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2020

Revisiting the tumorigenesis timeline with a data-driven generative model

Lahouel, K., Younes, L., Danilova, L., Giardiello, F. M., Hruban, R. H., Groopman, J., Kinzler, K. W., Vogelstein, B., Geman, D. & Tomasetti, C., Jan 14 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 2, p. 857-864 8 p.

Research output: Contribution to journalArticle

Open Access
Carcinogenesis
Neoplasms
Genes
Adenomatous Polyposis Coli
Conservation of Natural Resources
2019

A multimodality test to guide the management of patients with a pancreatic cyst

Springer, S., Masica, D. L., Molin, M. D., Douville, C., Thoburn, C. J., Afsari, B., Li, L., Cohen, J. D., Thompson, E., Allen, P. J., Klimstra, D. S., Schattner, M. A., Max Schmidt, C., Yip-Schneider, M., Simpson, R. E., Castillo, C. F. D., Mino-Kenudson, M., Brugge, W., Brand, R. E., Singhi, A. D. & 40 others, Scarpa, A., Lawlor, R., Salvia, R., Zamboni, G., Hong, S. M., Hwang, D. W., Jang, J. Y., Kwon, W., Swan, N., Geoghegan, J., Falconi, M., Crippa, S., Doglioni, C., Paulino, J., Schulick, R. D., Edil, B. H., Park, W., Yachida, S., Hijioka, S., Van Hooft, J., He, J., Weiss, M. J., Burkhart, R., Makary, M., Canto, M. I., Goggins, M. G., Ptak, J., Dobbyn, L., Schaefer, J., Sillman, N., Popoli, M., Klein, A. P., Tomasetti, C., Karchin, R., Papadopoulos, N., Kinzler, K. W., Vogelstein, B., Wolfgang, C. L., Hruban, R. H. & Lennon, A. M., Jul 17 2019, In : Science translational medicine. 11, 501, eaav4772.

Research output: Contribution to journalArticle

Pancreatic Cyst
Cysts
Cyst Fluid
Practice Management
Standard of Care

An analysis of genetic heterogeneity in untreated cancers

Reiter, J. G., Baretti, M., Gerold, J. M., Makohon-Moore, A. P., Daud, A., Iacobuzio-Donahue, C. A., Azad, N., Kinzler, K. W., Nowak, M. A. & Vogelstein, B., Jan 1 2019, (Accepted/In press) In : Nature Reviews Cancer.

Research output: Contribution to journalArticle

Genetic Heterogeneity
Mutation
Neoplasms
Neoplasm Metastasis
Genes

An engineered antibody fragment targeting mutant β-catenin via major histocompatibility complex I neoantigen presentation

Miller, M. S., Douglass, J., Hwang, M. S., Skora, A. D., Murphy, M., Papadopoulos, N., Kinzler, K. W., Vogelstein, B., Zhou, S. & Gabelli, S. B., Jan 1 2019, In : Journal of Biological Chemistry. 294, 50, p. 19322-19334 13 p.

Research output: Contribution to journalArticle

Open Access
Catenins
Immunoglobulin Fragments
Major Histocompatibility Complex
Clone Cells
Peptides
Abdomen
Cone-Beam Computed Tomography
Tomography
Learning
Pancreatic Diseases

Application of Deep Learning to Pancreatic Cancer Detection: Lessons Learned From Our Initial Experience

Chu, L. C. H., Park, S., Kawamoto, S., Wang, Y., Zhou, Y., Shen, W., Zhu, Z., Xia, Y., Xie, L., Liu, F., Yu, Q., Fouladi, D. F., Shayesteh, S., Zinreich, E. S., Graves, J. S., Horton, K. M., Yuille, A. L., Hruban, R. H., Kinzler, K. W., Vogelstein, B. & 1 others, Fishman, E. K., Jan 1 2019, In : Journal of the American College of Radiology.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Learning

Applications of liquid biopsies for cancer

Mattox, A. K., Bettegowda, C., Zhou, S., Papadopoulos, N., Kinzler, K. W. & Vogelstein, B., Aug 28 2019, In : Science translational medicine. 11, 507, aay1984.

