSN in head and neck squamous cell carcinoma

Kelley, D. Z., Flam, E. L., Guo, T., Danilova, L. V., Zamuner, F. T., Bohrson, C., Considine, M., Windsor, E. J., Bishop, J. A., Zhang, C., Koch, W. M., Sidransky, D., Westra, W. H., Chung, C. H., Califano, J. A., Wheelan, S., Favorov, A., Florea, L. D., Fertig, E. & Gaykalova, D., Jan 1 2018, (Accepted/In press) In : Translational Research.

Research output: Contribution to journalArticle

Alternative Splicing
Protein Isoforms
Tumors
Neoplasms
Cell proliferation

Growth of malignant non-CNS tumors alters brain metabolome

Kovalchuk, A., Nersisyan, L., Mandal, R., Wishart, D., Mancini, M., Sidransky, D., Kolb, B. & Kovalchuk, O., Feb 20 2018, In : Frontiers in Genetics. 9, FEB, 41.

Research output: Contribution to journalArticle

Metabolome
Brain Neoplasms
Growth
Brain
Neoplasms
Progesterone
Oxidative Stress
Transcription Factors
Down-Regulation
Breast Neoplasms

Identification of potential biomarkers of head and neck squamous cell carcinoma using iTRAQ based quantitative proteomic approach

Babu, N., Mohan, S., Nanjappa, V., Chavan, S., Advani, J., Khan, A. A., Renuse, S., Radhakrishnan, A., Prasad, T. S. K., Kumar, R. V., Ray, J. G., Biswas, M., Thiyagarajan, S., Califano, J. A., Sidransky, D., Gowda, H. & Chatterjee, A., Aug 1 2018, In : Data in Brief. 19, p. 1124-1130 7 p.

Research output: Contribution to journalArticle

Proteomics
Biomarkers
Cell Line
Proteins
Carcinoma, squamous cell of head and neck

INSIG2 rs7566605 single nucleotide variant and global DNA methylation index levels are associated with weight loss in a personalized weight reduction program

Pirini, F., Rodriguez-Torres, S., Ayandibu, B. G., Orera-Clemente, M., Gonzalez-De La Vega, A., Lawson, F., Thorpe, R. J., Sidransky, D. & Guerrero-Preston, R., Jan 1 2018, In : Molecular Medicine Reports. 17, 1, p. 1699-1709 11 p.

Research output: Contribution to journalArticle

Weight Reduction Programs
DNA Methylation
Weight Loss
Nucleotides
Lipid Metabolism

miRNA and Proteomic Dysregulation in Non-Small Cell Lung Cancer in Response to Cigarette Smoke

Babu, N., Advani, J., Solanki, H. S., Patel, K., Jain, A., Khan, A. A., Radhakrishnan, A., Sahasrabuddhe, N. A., Mathur, P. P., Nair, B., Keshava Prasad, T. S., Chang, X., Sidransky, D., Gowda, H. & Chatterjee, A., Jan 1 2018, In : MicroRNA (Shariqah, United Arab Emirates). 7, 1, p. 38-53 16 p.

Research output: Contribution to journalArticle

MicroRNAs
Non-Small Cell Lung Carcinoma
Smoke
Tobacco Products
Proteomics

Molecular alterations associated with chronic exposure to cigarette smoke and chewing tobacco in normal oral keratinocytes

Rajagopalan, P., Patel, K., Jain, A. P., Nanjappa, V., Datta, K. K., Subbannayya, T., Mangalaparthi, K. K., Kumari, A., Manoharan, M., Coral, K., Murugan, S., Nair, B., Prasad, T. S. K., Mathur, P. P., Gupta, R., Gupta, R., Khanna-Gupta, A., Califano, J., Sidransky, D., Gowda, H. & 1 others, Chatterjee, A., May 28 2018, (Accepted/In press) In : Cancer Biology and Therapy. p. 1-13 13 p.