Research output: Contribution to journalArticle

Open Access
Biopsy
Neoplasms

Cell division rates decrease with age, providing a potential explanation for the age-dependent deceleration in cancer incidence

Tomasetti, C., Poling, J., Roberts, N., London, N., Pittman, M. E., Haffner, M. C., Rizzo, A., Baras, A., Karim, B., Kim, A., Heaphy, C. M., Meeker, A. K., Hruban, R. H., Iacobuzio-Donahue, C. A. & Vogelstein, B., Oct 8 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 41, p. 20482-20488 7 p.

Research output: Contribution to journalArticle

Open Access
Deceleration
Cell Division
Incidence
Neoplasms
Stem Cells

Circulating Tumor DNA Analyses as Markers of Recurrence Risk and Benefit of Adjuvant Therapy for Stage III Colon Cancer

Tie, J., Cohen, J. D., Wang, Y., Christie, M., Simons, K., Lee, M., Wong, R., Kosmider, S., Ananda, S., McKendrick, J., Lee, B., Cho, J. H., Faragher, I., Jones, I. T., Ptak, J., Schaeffer, M. J., Silliman, N., Dobbyn, L., Li, L., Tomasetti, C. & 4 others, Papadopoulos, N., Kinzler, K. W., Vogelstein, B. & Gibbs, P., Jan 1 2019, (Accepted/In press) In : JAMA Oncology.

Research output: Contribution to journalArticle

Colonic Neoplasms
Recurrence
DNA
Neoplasms
Therapeutics

Circulating tumor DNA as a potential marker of adjuvant chemotherapy benefit following surgery for localized pancreatic cancer

Lee, B., Lipton, L., Cohen, J., Tie, J., Javed, A. A., Li, L., Goldstein, D., Burge, M., Cooray, P., Nagrial, A., Tebbutt, N. C., Thomson, B., Nikfarjam, M., Harris, M., Haydon, A., Lawrence, B., Tai, D. W. M., Simons, K., Lennon, A. M., Wolfgang, C. L. & 5 others, Tomasetti, C., Papadopoulos, N., Kinzler, K. W., Vogelstein, B. & Gibbs, P., Sep 1 2019, In : Annals of Oncology. 30, 9, p. 1472-1478 7 p.

Research output: Contribution to journalArticle

Adjuvant Chemotherapy
Pancreatic Neoplasms
DNA
Neoplasms
gemcitabine
Consultants
Oncogenes
T-Lymphocytes
Conflict of Interest
Organized Financing
Artificial Intelligence
Pancreatic Neoplasms
Early Detection of Cancer
Radiology
Pathology

Direct detection and quantification of neoantigens

Wang, Q., Douglass, J., Hwang, M. S., Hsiue, E. H. C., Mog, B. J., Zhang, M., Papadopoulos, N., Kinzler, K. W., Zhou, S. & Vogelstein, B., Jan 1 2019, In : Cancer Immunology Research. 7, 11, p. 1748-1754 7 p.

Research output: Contribution to journalArticle

Peptides
Cancer Vaccines
HLA Antigens
Allergy and Immunology
Immunoprecipitation

Incidence and distribution of UroSEEK gene panel in a multi-institutional cohort of bladder urothelial carcinoma

Eich, M. L., Rodriguez Pena, M. D. C., Springer, S. U., Taheri, D., Tregnago, A. C., Salles, D. C., Bezerra, S. M., Cunha, I. W., Fujita, K., Ertoy, D., Bivalacqua, T., Tomasetti, C., Papadopoulos, N., Kinzler, K. W., Vogelstein, B. & Netto, G. J., Jan 1 2019, In : Modern Pathology.

Research output: Contribution to journalArticle

Urinary Bladder Neoplasms
Urinary Bladder
Papillary Carcinoma
Carcinoma
Incidence

p53: a tumor suppressor hiding in plain sight

Baker, S. J. & Vogelstein, B., Jul 19 2019, In : Journal of molecular cell biology. 11, 7, p. 536-538 3 p.

Research output: Contribution to journalArticle

Open Access
Neoplasms

Performance of novel non-invasive urine assay UroSEEK in cohorts of equivocal urine cytology

Rodriguez Pena, M. D. C., Springer, S. U., Taheri, D., Li, L., Tregnago, A. C., Eich, M. L., Eltoum, I. E. A., VandenBussche, C., Papadopoulos, N., Kinzler, K. W., Vogelstein, B. & Netto, G. J., Jan 1 2019, (Accepted/In press) In : Virchows Archiv.

Research output: Contribution to journalArticle

Cell Biology
Urine
Hematuria
Urinary Bladder Neoplasms
Sensitivity and Specificity

Persistent mutant oncogene specific T cells in two patients benefitting from anti-PD-1

Smith, K. N., Llosa, N. J., Cottrell, T. R., Siegel, N., Fan, H., Suri, P., Chan, H. Y., Guo, H., Oke, T., Awan, A. H., Verde, F., Danilova, L., Anagnostou, V., Tam, A. J., Luber, B. S., Bartlett, B. R., Aulakh, L. K., Sidhom, J. W., Zhu, Q., Sears, C. L. & 21 others, Cope, L., Sharfman, W. H., Thompson, E. D., Riemer, J., Marrone, K. A., Naidoo, J., Velculescu, V. E., Forde, P. M., Vogelstein, B., Kinzler, K. W., Papadopoulos, N., Durham, J. N., Wang, H., Le, D. T., Justesen, S., Taube, J. M., Diaz, L. A., Brahmer, J. R., Pardoll, D. M., Anders, R. A. & Housseau, F., Feb 11 2019, In : Journal for immunotherapy of cancer. 7, 1, 40.

Research output: Contribution to journalArticle

Open Access
Oncogenes
T-Lymphocytes
Biomarkers
DNA Mismatch Repair
Neoplasms

Prognostic Potential of Circulating Tumor DNA Measurement in Postoperative Surveillance of Nonmetastatic Colorectal Cancer

Wang, Y., Li, L., Cohen, J. D., Kinde, I., Ptak, J., Popoli, M., Schaefer, J., Silliman, N., Dobbyn, L., Tie, J., Gibbs, P., Tomasetti, C., Kinzler, K. W., Papadopoulos, N., Vogelstein, B. & Olsson, L., Jan 1 2019, In : JAMA Oncology.

Research output: Contribution to journalArticle

Colorectal Neoplasms
DNA
Neoplasms
Recurrence
Triage

Targeted sequencing of plasmacytoid urothelial carcinoma reveals frequent TERT promoter mutations

Palsgrove, D. N., Taheri, D., Springer, S. U., Cowan, M., Guner, G., Mendoza Rodriguez, M. A., Rodriguez Pena, M. D. C., Wang, Y., Kinde, I., Ricardo, B. F. P., Cunha, I., Fujita, K., Ertoy, D., Kinzler, K. W., Bivalacqua, T., Papadopoulos, N., Vogelstein, B. & Netto, G. J., Mar 1 2019, In : Human Pathology. 85, p. 1-9 9 p.

Research output: Contribution to journalArticle

Telomerase
Carcinoma
Mutation
Urinary Bladder Neoplasms
Histology

The potential role of circulating tumor DNA (ctDNA) in the further investigation of colorectal cancer patients with nonspecific findings on standard investigations

Wong, R., Tie, J., Lee, M., Cohen, J., Wang, Y., Li, L., Ma, S., Christie, M., Kosmider, S., Tomasetti, C., Papadopoulos, N., Kinzler, K. W., Vogelstein, B. & Gibbs, P., Jan 1 2019, (Accepted/In press) In : International Journal of Cancer.