Research output: Contribution to journalArticle

Smokeless Tobacco
Keratinocytes
Smoke
Tobacco Products
Exome

Role of protein kinase N2 (PKN2) in cigarette smoke-mediated oncogenic transformation of oral cells

Rajagopalan, P., Nanjappa, V., Patel, K., Jain, A. P., Mangalaparthi, K. K., Patil, A. H., Nair, B., Mathur, P. P., Keshava Prasad, T. S., Califano, J. A., Sidransky, D., Gowda, H. & Chatterjee, A., Feb 26 2018, (Accepted/In press) In : Journal of Cell Communication and Signaling. p. 1-13 13 p.

Research output: Contribution to journalArticle

Smoke
Tobacco Products
Cells
Head and Neck Neoplasms
Keratinocytes

YAP1 and COX2 coordinately regulate urothelial cancer stem-like cells

Ooki, A., Del Carmen Rodriguez Pena, M., Marchionni, L., Dinalankara, W., Begum, A., Hahn, N., VandenBussche, C., Rasheed, Z. A., Mao, S., Netto, G. J., Sidransky, D. & Hoque, M., Jan 1 2018, In : Cancer Research. 78, 1, p. 168-181 14 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Urinary Bladder
Carcinoma
Dinoprostone
Drug Therapy
2017

Advancing toward a molecular characterization of polymorphous low grade adenocarcinoma

Wysocki, P. T., Westra, W. H., Sidransky, D. & Brait Rodrigues De Oliveira, M., 2017, (Accepted/In press) In : Oral Oncology.

Research output: Contribution to journalArticle

A panel of novel detection and prognostic methylated DNA markers in primary non–small cell lung cancer and serum DNA

Ooki, A., Maleki, Z., Tsay, J. C. J., Goparaju, C., Brait Rodrigues De Oliveira, M., Turaga, N., Nam, H. S., Rom, W. N., Pass, H. I., Sidransky, D., Guerrero-Preston, R. & Hoque, M., Nov 15 2017, In : Clinical Cancer Research. 23, 22, p. 7141-7152 12 p.

Research output: Contribution to journalArticle

Genetic Markers
Non-Small Cell Lung Carcinoma
Methylation
DNA
Serum

Chemo brain or tumor brain - that is the question: The presence of extracranial tumors profoundly affects molecular processes in the prefrontal cortex of TumorGraft mice

Kovalchuk, A., Ilnytskyy, Y., Rodriguez-Juarez, R., Shpyleva, S., Melnyk, S., Pogribny, I., Katz, A., Sidransky, D., Kovalchuk, O. & Kolb, B., Jul 1 2017, In : Aging. 9, 7, p. 1660-1676 17 p.

Research output: Contribution to journalArticle

Prefrontal Cortex
Brain Neoplasms
Brain
DNA Methylation
Neoplasms

Chronic Cigarette Smoke Mediated Global Changes in Lung Mucoepidermoid Cells: A Phosphoproteomic Analysis

Solanki, H. S., Advani, J., Khan, A. A., Radhakrishnan, A., Sahasrabuddhe, N. A., Pinto, S. M., Chang, X., Prasad, T. S. K., Mathur, P. P., Sidransky, D., Gowda, H. & Chatterjee, A., Aug 1 2017, In : OMICS A Journal of Integrative Biology. 21, 8, p. 474-487 14 p.

Research output: Contribution to journalArticle

Smoke
Tobacco Products
Lung
Proteomics
Lung Neoplasms

Cigarette smoke induces mitochondrial metabolic reprogramming in lung cells

Solanki, H. S., Babu, N., Jain, A. P., Bhat, M. Y., Puttamallesh, V. N., Advani, J., Raja, R., Mangalaparthi, K. K., Kumar, M. M., Prasad, T. S. K., Mathur, P. P., Sidransky, D., Gowda, H. & Chatterjee, A., Jan 1 2017, (Accepted/In press) In : Mitochondrion.