Research output: Contribution to journalArticle

Colorectal Neoplasms
DNA
Neoplasms
Recurrence
Positron-Emission Tomography
Adenocarcinoma
Pancreas
Tissue Donors
Kidney
Pancreatic Diseases
2018

Cancer prevention: Molecular and epidemiologic consensus: Research in many fields emphasizes the value of prevention

Song, M., Vogelstein, B., Giovannucci, E. L., Willett, W. C. & Tomasetti, C., Sep 28 2018, In : Science. 361, 6409, p. 1317-1318 2 p.

Research output: Contribution to journalReview article

disease control
field method
molecular analysis
research work
epidemiology

Detection and localization of surgically resectable cancers with a multi-analyte blood test

Cohen, J. D., Li, L., Wang, Y., Thoburn, C., Afsari, B., Danilova, L. V., Douville, C., Javed, A. A., Wong, F., Mattox, A., Hruban, R. H., Wolfgang, C., Goggins, M. S., Molin, M. D., Wang, T-L., Roden, R. S., Klein, A., Ptak, J., Dobbyn, L., Schaefer, J. & 22 others, Silliman, N., Popoli, M., Vogelstein, J. T., Browne, J. D., Schoen, R. E., Brand, R. E., Tie, J., Gibbs, P., Wong, H. L., Mansfield, A. S., Jen, J., Hanash, S. M., Falconi, M., Allen, P. J., Zhou, S., Bettegowda, C., Diaz, L. A., Tomasetti, C., Kinzler, K. W., Vogelstein, B., O'Broin-Lennon, A. M. & Papadopoulos, N., Feb 23 2018, In : Science. 359, 6378, p. 926-930 5 p.

Research output: Contribution to journalArticle

Hematologic Tests
Liver Neoplasms
Ovarian Neoplasms
Esophagus
Pancreas
Long Interspersed Nucleotide Elements
Aneuploidy
Neoplasms
Biopsy
Chromosomes

Disruption of a self-amplifying catecholamine loop reduces cytokine release syndrome

Staedtke, V., Bai, R., Kim, K., Darvas, M., Davila, M. L., Riggins, G. J., Rothman, P. B., Papadopoulos, N., Kinzler, K. W., Vogelstein, B. & Zhou, S., Dec 13 2018, In : Nature. 564, 7735, p. 273-277 5 p.

Research output: Contribution to journalLetter

Catecholamines
Cytokines
T-Lymphocytes
alpha-Methyltyrosine
Bacteria

Erratum: Correction: Non-invasive detection of urothelial cancer through the analysis of driver gene mutations and aneuploidy (eLife (2018) 7 PII: e43237)

Springer, S. U., Chen, C. H., Rodriguez Pena, M. D. C., Li, L., Douville, C., Wang, Y., Cohen, J. D., Taheri, D., Silliman, N., Schaefer, J., Ptak, J., Dobbyn, L., Papoli, M., Kinde, I., Afsari, B., Tregnago, A. C., Bezerra, S. M., VandenBussche, C., Fujita, K., Ertoy, D. & 20 others, Cunha, I. W., Yu, L., Bivalacqua, T. J., Grollman, A. P., Diaz, L. A., Karchin, R., Danilova, L., Huang, C. Y., Shun, C. T., Turesky, R. J., Yun, B. H., Rosenquist, T. A., Pu, Y. S., Hruban, R. H., Tomasetti, C., Papadopoulos, N., Kinzler, K. W., Vogelstein, B., Dickman, K. G. & Netto, G. J., Nov 12 2018, In : eLife. 7

Research output: Contribution to journalComment/debate

Aneuploidy
Chromosomes
Gene expression
Genes
Gene Expression

Evaluation of liquid from the papanicolaou test and other liquid biopsies for the detection of endometrial and ovarian cancers

Wang, Y., Li, L., Douville, C., Cohen, J. D., Yen, T. T., Kinde, I., Sundfelt, K., Kjær, S. K., Hruban, R. H., Shih, I. M., Wang, T-L., Kurman, R. J., Springer, S., Ptak, J., Popoli, M., Schaefer, J., Silliman, N., Dobbyn, L., Tanner, E. J., Angarita, A. & 17 others, Lycke, M., Jochumsen, K., Afsari, B., Danilova, L. V., Levine, D. A., Jardon, K., Zeng, X., Arseneau, J., Fu, L., Diaz, L. A., Karchin, R., Tomasetti, C., Kinzler, K. W., Vogelstein, B., Nickles Fader, A. N., Gilbert, L. & Papadopoulos, N., Aug 1 2018, In : Obstetrical and Gynecological Survey. 73, 8, p. 463-464 2 p.