Research output: Contribution to journalArticle

Smoke
Tobacco Products
Lung
Oxidative Phosphorylation
Enzymes

Comparative mutational landscape analysis of patient-derived tumour xenografts

Brait Rodrigues De Oliveira, M., Izumchenko, E., Tsukamoto Kagohara, L., Long, S., Wysocki, P. T., Faherty, B., Fertig, E., Khor, T. O., Bruckheimer, E., Baia, G., Ciznadija, D., Sloma, I., Ben-Zvi, I., Paz, K. & Sidransky, D., Feb 14 2017, In : British Journal of Cancer. 116, 4, p. 515-523 9 p.

Research output: Contribution to journalArticle

Heterografts
Mutation
Neoplasms
Polymerase Chain Reaction
Exome

Corrigendum: A dual specificity kinase, DYRK1A, as a potential therapeutic target for head and neck squamous cell carcinoma

Radhakrishnan, A., Nanjappa, V., Raja, R., Sathe, G., Puttamallesh, V. N., Jain, A. P., Pinto, S. M., Balaji, S. A., Chavan, S., Sahasrabuddhe, N. A., Mathur, P. P., Kumar, M. M., Prasad, T. S. K., Santosh, V., Sukumar, G., Califano, J. A., Rangarajan, A., Sidransky, D., Pandey, A., Gowda, H. & 1 others, Chatterjee, A., Jun 26 2017, In : Scientific Reports. 7, 1 p.

Research output: Contribution to journalComment/debate

Phosphotransferases
Therapeutics
corrigendum
Carcinoma, squamous cell of head and neck

Early detection of gastric cancer using global, genome-wide and IRF4, ELMO1, CLIP4 and MSC DNA methylation in endoscopic biopsies

Pirini, F., Noazin, S., Jahuira-Arias, M. H., Rodriguez-Torres, S., Friess, L., Michailidi, C., Cok, J., Combe, J., Vargas, G., Prado, W., Soudry, E., Pérez, J., Yudin, T., Mancinelli, A., Unger, H., Ili-Gangas, C., Brebi-Mieville, P., Berg, D. E., Hayashi, M., Sidransky, D. & 2 others, Gilman, R. H. & Guerrero-Preston, R., 2017, In : Oncotarget. 8, 24, p. 38501-38516 16 p.

Research output: Contribution to journalArticle

DNA Methylation
Early Detection of Cancer
Stomach Neoplasms
Genome
Biopsy

Establishment and characterization of a platinum- and paclitaxel-resistant high grade serous ovarian carcinoma cell line

Teng, P. N., Bateman, N. W., Wang, G., Litzi, T., Blanton, B. E., Hood, B. L., Conrads, K. A., Ao, W., Oliver, K. E., Darcy, K. M., McGuire, W. P., Paz, K., Sidransky, D., Hamilton, C. A., Maxwell, G. L. & Conrads, T. P., Mar 1 2017, (Accepted/In press) In : Human Cell. p. 1-11 11 p.

Research output: Contribution to journalArticle

Paclitaxel
Platinum
Ovarian Neoplasms
Carcinoma
Cell Line

Expression of GULP1 in bronchial epithelium is associated with the progression of emphysema in chronic obstructive pulmonary disease

Datta, S., Nam, H. S., Hayashi, M., Maldonado, L., Goldberg, R., Brait Rodrigues De Oliveira, M., Sidransky, D., Illei, P. B., Baras, A., Vij, N. & Hoque, M., Mar 1 2017, In : Respiratory Medicine. 124, p. 72-78 7 p.

Research output: Contribution to journalArticle

Emphysema
Chronic Obstructive Pulmonary Disease
Epithelium
Methylation
Non-Small Cell Lung Carcinoma

Growth of malignant extracranial tumors alters microRNAome in the prefrontal cortex of TumorGraft mice

Kovalchuk, A., Ilnytskyy, Y., Rodriguez-Juarez, R., Katz, A., Sidransky, D., Kolb, B. & Kovalchuk, O., Jan 1 2017, In : Oncotarget. 8, 51, p. 88276-88293 18 p.