Research output: Contribution to journalComment/debate

Papanicolaou Test
Endometrial Neoplasms
Ovarian Neoplasms
Biopsy

Evaluation of liquid from the Papanicolaou test and other liquid biopsies for the detection of endometrial and ovarian cancers

Wang, Y., Li, L., Douville, C., Cohen, J. D., Yen, T. T., Kinde, I., Sundfelt, K., Kjær, S. K., Hruban, R. H., Shih, I. M., Wang, T-L., Kurman, R. J., Springer, S., Ptak, J., Popoli, M., Schaefer, J., Silliman, N., Dobbyn, L., Tanner, E. J., Angarita, A. & 17 others, Lycke, M., Jochumsen, K., Afsari, B., Danilova, L. V., Levine, D. A., Jardon, K., Zeng, X., Arseneau, J., Fu, L., Diaz, L. A., Karchin, R., Tomasetti, C., Kinzler, K. W., Vogelstein, B., Nickles Fader, A. N., Gilbert, L. & Papadopoulos, N., Mar 21 2018, In : Science Translational Medicine. 10, 433, 8793.

Research output: Contribution to journalArticle

Papanicolaou Test
Endometrial Neoplasms
Ovarian Neoplasms
Biopsy
Confidence Intervals

Genomic analysis identifies frequent deletions of Dystrophin in olfactory neuroblastoma

Gallia, G. L., Zhang, M., Ning, Y., Haffner, M. C., Batista, D., Binder, Z. A., Bishop, J. A., Hann, C., Hruban, R. H., Ishii, M., Klein, A., Reh, D. D., Rooper, L., Salmasi, V., Tamargo, R. J., Wang, Q., Williamson, T., Zhao, T., Zou, Y., Meeker, A. K. & 5 others, Agrawal, N., Vogelstein, B., Kinzler, K. W., Papadopoulos, N. & Bettegowda, C., Dec 1 2018, In : Nature Communications. 9, 1, 5410.

Research output: Contribution to journalArticle

Olfactory Esthesioneuroblastoma
deletion
Dystrophin
Genes
genes

Minimal functional driver gene heterogeneity among untreated metastases

Reiter, J. G., Makohon-Moore, A. P., Gerold, J. M., Heyde, A., Attiyeh, M. A., Kohutek, Z. A., Tokheim, C. J., Brown, A., DeBlasio, R. M., Niyazov, J., Zucker, A., Karchin, R., Kinzler, K. W., Iacobuzio-Donahue, C. A., Vogelstein, B. & Nowak, M. A., Sep 7 2018, In : Science. 361, 6406, p. 1033-1037 5 p.

Research output: Contribution to journalArticle

Neoplasm Metastasis
Genes
Mutation
Neoplasms
Phylogeny

Non-invasive detection of urothelial cancer through the analysis of driver gene mutations and aneuploidy

Springer, S. U., Chen, C. H., Del Carmen Rodriguez Pena, M., Li, L., Douville, C., Wang, Y., Cohen, J. D., Taheri, D., Silliman, N., Schaefer, J., Ptak, J., Dobbyn, L., Papoli, M., Kinde, I., Afsari, B., Tregnago, A. C., Bezerra, S. M., VandenBussche, C., Fujita, K., Ertoy, D. & 20 others, Cunha, I. W., Yu, L., Bivalacqua, T., Grollman, A. P., Diaz, L. A., Karchin, R., Danilova, L. V., Huang, C. Y., Shun, C. T., Turesky, R. J., Yun, B. H., Rosenquist, T. A., Pu, Y. S., Hruban, R. H., Tomasetti, C., Papadopoulos, N., Kinzler, K. W., Vogelstein, B., Dickman, K. G. & Netto, G. J., Mar 20 2018, In : eLife. 7, e32143.

Research output: Contribution to journalArticle

Cytology
Aneuploidy
Urinary Bladder Neoplasms
Genes
Cell Biology

Precancerous neoplastic cells can move through the pancreatic ductal system

Makohon-Moore, A. P., Matsukuma, K., Zhang, M., Reiter, J. G., Gerold, J. M., Jiao, Y., Sikkema, L., Attiyeh, M. A., Yachida, S., Sandone, C., Hruban, R. H., Klimstra, D. S., Papadopoulos, N., Nowak, M. A., Kinzler, K. W., Vogelstein, B. & Iacobuzio-Donahue, C. A., Sep 13 2018, In : Nature. 561, 7722, p. 201-205 5 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Pancreas
Carcinoma
Mutation
Genes
2017

A novel approach for selecting combination clinical markers of pathology applied to a large retrospective cohort of surgically resected pancreatic cysts

Masica, D. L., Molin, M. D., Wolfgang, C., Tomita, T., Ostovaneh, M. R., Blackford, A., Moran, R. A., Law, J. K., Barkley, T., Goggins, M. S., Canto, M., Pittman, M., Eshleman, J., Ali, S. Z., Fishman, E. K., Kamel, I. R., Raman, S. P., Zaheer, A., Ahuja, N., Makary, M. A. & 16 others, Weiss, M. J., Hirose, K., Cameron, J. L., Rezaee, N., He, J., Ahn, Y. J., Wu, W., Wang, Y., Springer, S., Diaz, L. L., Papadopoulos, N., Hruban, R. H., Kinzler, K. W., Vogelstein, B., Karchin, R. & O'Broin-Lennon, A. M., 2017, In : Journal of the American Medical Informatics Association. 24, 1, p. 145-152 8 p.

Research output: Contribution to journalArticle

Pancreatic Cyst
Clinical Pathology
Biomarkers
Sensitivity and Specificity
Serous Cystadenoma
High-Throughput Nucleotide Sequencing
Mutation
DNA
Technology
Precision Medicine

Cancer-associated mutations in endometriosis without cancer

Anglesio, M. S., Papadopoulos, N., Ayhan, A., Nazeran, T. M., Noë, M., Horlings, H. M., Lum, A., Jones, S., Senz, J., Seckin, T., Ho, J., Wu, R. C., Lac, V., Ogawa, H., Tessier-Cloutier, B., Alhassan, R., Wang, A., Wang, Y., Cohen, J. D., Wong, F. & 20 others, Hasanovic, A., Orr, N., Zhang, M., Popoli, M., McMahon, K. W., Wood, L. D., Mattox, A., Allaire, C., Segars, J., Williams, C., Tomasetti, C., Boyd, N., Kinzler, K. W., Gilks, C. B., Diaz, L., Wang, T-L., Vogelstein, B., Yong, P. J., Huntsman, D. G. & Shih, I. M., May 11 2017, In : New England Journal of Medicine. 376, 19, p. 1835-1848 14 p.

Research output: Contribution to journalArticle

Endometriosis
Mutation
Neoplasms
Epithelium
Exome

Combined circulating tumor DNA and protein biomarker-based liquid biopsy for the earlier detection of pancreatic cancers

Cohen, J. D., Javed, A. A., Thoburn, C., Wong, F., Tie, J., Gibbs, P., Schmidt, C. M., Yip-Schneider, M. T., Allen, P. J., Schattner, M., Brand, R. E., Singhi, A. D., Petersen, G. M., Hong, S. M., Kim, S. C., Falconi, M., Doglioni, C., Weiss, M. J., Ahuja, N., He, J. & 20 others, Makary, M. A., Maitra, A., Hanash, S. M., Dal Molin, M., Wang, Y., Li, L., Ptak, J., Dobbyn, L., Schaefer, J., Silliman, N., Popoli, M., Goggins, M. S., Hruban, R. H., Wolfgang, C., Klein, A., Tomasetti, C., Papadopoulos, N., Kinzler, K. W., Vogelstein, B. & O'Broin-Lennon, A. M., Sep 19 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 38, p. 10202-10207 6 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Early Detection of Cancer
Biomarkers
Biopsy
DNA

Deep Learning in Radiology: Now the Real Work Begins

Lugo-Fagundo, C., Vogelstein, B., Yuille, A. & Fishman, E. K., Jan 1 2017, (Accepted/In press) In : Journal of the American College of Radiology.