Research output: Contribution to journalArticle

Prefrontal Cortex
MicroRNAs
Growth
Brain
Brain Neoplasms

High-resolution microbiome profiling uncovers Fusobacterium nucleatum, Lactobacillus gasseri/johnsonii, and Lactobacillus vaginalis associated to oral and oropharyngeal cancer in saliva from HPV positive and HPV negative patients treated with surgery and chemo-radiation

Guerrero-Preston, R., White, J. R., Godoy-Vitorino, F., Rodríguez-Hilario, A., Navarro, K., González, H., Michailidi, C., Jedlicka, A. E., Canapp, S., Bondy, J., Dziedzic, A., Lagos, B. M., Rivera-Alvarez, G., Ili-Gangas, C., Brebi-Mieville, P., Westra, W., Koch, W. M., Kang, H., Marchionni, L., Kim, Y. & 1 others, Sidransky, D., Jan 1 2017, In : Oncotarget. 8, 67, p. 110931-110948 18 p.

Research output: Contribution to journalArticle

Papillomaviridae
Fusobacterium nucleatum
Oropharyngeal Neoplasms
Mouth Neoplasms
Microbiota

In silico analysis of pathways activation landscape in oral squamous cell carcinoma and oral leukoplakia

Makarev, E., Schubert, A. D., Kanherkar, R. R., London, N., Teka, M., Ozerov, I., Lezhnina, K., Bedi, A., Ravi, R., Mehra, R., Hoque, M. O., Sloma, I., Gaykalova, D. A., Csoka, A. B., Sidransky, D., Zhavoronkov, A. & Izumchenko, E., Dec 4 2017, In : Cell Death Discovery. 3, 1, 17022.

Research output: Contribution to journalArticle

Open Access
Oral Leukoplakia
Activation Analysis
Computer Simulation
Squamous Cell Carcinoma
Leukoplakia

Integrated analysis of whole-genome ChIP-Seq and RNA-Seq data of primary head and neck tumor samples associates HPV integration sites with open chromatin marks

Kelley, D. Z., Flam, E. L., Izumchenko, E., Danilova, L. V., Wulf, H. A., Guo, T., Singman, D. A., Afsari, B., Skaist, A. M., Considine, M., Welch, J. A., Stavrovskaya, E., Bishop, J. A., Westra, W. H., Khan, Z., Koch, W. M., Sidransky, D., Wheelan, S., Califano, J. A., Favorov, A. & 2 others, Fertig, E. & Gaykalova, D., Dec 1 2017, In : Cancer Research. 77, 23, p. 6538-6550 13 p.

Research output: Contribution to journalArticle

RNA Sequence Analysis
Chromatin Immunoprecipitation
Chromatin
Neck
Head

Long-Term Cigarette Smoke Exposure and Changes in MiRNA Expression and Proteome in Non-Small-Cell Lung Cancer

Advani, J., Subbannayya, Y., Patel, K., Khan, A. A., Patil, A. H., Jain, A. P., Solanki, H. S., Radhakrishnan, A., Pinto, S. M., Sahasrabuddhe, N. A., Thomas, J. K., Mathur, P. P., Nair, B. G., Chang, X., Prasad, T. S. K., Sidransky, D., Gowda, H. & Chatterjee, A., Jul 1 2017, In : OMICS A Journal of Integrative Biology. 21, 7, p. 390-403 14 p.

Research output: Contribution to journalArticle

Proteome
Non-Small Cell Lung Carcinoma
Smoke
Tobacco Products
Cells
Malignant Pleural Effusion
Non-Small Cell Lung Carcinoma
Fluorescence In Situ Hybridization
Neoplasms

NSD1- A nd NSD2-damaging mutations define a subset of laryngeal tumors with favorable prognosis

Peri, S., Izumchenko, E., Schubert, A. D., Slifker, M. J., Ruth, K., Serebriiskii, I. G., Guo, T., Burtness, B. A., Mehra, R., Ross, E. A., Sidransky, D. & Golemis, E. A., Dec 1 2017, In : Nature Communications. 8, 1, 1772.