Research output: Contribution to journalArticle

Radiology
Learning

Identification of allosteric binding sites for PI3Kα oncogenic mutant specific inhibitor design

Miller, M. S., Maheshwari, S., McRobb, F. M., Kinzler, K. W., Amzel, M. L., Vogelstein, B. & Gabelli, S. B., Feb 15 2017, In : Bioorganic and Medicinal Chemistry. 25, 4, p. 1481-1486 6 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
Allosteric Site
Binding Sites
X ray crystallography
X Ray Crystallography

Limited heterogeneity of known driver gene mutations among the metastases of individual patients with pancreatic cancer

Makohon-Moore, A. P., Zhang, M., Reiter, J. G., Bozic, I., Allen, B., Kundu, D., Chatterjee, K., Wong, F., Jiao, Y., Kohutek, Z. A., Hong, J., Attiyeh, M., Javier, B., Wood, L. D., Hruban, R. H., Nowak, M. A., Papadopoulos, N., Kinzler, K. W., Vogelstein, B. & Iacobuzio-Donahue, C. A., Jan 16 2017, (Accepted/In press) In : Nature Genetics.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Neoplasm Metastasis
Mutation
Genes
Genome

Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade

Le, D., Uram, J., Smith, K., Wang, H., Bartlett, B. R., Aulakh, L. K., Lu, S., Kemberling, H., Wilt, C., Luber, B. S., Wong, F., Azad, N., Rucki, A. A., Laheru, D., Donehower, R. C., Zaheer, A., Fisher, G. A., Crocenzi, T. S., Lee, J. J., Greten, T. F. & 26 others, Duffy, A. G., Ciombor, K. K., Eyring, A. D., Lam, B. H., Joe, A., Kang, S. P., Holdhoff, M., Danilova, L. V., Cope, L., Meyer, C., Zhou, S., Goldberg, R. M., Armstrong, D. K., Bever, K., Nickles Fader, A. N., Taube, J. M., Housseau, F., Spetzler, D., Xiao, N., Pardoll, A. M., Papadopoulos, N., Kinzler, K. W., Eshleman, J., Vogelstein, B., Anders, R. A. & Diaz, L. A., Jul 28 2017, In : Science. 357, 6349, p. 409-413 5 p.

Research output: Contribution to journalArticle

Neoplasms
DNA Mismatch Repair
Disease-Free Survival
Turcot syndrome
Colorectal Neoplasms
Stem cells
Cell Division
stem cells
cell division
Stem Cells

Reconstructing metastatic seeding patterns of human cancers

Reiter, J. G., Makohon-Moore, A. P., Gerold, J. M., Bozic, I., Chatterjee, K., Iacobuzio-Donahue, C. A., Vogelstein, B. & Nowak, M. A., Jan 31 2017, In : Nature Communications. 8, 14114.

Research output: Contribution to journalArticle

sequencing
Phylogeny
inoculation
tumors
cancer

Role of stem-cell divisions in cancer risk

Tomasetti, C., Durrett, R., Kimmel, M., Lambert, A., Parmigiani, G., Zauber, A. & Vogelstein, B., Aug 9 2017, In : Nature. 548, 7666, p. E13-E14

Research output: Contribution to journalComment/debate

Selected reaction monitoring approach for validating peptide biomarkers

Wang, Q., Zhang, M., Tomita, T., Vogelstein, J. T., Zhou, S., Papadopoulos, N., Kinzler, K. W. & Vogelstein, B., Dec 19 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 51, p. 13519-13524 6 p.