Research output: Contribution to journalArticle

prognosis
mutations
set theory
Laryngeal Neoplasms
Tumors

Patient-derived xenografts effectively capture responses to oncology therapy in a heterogeneous cohort of patients with solid tumors

Izumchenko, E., Paz, K., Ciznadija, D., Sloma, I., Katz, A., Vasquez-Dunddel, D., Ben-Zvi, I., Stebbing, J., McGuire, W., Harris, W., Maki, R., Gaya, A., Bedi, A., Zacharoulis, S., Ravi, R., Wexler, L. H., Hoque, M., Rodriguez-Galindo, C., Pass, H., Peled, N. & 4 others, Davies, A., Morris, R., Hidalgo, M. & Sidransky, D., 2017, In : Annals of Oncology. 28, 10, p. 2595-2605 11 p.

Research output: Contribution to journalArticle

Heterografts
Neoplasms
Therapeutics
Exome
Translational Medical Research

Prenatal exposure to tobacco smoke leads to increased mitochondrial DNA content in umbilical cord serum associated to reduced gestational age

Pirini, F., Goldman, L. R., Soudry, E., Halden, R. U., Witter, F. R., Sidransky, D. & Guerrero-Preston, R., Jan 2 2017, In : International Journal of Environmental Health Research. 27, 1, p. 52-67 16 p.

Research output: Contribution to journalArticle

Tobacco
Umbilical Cord
Cotinine
Mitochondrial DNA
Smoke

Prognostic biomarkers in patients with human immunodeficiency virus-positive disease with head and neck squamous cell carcinoma

on behalf of the Head and Neck Cancer SPORE HIV supplement consortium, Dec 1 2017, In : Head and Neck. 39, 12, p. 2433-2443 11 p.

Research output: Contribution to journalArticle

Virus Diseases
Head and Neck Neoplasms
Biomarkers
HIV
Tumor Biomarkers

Promoter methylation of MCAM, ERa and ERβ in serum of early stage prostate cancer patients

Brait Rodrigues De Oliveira, M., Banerjee, M., Maldonado, L., Ooki, A., Loyo, M., Guida, E., Izumchenko, E., Mangold, L., Humphreys, E., Rosenbaum, E., Partin, A. W., Sidransky, D. & Hoque, M., 2017, In : Oncotarget. 8, 9, p. 15431-15440 10 p.

Research output: Contribution to journalArticle

Methylation
Prostatic Neoplasms
Prostate-Specific Antigen
Serum
Sensitivity and Specificity

Ranpirnase eradicates human papillomavirus in cultured cells and heals anogenital warts in a Phase i study

Squiquera, L., Taxman, D. J., Brendle, S. A., Torres, R., Sulley, J., Hodge, T., Christensen, N. & Sidransky, D., 2017, In : Antiviral Therapy. 22, 3, p. 247-255 9 p.

Research output: Contribution to journalArticle

Warts
Cultured Cells
Antiviral Agents
Cottontail rabbit papillomavirus
Endoribonucleases

SMAD4 loss is associated with cetuximab resistance and induction of MAPK/JNK activation in head and neck cancer cells

Ozawa, H., Ranaweera, R. S., Izumchenko, E., Makarev, E., Zhavoronkov, A., Fertig, E., Howard, J. D., Markovic, A., Bedi, A., Ravi, R., Perez, J., Le, Q. T., Kong, C. S., Jordan, R. C., Wang, H., Kang, H., Quon, H., Sidransky, D. & Chung, C. H., Sep 1 2017, In : Clinical Cancer Research. 23, 17, p. 5162-5175 14 p.

Research output: Contribution to journalArticle

Head and Neck Neoplasms
Gene Knockdown Techniques
Phenotype
Cell Line
Cetuximab

The KRAS-Variant and Cetuximab Response in Head and Neck Squamous Cell Cancer: A Secondary Analysis of a Randomized Clinical Trial

Weidhaas, J. B., Harris, J., Schaue, D., Chen, A. M., Chin, R., Axelrod, R., El-Naggar, A. K., Singh, A. K., Galloway, T. J., Raben, D., Wang, D., Matthiesen, C., Avizonis, V. N., Manon, R. R., Yumen, O., Nguyen-Tan, P. F., Trotti, A., Skinner, H., Zhang, Q., Ferris, R. L. & 2 others, Sidransky, D. & Chung, C. H., Apr 1 2017, In : JAMA oncology. 3, 4, p. 483-491 9 p.

Research output: Contribution to journalArticle

Squamous Cell Neoplasms
Head and Neck Neoplasms
Randomized Controlled Trials
Head
Transforming Growth Factors
2016

16S rRNA amplicon sequencing identifies microbiota associated with oral cancer, Human Papilloma Virus infection and surgical treatment

Guerrero-Preston, R., Godoy-Vitorino, F., Jedlicka, A. E., Rodríguez-Hilario, A., González, H., Bondy, J., Lawson, F., Folawiyo, O., Michailidi, C., Dziedzic, A., Thangavel, R., Hadar, T., Noordhuis, M. G., Westra, W., Koch, W. M. & Sidransky, D., Aug 1 2016, In : Oncotarget. 7, 32, p. 51320-51334 15 p.

Research output: Contribution to journalArticle

Papillomaviridae
Mouth Neoplasms
Microbiota
Virus Diseases
Fusobacteria

Adenoid cystic carcinoma: Emerging role of translocations and gene fusions

Wysocki, P. T., Izumchenko, E., Meir, J., Ha, P. K., Sidransky, D. & Brait Rodrigues De Oliveira, M., 2016, In : Oncotarget. 7, 40, p. 66239-66254 16 p.

Research output: Contribution to journalArticle

Adenoid Cystic Carcinoma
Gene Fusion
Neoplasms
Genetic Translocation
Genomics

A dual specificity kinase, DYRK1A, as a potential therapeutic target for head and neck squamous cell carcinoma

Radhakrishnan, A., Nanjappa, V., Raja, R., Sathe, G., Puttamallesh, V. N., Jain, A. P., Pinto, S. M., Balaji, S. A., Chavan, S., Sahasrabuddhe, N. A., Mathur, P. P., Kumar, M. M., Prasad, T. S. K., Santosh, V., Sukumar, G., Califano, J. A., Rangarajan, A., Sidransky, D., Pandey, A., Gowda, H. & 1 others, Chatterjee, A., Oct 31 2016, In : Scientific Reports. 6, 36132.

Research output: Contribution to journalArticle

Phosphotransferases
Cell Line
Therapeutics
Neoplasms
Phosphorylation

Antiviral effect of ranpirnase against Ebola virus

Hodge, T., Draper, K., Brasel, T., Freiberg, A., Squiquera, L., Sidransky, D., Sulley, J. & Taxman, D. J., Aug 1 2016, In : Antiviral Research. 132, p. 210-218 9 p.

Research output: Contribution to journalArticle

Ebolavirus
Antiviral Agents
Ebola Hemorrhagic Fever
Spleen
Infection

Chronic exposure to cigarette smoke leads to activation of p21 (RAC1)-activated kinase 6 (PAK6) in non-small cell lung cancer cells

Raja, R., Sahasrabuddhe, N. A., Radhakrishnan, A., Syed, N., Solanki, H. S., Puttamallesh, V. N., Balaji, S. A., Nanjappa, V., Datta, K. K., Babu, N., Renuse, S., Patil, A. H., Izumchenko, E., Prasad, T. S. K., Chang, X., Rangarajan, A., Sidransky, D., Pandey, A., Gowda, H. & Chatterjee, A., 2016, In : Oncotarget. 7, 38, p. 61229-61245 17 p.

Research output: Contribution to journalArticle

p21-Activated Kinases
Non-Small Cell Lung Carcinoma
Smoke
Tobacco Products
Lung Neoplasms