Research output: Contribution to journalArticle

Biomarkers
Peptides
Ovarian Neoplasms
Cyclophilin A
Tumor Biomarkers

Spectrum of genetic mutations in de novo PUNLMP of the urinary bladder

Rodriguez Pena, M. D. C., Tregnago, A. C., Eich, M. L., Springer, S., Wang, Y., Taheri, D., Ertoy, D., Fujita, K., Bezerra, S. M., Cunha, I. W., Raspollini, M. R., Yu, L., Bivalacqua, T., Papadopoulos, N., Kinzler, K. W., Vogelstein, B. & Netto, G. J., Jun 8 2017, (Accepted/In press) In : Virchows Archiv. p. 1-7 7 p.

Research output: Contribution to journalArticle

Urinary Bladder
Mutation
Neoplasms
Urinary Bladder Neoplasms
Genes

Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention

Tomasetti, C., Li, L. & Vogelstein, B., Mar 24 2017, In : Science. 355, 6331, p. 1330-1334 5 p.

Research output: Contribution to journalArticle

Cell Division
Stem Cells
Mutation
Neoplasms
DNA Replication
2016

Aristolochic acid in the etiology of renal cell carcinoma

Hoang, M. L., Chen, C. H., Chen, P. C., Roberts, N., Dickman, K. G., Yun, B. H., Turesky, R. J., Pu, Y. S., Vogelstein, B., Papadopoulos, N., Grollman, A. P., Kinzler, K. W. & Rosenquist, T. A., Dec 1 2016, In : Cancer Epidemiology Biomarkers and Prevention. 25, 12, p. 1600-1608 9 p.

Research output: Contribution to journalArticle

Renal Cell Carcinoma
Aristolochia
Exome
Taiwan
aristolochic acid I

CEST theranostics: Label-free MR imaging of anticancer drugs

Li, Y., Chen, H., Xu, J., Yadav, N. N., Chan, K. W. Y., Luo, L., Mcmahon, M. T., Vogelstein, B., Van Zijl, P. C., Zhou, S. & Liu, G., 2016, In : Oncotarget. 7, 6, p. 6369-6378 10 p.

Research output: Contribution to journalArticle

Pharmaceutical Preparations
gemcitabine
Folic Acid Antagonists
Neoplasms
Liposomes

Circulating tumor DNA analysis detects minimal residual disease and predicts recurrence in patients with stage II colon cancer

Tie, J., Wang, Y., Tomasetti, C., Li, L., Springer, S., Kinde, I., Silliman, N., Tacey, M., Wong, H. L., Christie, M., Kosmider, S., Skinner, I., Wong, R., Steel, M., Tran, B., Desai, J., Jones, I., Haydon, A., Hayes, T., Price, T. J. & 6 others, Strausberg, R. L., Diaz, L. A., Papadopoulos, N., Kinzler, K. W., Vogelstein, B. & Gibbs, P., Jul 6 2016, In : Science Translational Medicine. 8, 346, 346ra92.

Research output: Contribution to journalArticle

Residual Neoplasm
Colonic Neoplasms
Recurrence
DNA
Neoplasms

Correction: Whole-genome sequencing of salivary gland adenoid cystic carcinoma (Cancer Prevention Research (2016) 9 (265-274) DOI: 10.1158/1940-6207.CAPR-15-0316)

Rettig, E. M., Talbot, C. C., Sausen, M., Jones, S., Bishop, J. A., Wood, L. D., Tokheim, C., Niknafs, N., Karchin, R., Fertig, E., Wheelan, S., Marchionni, L., Considine, M., Ling, S., Fakhry, C., Papadopoulos, N., Kinzler, K. W., Vogelstein, B., Ha, P. K. & Agrawal, N., Apr 1 2016, In : Cancer Prevention Research. 11, 4, 1 p.

Research output: Contribution to journalComment/debate

Conflict of Interest
Adenoid Cystic Carcinoma
Salivary Glands
Genome
Disclosure